YRC Public Data Repository - Protein Structure Prediction

Protein:	NAGC_ECOLI
Organism:	Escherichia coli
Length:	406 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NAGC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|194434447, gi... - gi\|83569126\|ref\|ZP_00920586.1\| COG1940: Transcriptional regulator/sugar kinase [Shigella dysenteriae...	339.0	[0..1]	[406..1]
gi\|42080 - gi\|42080\|emb\|CAA32354.1\| unnamed protein product [Escherichia coli]	337.0	[0..1]	[406..1]
gi\|62126906, gi\|... - gi\|62179273\|ref\|YP_215690.1\| N-acetylglucosamine operon transcriptional repressor [Salmonella enteri...	337.0	[0..1]	[405..1]
gi\|161364465, gi... - gi\|161615101\|ref\|YP_001589066.1\| hypothetical protein SPAB_02861 [Salmonella enterica subsp. enteric... gi\|205321735, gi... - gi\|205321735\|gb\|EDZ09574.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica serov... gi\|238911625 - gi\|238911625\|ref\|ZP_04655462.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica s... gi\|198244422, gi... - gi\|198244422\|ref\|YP_002214664.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica ... gi\|56128455, gi\|... - gi\|56414198\|ref\|YP_151273.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica sero... gi\|200390058, gi... - gi\|200390058\|ref\|ZP_03216669.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica s... gi\|205351960, gi... - gi\|205351960\|ref\|YP_002225761.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica ... gi\|206707943, gi... - gi\|207856140\|ref\|YP_002242791.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica ... gi\|194735429, gi... - gi\|194735429\|ref\|YP_002113787.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica ... gi\|197249215, gi... - gi\|197249215\|ref\|YP_002145654.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica ... gi\|197264061, gi... - gi\|197264061\|ref\|ZP_03164135.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica s... gi\|197363121, gi... - gi\|197363121\|ref\|YP_002142758.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica ... gi\|168467770, gi... - gi\|195629190\|gb\|EDX48558.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica serov... gi\|194401647, gi... - gi\|194442984\|ref\|YP_002039919.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica ... gi\|194406333, gi... - gi\|194448029\|ref\|YP_002044711.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica ... gi\|194457350, gi... - gi\|194470986\|ref\|ZP_03076970.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica s... gi\|168230563, gi... - gi\|205334806\|gb\|EDZ21570.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica serov... gi\|168236666, gi... - gi\|197290266\|gb\|EDY29622.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica serov... gi\|205339720, gi... - gi\|205339720\|gb\|EDZ26484.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica serov... gi\|205347128, gi... - gi\|205347128\|gb\|EDZ33759.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica serov... gi\|214000738 - gi\|214000738\|ref\|ZP_03411473.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica s... gi\|224582509, gi... - gi\|224582509\|ref\|YP_002636307.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica ... gi\|213023882 - gi\|213023882\|ref\|ZP_03338329.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica s... gi\|213586521 - gi\|213586521\|ref\|ZP_03368347.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica s... gi\|213619319 - gi\|213619319\|ref\|ZP_03373145.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica s... gi\|213650382 - gi\|213650382\|ref\|ZP_03380435.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica s... gi\|16759626 - gi\|16759626\|ref\|NP_455243.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica sero... gi\|16501918, gi\|... - gi\|25324855\|pir\|\|AG0584 N-acetylglucosamine repressor [imported] - Salmonella enterica subsp. enteri... gi\|29142601, gi\|... - gi\|29142601\|ref\|NP_805943.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica sero...	336.0	[0..1]	[405..1]
lcl\|NC_016856.1_... - [gene=nagC] [protein=N-acetylglucosamine operon transcriptional repressor] [protein_id=YP_005236394.... gi\|205328896, gi... - gi\|205328896\|gb\|EDZ15660.1\| N-acetylglucosamine repressor [Salmonella enterica subsp. enterica serov... gi\|16764052, gi\|... - gi\|16764052\|ref\|NP_459667.1\| N-acetylglucosamine operon transcriptional repressor [Salmonella typhim...	335.0	[0..1]	[405..1]
gi\|77973053, gi\|... - gi\|77973053\|ref\|ZP_00828606.1\| COG1940: Transcriptional regulator/sugar kinase [Yersinia frederiksen...	334.0	[0..1]	[406..1]
gi\|77961552 - gi\|77961552\|ref\|ZP_00825387.1\| COG1940: Transcriptional regulator/sugar kinase [Yersinia mollaretii ...	332.0	[0..1]	[406..1]
gi\|77956829, gi\|... - gi\|77956829\|ref\|ZP_00820906.1\| COG1940: Transcriptional regulator/sugar kinase [Yersinia bercovieri ...	332.0	[0..1]	[406..1]
gi\|238725386, gi... - gi\|77979055\|ref\|ZP_00834477.1\| COG1940: Transcriptional regulator/sugar kinase [Yersinia intermedia ...	331.0	[0..1]	[406..1]
gi\|45440919, gi\|... - gi\|45440919\|ref\|NP_992458.1\| putative N-acetylglucosamine regulatory protein [Yersinia pestis biovar...	326.0	[0..1]	[405..14]

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Predicted Domain #1

Region A:
Residues: [1-406]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTPGGQAQIG NVDLVKQLNS AAVYRLIDQY GPISRIQIAE QSQLAPASVT KITRQLIERG  60
   61 LIKEVDQQAS TGGRRAISIV TETRNFHAIG VRLGRHDATI TLFDLSSKVL AEEHYPLPER 120
  121 TQQTLEHALL NAIAQFIDSY QRKLRELIAI SVILPGLVDP DSGKIHYMPH IQVENWGLVE 180
  181 ALEERFKVTC FVGHDIRSLA LAEHYFGASQ DCEDSILVRV HRGTGAGIIS NGRIFIGRNG 240
  241 NVGEIGHIQV EPLGERCHCG NFGCLETIAA NAAIEQRVLN LLKQGYQSRV PLDDCTIKTI 300
  301 CKAANKGDSL ASEVIEYVGR HLGKTIAIAI NLFNPQKIVI AGEITEADKV LLPAIESCIN 360
  361 TQALKAFRTN LPVVRSELDH RSAIGAFALV KRAMLNGILL QHLLEN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	85.045757
Match:	1z05A
Description:	Crystal structure of the ROK family transcriptional regulator, homolog of E.coli MLC protein.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbohydrate kinase activity	0.7849166795124	bayes_pls_golite062009
binding	0.778934303209369	bayes_pls_golite062009
catalytic activity	0.666924658593345	bayes_pls_golite062009
sequence-specific DNA binding	0.53285802828572	bayes_pls_golite062009
transcription regulator activity	0.527726744596866	bayes_pls_golite062009
transcription repressor activity	0.513853050429619	bayes_pls_golite062009
hexokinase activity	0.32024736915472	bayes_pls_golite062009
protein binding	0.238186535482463	bayes_pls_golite062009
nucleic acid binding	0.226676176856305	bayes_pls_golite062009
DNA binding	0.0378796029809374	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: