YRC Public Data Repository - Protein Structure Prediction

Protein:	MLTB_ECOLI
Organism:	Escherichia coli
Length:	361 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MLTB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|1097665 - gi\|1097665\|prf\|\|2114299A lytic transglycosylase 35kD	379.0	[0..1]	[361..1]
gi\|62128967, gi\|... - gi\|62181334\|ref\|YP_217751.1\| murein hydrolase B [Salmonella enterica subsp. enterica serovar Cholera...	376.0	[0..1]	[361..17]
lcl\|NC_016856.1_... - [gene=mltB] [protein=murein hydrolase B] [protein_id=YP_005238930.1] [location=complement(2997210..2... gi\|29143091, gi\|... - gi\|29143091\|ref\|NP_806433.1\| membrane-bound lytic murein transglycosylase B; catalyzes the cleavage ... gi\|205327921, gi... - gi\|205327921\|gb\|EDZ14685.1\| lytic murein transglycosylase B [Salmonella enterica subsp. enterica ser... gi\|16761607 - gi\|16761607\|ref\|NP_457224.1\| murein hydrolase B [Salmonella enterica subsp. enterica serovar Typhi s... gi\|213051939 - gi\|213051939\|ref\|ZP_03344817.1\| murein hydrolase B [Salmonella enterica subsp. enterica serovar Typh... gi\|25357799, gi\|... - gi\|25357799\|pir\|\|AB0844 membrane-bound lytic transglycosylase B precursor (EC 3.2.1.-) [imported] - ... gi\|213648100 - gi\|213648100\|ref\|ZP_03378153.1\| murein hydrolase B [Salmonella enterica subsp. enterica serovar Typh... gi\|16766137, gi\|... - gi\|16766137\|ref\|NP_461752.1\| murein hydrolase B [Salmonella typhimurium LT2], gi\|16421376\|gb\|AAL2171... gi\|214000002 - gi\|214000002\|ref\|ZP_03410737.1\| murein hydrolase B [Salmonella enterica subsp. enterica serovar Typh...	374.0	[0..1]	[361..1]
gi\|56414783, gi\|... - gi\|56414783\|ref\|YP_151858.1\| murein hydrolase B [Salmonella enterica subsp. enterica serovar Paratyp... gi\|224469136, gi... - gi\|224584609\|ref\|YP_002638407.1\| membrane-bound lytic transglycosylase B precursor [Salmonella enter... gi\|197363711, gi... - gi\|197363711\|ref\|YP_002143348.1\| murein hydrolase B [Salmonella enterica subsp. enterica serovar Par...	374.0	[0..1]	[361..1]
gi\|91212060, gi\|... - gi\|91212060\|ref\|YP_542046.1\| murein hydrolase B [Escherichia coli UTI89], gi\|91073634\|gb\|ABE08515.1\|... gi\|237706679, gi... - gi\|237706679\|ref\|ZP_04537160.1\| membrane-bound lytic Murein transglycosylase B [Escherichia sp. 3_2_...	374.0	[0..1]	[361..36]
gi\|110616221, gi... - gi\|110806673\|ref\|YP_690193.1\| murein hydrolase B [Shigella flexneri 5 str. 8401], gi\|110616221\|gb\|AB...	373.0	[0..1]	[361..21]
gi\|26249096, gi\|... - gi\|26249096\|ref\|NP_755136.1\| murein hydrolase B [Escherichia coli CFT073], gi\|26109503\|gb\|AAN81706.1...	373.0	[0..1]	[361..36]
gi\|78686367, gi\|... - gi\|78686367\|ref\|ZP_00851135.1\| Lytic murein transglycosylase [Shewanella sp. ANA-3], gi\|78505836\|gb\|...	373.0	[0..1]	[358..1]
gi\|115514056, gi... - gi\|117624932\|ref\|YP_853920.1\| murein hydrolase B [Escherichia coli APEC O1], gi\|115514056\|gb\|ABJ0213... gi\|110642821, gi... - gi\|110642821\|ref\|YP_670551.1\| murein hydrolase B [Escherichia coli 536], gi\|110344413\|gb\|ABG70650.1\|...	373.0	[0..1]	[361..17]
gi\|56383717, gi\|... - gi\|56480166\|ref\|NP_708509.2\| murein hydrolase B [Shigella flexneri 2a str. 301], gi\|56383717\|gb\|AAN4... gi\|30064061, gi\|... - gi\|30064061\|ref\|NP_838232.1\| murein hydrolase B [Shigella flexneri 2a str. 2457T], gi\|30042317\|gb\|AA...	371.0	[0..1]	[361..1]

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Predicted Domain #1

Region A:
Residues: [1-361]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKRRYVTLL PLFVLLAACS SKPKPTETDT TTGTPSGGFL LEPQHNVMQM GGDFANNPNA  60
   61 QQFIDKMVNK HGFDRQQLQE ILSQAKRLDS VLRLMDNQAP TTSVKPPSGP NGAWLRYRKK 120
  121 FITPDNVQNG VVFWNQYEDA LNRAWQVYGV PPEIIVGIIG VETRWGRVMG KTRILDALAT 180
  181 LSFNYPRRAE YFSGELETFL LMARDEQDDP LNLKGSFAGA MGYGQFMPSS YKQYAVDFSG 240
  241 DGHINLWDPV DAIGSVANYF KAHGWVKGDQ VAVMANGQAP GLPNGFKTKY SISQLAAAGL 300
  301 TPQQPLGNHQ QASLLRLDVG TGYQYWYGLP NFYTITRYNH STHYAMAVWQ LGQAVALARV 360
  361 Q

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	94.69897
Match:	1d0kA
Description:	36 kDa soluble lytic transglycosylase, SLT35
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
penicillin binding	2.70802519764961	bayes_pls_golite062009
catalytic activity	1.95328415115451	bayes_pls_golite062009
lysozyme activity	1.83799209924951	bayes_pls_golite062009
drug binding	1.60556297504678	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	1.16054683174437	bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds	1.07226857049823	bayes_pls_golite062009
hydrolase activity	0.677491712259	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	0.45061419828567	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: