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View Structure Prediction Details

Protein: PROA_ECOLI
Organism: Escherichia coli
Length: 417 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PROA_ECOLI.

Description E-value Query
Range
Subject
Range
gi|52785994, gi|... - gi|52785994|ref|YP_091823.1| DhaS [Bacillus licheniformis ATCC 14580], gi|52348496|gb|AAU41130.1| Dh...
440.0 [0..2] [413..62]
gi|20372798 - gi|20372798|emb|CAD30313.1| aldehyde dehydrogenase [Geobacillus stearothermophilus]
435.0 [0..2] [410..59]
AL1A1_RABIT - Retinal dehydrogenase 1 OS=Oryctolagus cuniculus GN=ALDH1A1 PE=2 SV=1
435.0 [0..2] [414..55]
AL1A1_CHICK - Retinal dehydrogenase 1 OS=Gallus gallus GN=ALDH1A1 PE=2 SV=1
433.0 [0..2] [414..68]
AL1A1_SHEEP - Retinal dehydrogenase 1 OS=Ovis aries GN=ALDH1A1 PE=1 SV=2
433.0 [0..2] [414..60]
AL1A1_BOVIN - Retinal dehydrogenase 1 OS=Bos taurus GN=ALDH1A1 PE=2 SV=3
433.0 [0..2] [414..60]
gi|2183299 - gi|2183299|gb|AAC51652.1| aldehyde dehydrogenase 1 [Homo sapiens]
432.0 [0..2] [414..60]
gi|60653829, gi|... - gi|60653831|gb|AAX29608.1| aldehyde dehydrogenase 1 family member A1 [synthetic construct], gi|60653...
431.0 [0..2] [414..60]
gi|45523555, gi|... - gi|67925207|ref|ZP_00518574.1| Aldehyde dehydrogenase (NAD+) [Crocosphaera watsonii WH 8501], gi|678...
431.0 [0..2] [411..55]

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Predicted Domain #1
Region A:
Residues: [1-417]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEQMGIAAK QASYKLAQLS SREKNRVLEK IADELEAQSE IILNANAQDV ADARANGLSE  60
   61 AMLDRLALTP ARLKGIADDV RQVCNLADPV GQVIDGGVLD SGLRLERRRV PLGVIGVIYE 120
  121 ARPNVTVDVA SLCLKTGNAV ILRGGKETCR TNAATVAVIQ DALKSCGLPA GAVQAIDNPD 180
  181 RALVSEMLRM DKYIDMLIPR GGAGLHKLCR EQSTIPVITG GIGVCHIYVD ESVEIAEALK 240
  241 VIVNAKTQRP STCNTVETLL VNKNIADSFL PALSKQMAES GVTLHADAAA LAQLQAGPAK 300
  301 VVAVKAEEYD DEFLSLDLNV KIVSDLDDAI AHIREHGTQH SDAILTRDMR NAQRFVNEVD 360
  361 SSAVYVNAST RFTDGGQFGL GAEVAVSTQK LHARGPMGLE ALTTYKWIGI GDYTIRA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 108.0
Match: 1o20A
Description: Gamma-glutamyl phosphate reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
glutamate-5-semialdehyde dehydrogenase activity 3.27180265380824 bayes_pls_golite062009
catalytic activity 2.80804701752928 bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity 2.65686856100363 bayes_pls_golite062009
oxidoreductase activity 2.31275077585879 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 2.24875477727877 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2.22720948878196 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1.6559690223037 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors 1.40606039383065 bayes_pls_golite062009
binding 1.06673666884196 bayes_pls_golite062009
histidinol dehydrogenase activity 0.258030369394064 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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