YRC Public Data Repository - Protein Structure Prediction

Protein:	MSRB_ECOLI
Organism:	Escherichia coli
Length:	137 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSRB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|115368847, gi... - gi\|115374180\|ref\|ZP_01461467.1\| peptide methionine sulfoxide reductase MsrB [Stigmatella aurantiaca ...	230.0	[0..4]	[127..67]
MSRB_THEEB - Peptide methionine sulfoxide reductase MsrB OS=Thermosynechococcus elongatus (strain BP-1) GN=msrB P... MSRB_SYNEL - Peptide methionine sulfoxide reductase msrB OS=Synechococcus elongatus GN=msrB PE=3 SV=1	227.0	[0..1]	[129..1]
gi\|116699061, gi... - gi\|71544925\|ref\|ZP_00665902.1\| Protein of unknown function DUF25 [Syntrophobacter fumaroxidans MPOB]...	224.0	[0..5]	[129..59]
MSRB2_RHIME - Peptide methionine sulfoxide reductase MsrB 2 OS=Rhizobium meliloti (strain 1021) GN=msrB2 PE=3 SV=1 MSRB2_RHIME, MSB... - Peptide methionine sulfoxide reductase msrB 2 OS=Rhizobium meliloti GN=msrB2 PE=3 SV=1, (Q92Y46) Pep...	223.0	[0..1]	[135..1]
gi\|86558601, gi\|... - gi\|86610059\|ref\|YP_478821.1\| methionine-R-sulfoxide reductase [Synechococcus sp. JA-2-3B'a(2-13)], g... gi\|86610059 - gi\|86610059\|ref\|YP_478821.1\| methionine-R-sulfoxide reductase [Cyanobacteria bacterium Yellowstone B...	223.0	[0..5]	[129..41]
gi\|87137021, gi\|... - gi\|87201340\|ref\|YP_498597.1\| protein-methionine-S-oxide reductase [Novosphingobium aromaticivorans D...	223.0	[0..1]	[130..1]
gi\|150032007, gi... - gi\|150377460\|ref\|YP_001314055.1\| methionine sulfoxide reductase B [Sinorhizobium medicae WSM419], gi...	222.0	[0..1]	[135..1]
gi\|113526304, gi... - gi\|113867528\|ref\|YP_726017.1\| methionine sulfoxide reductase B [Ralstonia eutropha H16], gi\|11352630...	222.0	[0..1]	[136..1]
gi\|108764748, gi... - gi\|68562385\|ref\|ZP_00601648.1\| Protein of unknown function DUF25 [Rubrobacter xylanophilus DSM 9941]...	221.0	[0..4]	[128..9]
gi\|36959065, gi\|... - gi\|36959065\|gb\|AAQ87490.1\| Transcriptional regulator [Rhizobium sp. NGR234], gi\|227818810\|ref\|YP_002...	221.0	[0..1]	[135..1]

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Predicted Domain #1

Region A:
Residues: [1-137]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANKPSAEEL KKNLSEMQFY VTQNHGTEPP FTGRLLHNKR DGVYHCLICD APLFHSQTKY  60
   61 DSGCGWPSFY EPVSEESIRY IKDLSHGMQR IEIRCGNCDA HLGHVFPDGP QPTGERYCVN 120
  121 SASLRFTDGE NGEEING

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.522879
Match:	1l1dA
Description:	C-terminal MsrB domain of peptide methionine sulfoxide reductase PilB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor	5.90194589149201	bayes_pls_golite062009
protein-methionine-R-oxide reductase activity	5.64196103816384	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	3.02342037380774	bayes_pls_golite062009
peptide-methionine-(S)-S-oxide reductase activity	1.80676476343543	bayes_pls_golite062009
binding	1.67290562818139	bayes_pls_golite062009
catalytic activity	0.566791077255496	bayes_pls_golite062009
nucleic acid binding	0.555078494441175	bayes_pls_golite062009
ion binding	0.415760364192452	bayes_pls_golite062009
cation binding	0.404651661251597	bayes_pls_golite062009
metal ion binding	0.404651661251597	bayes_pls_golite062009
DNA binding	0.215568693193579	bayes_pls_golite062009
transcription regulator activity	0.183261590647643	bayes_pls_golite062009
protein binding	0.0755837372617499	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: