YRC Public Data Repository - Protein Structure Prediction

Protein:	RIBB_ECOLI
Organism:	Escherichia coli
Length:	217 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RIBB_ECOLI.

Description	E-value	Query Range	Subject Range
RIBAB_AQUAE, RIB... - Riboflavin biosynthesis protein ribBA OS=Aquifex aeolicus GN=ribBA PE=3 SV=1, Riboflavin biosynthesi... RIBBA_AQUAE - Riboflavin biosynthesis protein RibBA OS=Aquifex aeolicus (strain VF5) GN=ribBA PE=3 SV=1	373.0	[0..13]	[216..9]
gi\|86607094, gi\|... - gi\|86607094\|ref\|YP_475857.1\| riboflavin biosynthesis protein RibA [Synechococcus sp. JA-3-3Ab], gi\|8... gi\|86607094 - gi\|86607094\|ref\|YP_475857.1\| riboflavin biosynthesis protein RibA [Cyanobacteria bacterium Yellowsto...	360.0	[0..1]	[216..21]
gi\|78043761, gi\|... - gi\|78043761\|ref\|YP_360305.1\| 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II [Ca...	358.0	[0..13]	[216..3]
gi\|242232022, gi... - gi\|242256429\|ref\|ZP_04801320.1\| 3,4-dihydroxy-2-butanone 4-phosphate synthase [Thermoanaerobacter sp... RIBBA_THEPX - Riboflavin biosynthesis protein RibBA OS=Thermoanaerobacter sp. (strain X514) GN=ribBA PE=3 SV=1	357.0	[0..12]	[216..1]
gi\|241884501, gi... - gi\|241903098\|ref\|ZP_04787826.1\| 3,4-dihydroxy-2-butanone 4-phosphate synthase [Thermoanaerobacter br... RIBBA_THEP3 - Riboflavin biosynthesis protein RibBA OS=Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39...	355.0	[0..12]	[216..1]
gi\|53735199, gi\|... - gi\|67922265\|ref\|ZP_00515778.1\| 3,4-Dihydroxy-2-butanone 4-phosphate synthase:GTP cyclohydrolase II [...	355.0	[0..12]	[216..10]
gi\|125972630, gi... - gi\|67874098\|ref\|ZP_00504003.1\| 3,4-Dihydroxy-2-butanone 4-phosphate synthase:GTP cyclohydrolase II [... gi\|196199353, gi... - gi\|196251390\|ref\|ZP_03150060.1\| 3,4-dihydroxy-2-butanone 4-phosphate synthase [Clostridium thermocel...	355.0	[0..13]	[216..3]
gi\|220931844, gi... - gi\|89210620\|ref\|ZP_01189007.1\| 3,4-Dihydroxy-2-butanone 4-phosphate synthase:GTP cyclohydrolase II [...	355.0	[0..14]	[216..2]
gi\|78712790, gi\|... - gi\|78779291\|ref\|YP_397403.1\| bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohyd...	355.0	[0..2]	[216..10]
gi\|134299937, gi... - gi\|88947134\|ref\|ZP_01150147.1\| 3,4-Dihydroxy-2-butanone 4-phosphate synthase:GTP cyclohydrolase II [...	353.0	[0..9]	[216..1]

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Predicted Domain #1

Region A:
Residues: [1-217]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQTLLSSFG TPFERVENAL AALREGRGVM VLDDEDRENE GDMIFPAETM TVEQMALTIR  60
   61 HGSGIVCLCI TEDRRKQLDL PMMVENNTSA YGTGFTVTIE AAEGVTTGVS AADRITTVRA 120
  121 AIADGAKPSD LNRPGHVFPL RAQAGGVLTR GGHTEATIDL MTLAGFKPAG VLCELTNDDG 180
  181 TMARAPECIE FANKHNMALV TIEDLVAYRQ AHERKAS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	92.69897
Match:	1iezA
Description:	3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3,4-dihydroxy-2-butanone-4-phosphate synthase activity	7.56167968780416	bayes_pls_golite062009
GTP cyclohydrolase activity	2.51581618679202	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.92717548101547	bayes_pls_golite062009
cyclohydrolase activity	1.48770406828775	bayes_pls_golite062009
binding	1.05088380360844	bayes_pls_golite062009
nucleic acid binding	0.637633326908211	bayes_pls_golite062009
catalytic activity	0.343636936190038	bayes_pls_golite062009
protein binding	0.291469273637145	bayes_pls_golite062009
DNA binding	0.21448652890147	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: