YRC Public Data Repository - Protein Structure Prediction

Protein:	TDCE_ECOLI
Organism:	Escherichia coli
Length:	764 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TDCE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|32033949 - gi\|32033949\|ref\|ZP_00134205.1\| COG1882: Pyruvate-formate lyase [Actinobacillus pleuropneumoniae sero... gi\|126097302, gi... - gi\|126208510\|ref\|YP_001053735.1\| formate acetyltransferase [Actinobacillus pleuropneumoniae L20], gi... gi\|190150361, gi... - gi\|190150361\|ref\|YP_001968886.1\| formate acetyltransferase [Actinobacillus pleuropneumoniae serovar ...	1182.0	[0..9]	[764..5]
gi\|194443827, gi... - gi\|194443827\|ref\|YP_002040171.1\| formate acetyltransferase [Salmonella enterica subsp. enterica sero... gi\|194410131, gi... - gi\|194451827\|ref\|YP_002044965.1\| formate acetyltransferase [Salmonella enterica subsp. enterica sero... gi\|194471684, gi... - gi\|194471684\|ref\|ZP_03077668.1\| formate acetyltransferase [Salmonella enterica subsp. enterica serov... gi\|197213430, gi... - gi\|197249727\|ref\|YP_002145890.1\| formate acetyltransferase [Salmonella enterica subsp. enterica sero... gi\|205339897, gi... - gi\|205339897\|gb\|EDZ26661.1\| formate acetyltransferase [Salmonella enterica subsp. enterica serovar H... gi\|168263538, gi... - gi\|205347666\|gb\|EDZ34297.1\| formate acetyltransferase [Salmonella enterica subsp. enterica serovar H... gi\|168466561, gi... - gi\|195630994\|gb\|EDX49580.1\| formate acetyltransferase [Salmonella enterica subsp. enterica serovar N... gi\|205340731, gi... - gi\|205340731\|gb\|EDZ27495.1\| formate acetyltransferase [Salmonella enterica subsp. enterica serovar W... gi\|161364157, gi... - gi\|161614793\|ref\|YP_001588758.1\| hypothetical protein SPAB_02545 [Salmonella enterica subsp. enteric... gi\|167550352, gi... - gi\|205324590\|gb\|EDZ12429.1\| formate acetyltransferase [Salmonella enterica subsp. enterica serovar S... gi\|205327469, gi... - gi\|205327469\|gb\|EDZ14233.1\| formate acetyltransferase [Salmonella enterica subsp. enterica serovar 4... gi\|168230868, gi... - gi\|205334836\|gb\|EDZ21600.1\| formate acetyltransferase [Salmonella enterica subsp. enterica serovar K... gi\|206708167, gi... - gi\|207856364\|ref\|YP_002243015.1\| formate acetyltransferase 1 [Salmonella enterica subsp. enterica se... gi\|213424590 - gi\|213424590\|ref\|ZP_03357373.1\| formate acetyltransferase 1 [Salmonella enterica subsp. enterica ser... gi\|213648475 - gi\|213648475\|ref\|ZP_03378528.1\| formate acetyltransferase 1 [Salmonella enterica subsp. enterica ser... gi\|214002575 - gi\|214002575\|ref\|ZP_03413310.1\| formate acetyltransferase 1 [Salmonella enterica subsp. enterica ser... gi\|197264023, gi... - gi\|197264023\|ref\|ZP_03164097.1\| formate acetyltransferase [Salmonella enterica subsp. enterica serov... gi\|197362900, gi... - gi\|197362900\|ref\|YP_002142537.1\| formate acetyltransferase 1 [Salmonella enterica subsp. enterica se... gi\|197936423, gi... - gi\|198241907\|ref\|YP_002214896.1\| formate acetyltransferase [Salmonella enterica subsp. enterica sero... gi\|199603024, gi... - gi\|200390579\|ref\|ZP_03217190.1\| formate acetyltransferase [Salmonella enterica subsp. enterica serov... gi\|56413977, gi\|... - gi\|56413977\|ref\|YP_151052.1\| formate acetyltransferase 1 [Salmonella enterica subsp. enterica serova... gi\|16764333, gi\|... - gi\|16764333\|ref\|NP_459948.1\| pyruvate formate lyase I [Salmonella typhimurium LT2], gi\|16419484\|gb\|A... gi\|238913254 - gi\|238913254\|ref\|ZP_04657091.1\| formate acetyltransferase 1 [Salmonella enterica subsp. enterica ser... gi\|29138014, gi\|... - gi\|29142384\|ref\|NP_805726.1\| formate acetyltransferase 1 [Salmonella enterica subsp. enterica serova... gi\|16502136, gi\|... - gi\|25285937\|pir\|\|AC0613 formate acetyltransferase 1 [imported] - Salmonella enterica subsp. enterica... lcl\|NC_016856.1_... - [gene=pflB] [protein=pyruvate formate lyase I] [protein_id=YP_005236689.1] [location=complement(1013... gi\|16759843 - gi\|16759843\|ref\|NP_455460.1\| formate acetyltransferase 1 [Salmonella enterica subsp. enterica serova...	1182.0	[0..9]	[764..5]
gi\|75229892, gi\|... - gi\|75229892\|ref\|ZP_00716415.1\| COG1882: Pyruvate-formate lyase [Escherichia coli B7A], gi\|191166987\|...	1181.0	[0..9]	[764..5]
gi\|183179510, gi... - gi\|183179510\|ref\|ZP_02957721.1\| formate acetyltransferase [Vibrio cholerae MZO-3], gi\|183012921\|gb\|E... gi\|227081995, gi... - gi\|227081995\|ref\|YP_002810546.1\| formate acetyltransferase [Vibrio cholerae M66-2], gi\|227009883\|gb\|... gi\|15641868, gi\|... - gi\|9656396\|gb\|AAF95014.1\| formate acetyltransferase [Vibrio cholerae O1 biovar El Tor str. N16961], ... gi\|11256611 - pir\|\|F82147 formate acetyltransferase VC1866 [imported] - Vibrio cholerae (strain N16961 serogroup O... gi\|153213084, gi... - gi\|153213084\|ref\|ZP_01948622.1\| formate acetyltransferase [Vibrio cholerae 1587], gi\|124116131\|gb\|EA... gi\|121727110, gi... - gi\|121727110\|ref\|ZP_01680284.1\| formate acetyltransferase [Vibrio cholerae V52], gi\|121630488\|gb\|EAX... gi\|254848953, gi... - gi\|254848953\|ref\|ZP_05238303.1\| formate acetyltransferase [Vibrio cholerae MO10], gi\|254844658\|gb\|EE... gi\|153222989, gi... - gi\|153222989\|ref\|ZP_01953579.1\| formate acetyltransferase [Vibrio cholerae MAK 757], gi\|124118490\|gb... gi\|153823093, gi... - gi\|153823093\|ref\|ZP_01975760.1\| formate acetyltransferase [Vibrio cholerae B33], gi\|126519384\|gb\|EAZ... gi\|153830543, gi... - gi\|153830543\|ref\|ZP_01983210.1\| formate acetyltransferase [Vibrio cholerae 623-39], gi\|148873973\|gb\|... gi\|153818862, gi... - gi\|153818862\|ref\|ZP_01971529.1\| formate acetyltransferase [Vibrio cholerae NCTC 8457], gi\|126510590\|... gi\|146315155, gi... - gi\|227118314\|ref\|YP_002820210.1\| formate acetyltransferase [Vibrio cholerae O395], gi\|227013764\|gb\|A...	1181.0	[0..10]	[764..32]
PFLB_ECOLI - (P09373) Formate acetyltransferase 1 (EC 2.3.1.54) (Pyruvate formate-lyase 1)	1180.0	[0..9]	[764..4]
gi\|62127130, gi\|... - gi\|62179497\|ref\|YP_215914.1\| pyruvate formate lyase I, induced anaerobically [Salmonella enterica su...	1180.0	[0..9]	[764..5]
PFLB_ECOLI - Formate acetyltransferase 1 (EC 2.3.1.54) (Pyruvate formate-lyase 1) - Escherichia coli EG10701 - formate C-acetyltransferase 1, anaerobic; pyruvate formate-lyase 1 / Formate C-acetyltransferase 1; ... gi\|218364577, gi... - gi\|218557808\|ref\|YP_002390721.1\| pyruvate formate lyase I [Escherichia coli S88], gi\|218364577\|emb\|C... gi\|218553489, gi... - gi\|218553489\|ref\|YP_002386402.1\| pyruvate formate lyase I [Escherichia coli IAI1], gi\|218360257\|emb\|... gi\|218426307, gi... - gi\|218688743\|ref\|YP_002396955.1\| pyruvate formate lyase I [Escherichia coli ED1a], gi\|218426307\|emb\|... gi\|75512059, gi\|... - gi\|75512059\|ref\|ZP_00734644.1\| COG1882: Pyruvate-formate lyase [Escherichia coli 53638], gi\|18849291... gi\|73854936, gi\|... - gi\|74311459\|ref\|YP_309878.1\| formate acetyltransferase 1 [Shigella sonnei Ss046], gi\|73854936\|gb\|AAZ... gi\|191172132, gi... - gi\|75240977\|ref\|ZP_00724866.1\| COG1882: Pyruvate-formate lyase [Escherichia coli F11], gi\|191172132\|... gi\|192927747, gi... - gi\|75257382\|ref\|ZP_00728898.1\| COG1882: Pyruvate-formate lyase [Escherichia coli E22], gi\|193064690\|... gi\|117623121, gi... - gi\|117623121\|ref\|YP_852034.1\| PflB [Escherichia coli APEC O1], gi\|115512245\|gb\|ABJ00320.1\| PflB [Esc... gi\|124531972, gi... - gi\|124531972\|ref\|ZP_01702031.1\| formate acetyltransferase [Escherichia coli B], gi\|124498234\|gb\|EAY4... gi\|157160425, gi... - gi\|75195091\|ref\|ZP_00705161.1\| COG1882: Pyruvate-formate lyase [Escherichia coli HS], gi\|157160425\|r... gi\|194413580, gi... - gi\|75210408\|ref\|ZP_00710564.1\| COG1882: Pyruvate-formate lyase [Escherichia coli B171], gi\|194428365... gi\|194438693, gi... - gi\|83585846\|ref\|ZP_00924486.1\| COG1882: Pyruvate-formate lyase [Escherichia coli 101-1], gi\|19443869... gi\|75189958, gi\|... - gi\|75189958\|ref\|ZP_00703225.1\| COG1882: Pyruvate-formate lyase [Escherichia coli E24377A], gi\|157157... gi\|89107753, gi\|... - gi\|89107753\|ref\|AP_001533.1\| pyruvate formate lyase I [Escherichia coli str. K-12 substr. W3110], gi... gi\|91071578, gi\|... - gi\|91210004\|ref\|YP_539990.1\| formate acetyltransferase 1 [Escherichia coli UTI89], gi\|91071578\|gb\|AB... EG10701 - formate C-acetyltransferase 1, anaerobic; pyruvate formate-lyase 1 / Formate C-acetyltransferase 1; ... gi\|110641100, gi... - gi\|110641100\|ref\|YP_668830.1\| formate acetyltransferase 1 [Escherichia coli 536], gi\|110342692\|gb\|AB... gi\|227838884, gi... - gi\|227884132\|ref\|ZP_04001937.1\| pyruvate formate lyase I [Escherichia coli 83972], gi\|227838884\|gb\|E... gi\|237707109, gi... - gi\|237707109\|ref\|ZP_04537590.1\| formate acetyltransferase 1 [Escherichia sp. 3_2_53FAA], gi\|22689831... gi\|238900161, gi... - gi\|238900161\|ref\|YP_002925957.1\| pyruvate formate lyase I [Escherichia coli BW2952], gi\|238863359\|gb... gi\|169888396, gi... - gi\|170080561\|ref\|YP_001729881.1\| pyruvate formate lyase I [Escherichia coli str. K-12 substr. DH10B]... gi\|242376718, gi... - gi\|251784445\|ref\|YP_002998749.1\| hypothetical protein B21_00914 [Escherichia coli BL21], gi\|24237671... gi\|169755623, gi... - gi\|170020695\|ref\|YP_001725649.1\| formate acetyltransferase [Escherichia coli ATCC 8739], gi\|16975562... gi\|253977132, gi... - gi\|254287825\|ref\|YP_003053573.1\| pyruvate formate lyase I [Escherichia coli BL21(DE3)], gi\|253977132... gi\|253972918, gi... - gi\|254161017\|ref\|YP_003044125.1\| pyruvate formate lyase I [Escherichia coli B str. REL606], gi\|25397...	1180.0	[0..9]	[764..5]
gi\|187430216, gi... - gi\|75178294\|ref\|ZP_00698348.1\| COG1882: Pyruvate-formate lyase [Shigella boydii BS512], gi\|187733224... gi\|81246052, gi\|... - gi\|82544641\|ref\|YP_408588.1\| formate acetyltransferase 1 [Shigella boydii Sb227], gi\|81246052\|gb\|ABB... gi\|215264100, gi... - gi\|215486028\|ref\|YP_002328459.1\| pyruvate formate lyase I [Escherichia coli O127:H6 str. E2348/69], ...	1179.0	[0..9]	[764..5]
gi\|91225252, gi\|... - gi\|91225252\|ref\|ZP_01260420.1\| formate acetyltransferase [Vibrio alginolyticus 12G01], gi\|91189891\|g...	1179.0	[0..10]	[764..3]
gi\|75856414, gi\|... - gi\|75856414\|ref\|ZP_00764043.1\| COG1882: Pyruvate-formate lyase [Vibrio sp. Ex25], gi\|254229006\|ref\|Z...	1179.0	[0..10]	[764..3]

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Predicted Domain #1

Region A:
Residues: [1-764]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVDIDTSDK LYADAWLGFK GTDWKNEINV RDFIQHNYTP YEGDESFLAE ATPATTELWE  60
   61 KVMEGIRIEN ATHAPVDFDT NIATTITAHD AGYINQPLEK IVGLQTDAPL KRALHPFGGI 120
  121 NMIKSSFHAY GREMDSEFEY LFTDLRKTHN QGVFDVYSPD MLRCRKSGVL TGLPDGYGRG 180
  181 RIIGDYRRVA LYGISYLVRE RELQFADLQS RLEKGEDLEA TIRLREELAE HRHALLQIQE 240
  241 MAAKYGFDIS RPAQNAQEAV QWLYFAYLAA VKSQNGGAMS LGRTASFLDI YIERDFKAGV 300
  301 LNEQQAQELI DHFIMKIRMV RFLRTPEFDS LFSGDPIWAT EVIGGMGLDG RTLVTKNSFR 360
  361 YLHTLHTMGP APEPNLTILW SEELPIAFKK YAAQVSIVTS SLQYENDDLM RTDFNSDDYA 420
  421 IACCVSPMVI GKQMQFFGAR ANLAKTLLYA INGGVDEKLK IQVGPKTAPL MDDVLDYDKV 480
  481 MDSLDHFMDW LAVQYISALN IIHYMHDKYS YEASLMALHD RDVYRTMACG IAGLSVATDS 540
  541 LSAIKYARVK PIRDENGLAV DFEIDGEYPQ YGNNDERVDS IACDLVERFM KKIKALPTYR 600
  601 NAVPTQSILT ITSNVVYGQK TGNTPDGRRA GTPFAPGANP MHGRDRKGAV ASLTSVAKLP 660
  661 FTYAKDGISY TFSIVPAALG KEDPVRKTNL VGLLDGYFHH EADVEGGQHL NVNVMNREML 720
  721 LDAIEHPEKY PNLTIRVSGY AVRFNALTRE QQQDVISRTF TQAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1h16A
Description:	Pyruvate formate-lyase, PFL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.95058695475279	bayes_pls_golite062009
oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	1.72563679072631	bayes_pls_golite062009
oxidoreductase activity, acting on CH or CH2 groups	1.43559439297918	bayes_pls_golite062009
oxidoreductase activity	1.42705638794743	bayes_pls_golite062009
ribonucleoside-diphosphate reductase activity	1.37298861502572	bayes_pls_golite062009
C-acyltransferase activity	0.0923196663496405	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: