YRC Public Data Repository - Protein Structure Prediction

Protein:	ROB_ECOLI
Organism:	Escherichia coli
Length:	289 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ROB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|88934446, gi\|... - gi\|88934446\|ref\|ZP_01140089.1\| Helix-turn-helix, AraC type [Geobacter uraniumreducens Rf4], gi\|88918...	242.0	[0..2]	[287..55]
gi\|95133377, gi\|... - gi\|95930542\|ref\|ZP_01313277.1\| transcriptional regulator, AraC family [Desulfuromonas acetoxidans DS...	236.0	[0..1]	[288..1]
gi\|56129373, gi\|... - gi\|56415116\|ref\|YP_152191.1\| AraC family transcription regulator [Salmonella enterica subsp. enteric... gi\|197364045, gi... - gi\|197364045\|ref\|YP_002143682.1\| possible AraC-family transcriptional regulator [Salmonella enterica...	234.0	[0..3]	[288..9]
gi\|62129322, gi\|... - gi\|62181689\|ref\|YP_218106.1\| AraC family regulatory protein [Salmonella enterica subsp. enterica ser... gi\|224584975, gi... - gi\|224584975\|ref\|YP_002638774.1\| possible AraC-family transcriptional regulator [Salmonella enterica... gi\|194446792, gi... - gi\|194446792\|ref\|YP_002042440.1\| transcription activator, effector binding [Salmonella enterica subs...	233.0	[0..3]	[288..9]
gi\|197244088, gi... - gi\|197265833\|ref\|ZP_03165907.1\| transcription activator, effector binding [Salmonella enterica subsp... gi\|205331279, gi... - gi\|205331279\|gb\|EDZ18043.1\| transcription activator, effector binding [Salmonella enterica subsp. en... gi\|16421731, gi\|... - gi\|16766475\|ref\|NP_462090.1\| putative regulatory protein [Salmonella typhimurium LT2], gi\|16421731\|g... lcl\|NC_016856.1_... - [gene=STM14_3847] [protein=putative regulatory protein] [protein_id=YP_005239346.1] [location=comple...	232.0	[0..3]	[288..9]
gi\|238718667, gi... - gi\|77961952\|ref\|ZP_00825780.1\| COG2207: AraC-type DNA-binding domain-containing proteins [Yersinia m...	231.0	[0..1]	[289..1]
gi\|25350135, gi\|... - gi\|25350135\|pir\|\|AG0888 probable AraC-family transcription regulator STY3352 [imported] - Salmonella... gi\|213424350 - gi\|213424350\|ref\|ZP_03357174.1\| AraC family transcription regulator [Salmonella enterica subsp. ente... gi\|213647441 - gi\|213647441\|ref\|ZP_03377494.1\| AraC family transcription regulator [Salmonella enterica subsp. ente... gi\|29143438, gi\|... - gi\|29143438\|ref\|NP_806780.1\| AraC family transcription regulator [Salmonella enterica subsp. enteric... gi\|213973981 - gi\|213973981\|ref\|ZP_03401240.1\| AraC family transcription regulator [Salmonella enterica subsp. ente... gi\|16761951 - gi\|16761951\|ref\|NP_457568.1\| AraC family transcription regulator [Salmonella enterica subsp. enteric... gi\|214001849 - gi\|214001849\|ref\|ZP_03412584.1\| AraC family transcription regulator [Salmonella enterica subsp. ente... gi\|213027199 - gi\|213027199\|ref\|ZP_03341646.1\| AraC family transcription regulator [Salmonella enterica subsp. ente... gi\|213417333 - gi\|213417333\|ref\|ZP_03350475.1\| AraC family transcription regulator [Salmonella enterica subsp. ente...	231.0	[0..3]	[288..9]
gi\|238716365, gi... - gi\|77959725\|ref\|ZP_00823742.1\| COG2207: AraC-type DNA-binding domain-containing proteins [Yersinia b...	230.0	[0..1]	[289..1]
gi\|77976169 - gi\|77976169\|ref\|ZP_00831702.1\| COG2207: AraC-type DNA-binding domain-containing proteins [Yersinia f...	229.0	[0..1]	[289..1]

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Predicted Domain #1

Region A:
Residues: [1-289]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQAGIIRDL LIWLEGHLDQ PLSLDNVAAK AGYSKWHLQR MFKDVTGHAI GAYIRARRLS  60
   61 KSAVALRLTA RPILDIALQY RFDSQQTFTR AFKKQFAQTP ALYRRSPEWS AFGIRPPLRL 120
  121 GEFTMPEHKF VTLEDTPLIG VTQSYSCSLE QISDFRHEMR YQFWHDFLGN APTIPPVLYG 180
  181 LNETRPSQDK DDEQEVFYTT ALAQDQADGY VLTGHPVMLQ GGEYVMFTYE GLGTGVQEFI 240
  241 LTVYGTCMPM LNLTRRKGQD IERYYPAEDA KAGDRPINLR CELLIPIRR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.69897
Match:	1d5yA
Description:	Rob transcription factor, N-terminal domain; Rob transcription factor, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.57523737355937	bayes_pls_golite062009
DNA binding	3.00143272905695	bayes_pls_golite062009
nucleic acid binding	2.89825020286436	bayes_pls_golite062009
transcription factor activity	2.53664874743748	bayes_pls_golite062009
binding	1.68817361068715	bayes_pls_golite062009
sequence-specific DNA binding	0.46503550280898	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.24108783215685	bayes_pls_golite062009
transcription repressor activity	0.20862059645422	bayes_pls_golite062009
protein binding	0.111941607625758	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: