YRC Public Data Repository - Protein Structure Prediction

Protein:	NARP_ECOLI
Organism:	Escherichia coli
Length:	215 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NARP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|4982229, gi\|1... - gi\|4982229\|gb\|AAD36722.1\|AE001807_13 response regulator DrrA [Thermotoga maritima MSB8], gi\|15644403... gi\|7444020 - pir\|\|D72228 response regulator DrrA - Thermotoga maritima (strain MSB8)	185.0	[0..2]	[214..7]
gi\|28210824, gi\|... - gi\|28210824\|ref\|NP_781768.1\| transcriptional regulatory protein [Clostridium tetani E88], gi\|2820326...	185.0	[0..4]	[215..1]
gi\|1575577 - gi\|1575577\|gb\|AAC44436.1\| DNA-binding response regulator [Thermotoga maritima]	183.0	[0..4]	[214..1]
gi\|83588943, gi\|... - gi\|83588943\|ref\|YP_428952.1\| two component transcriptional regulator [Moorella thermoacetica ATCC 39...	182.0	[0..7]	[214..5]
gi\|109646584, gi... - gi\|68207819\|ref\|ZP_00559966.1\| Response regulator receiver:Transcriptional regulatory protein, C ter... gi\|89333300, gi\|... - gi\|89893852\|ref\|YP_517339.1\| hypothetical protein DSY1106 [Desulfitobacterium hafniense Y51], gi\|893...	181.0	[0..5]	[215..4]
gi\|98660701 - gi\|98660701\|dbj\|GAA02123.1\| unnamed protein product [Pelotomaculum thermopropionicum SI]	181.0	[0..2]	[214..100]
gi\|172059033, gi... - gi\|68055311\|ref\|ZP_00539457.1\| Response regulator receiver:Transcriptional regulatory protein, C-ter...	181.0	[0..4]	[214..1]
gi\|25300922 - pir\|\|G97109 response regulator (CheY-like receiver domain and DNA-binding HTH domain) [imported] - C... gi\|15894977, gi\|... - gi\|15894977\|ref\|NP_348326.1\| response regulator [Clostridium acetobutylicum ATCC 824], gi\|15024664\|g...	181.0	[0..4]	[215..1]
gi\|114566483, gi... - gi\|114566483\|ref\|YP_753637.1\| response regulator receiver protein [Syntrophomonas wolfei subsp. wolf...	181.0	[0..4]	[215..1]
gi\|77996843, gi\|... - gi\|78044728\|ref\|YP_360866.1\| DNA-binding response regulator [Carboxydothermus hydrogenoformans Z-290...	180.0	[0..7]	[215..1]

Back

Predicted Domain #1

Region A:
Residues: [1-215]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEATPFQVM IVDDHPLMRR GVRQLLELDP GSEVVAEAGD GASAIDLANR LDIDVILLDL  60
   61 NMKGMSGLDT LNALRRDGVT AQIIILTVSD ASSDVFALID AGADGYLLKD SDPEVLLEAI 120
  121 RAGAKGSKVF SERVNQYLRE REMFGAEEDP FSVLTERELD VLHELAQGLS NKQIASVLNI 180
  181 SEQTVKVHIR NLLRKLNVRS RVAATILFLQ QRGAQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	26.154902
Match:	1a04A
Description:	Nitrate/nitrite response regulator (NarL); Nitrate/nitrite response regulator (NarL), receiver domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
two-component response regulator activity	7.02872640261738	bayes_pls_golite062009
transcription regulator activity	5.23016166796951	bayes_pls_golite062009
signal transducer activity	4.51666042720644	bayes_pls_golite062009
molecular transducer activity	4.51666042720644	bayes_pls_golite062009
DNA binding	2.75354350283069	bayes_pls_golite062009
nucleic acid binding	2.67056525675208	bayes_pls_golite062009
protein histidine kinase activity	2.35011582062573	bayes_pls_golite062009
two-component sensor activity	2.32303301074957	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.28838869071567	bayes_pls_golite062009
transcription factor activity	2.12579037300919	bayes_pls_golite062009
binding	1.22427537074115	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: