YRC Public Data Repository - Protein Structure Prediction

Protein:	MELR_ECOLI
Organism:	Escherichia coli
Length:	302 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MELR_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|74314603, gi\|... - gi\|74314603\|ref\|YP_313022.1\| DNA-binding transcriptional regulator MelR [Shigella sonnei Ss046], gi\|...	202.0	[0..1]	[302..1]
gi\|195935907 - gi\|195935907\|ref\|ZP_03081289.1\| DNA-binding transcriptional regulator MelR [Escherichia coli O157:H7... gi\|168798209, gi... - gi\|189379084\|gb\|EDU97500.1\| melibiose operon regulatory protein [Escherichia coli O157:H7 str. EC508... gi\|189374764, gi... - gi\|189374764\|gb\|EDU93180.1\| melibiose operon regulatory protein [Escherichia coli O157:H7 str. EC869... gi\|189001665, gi... - gi\|189001665\|gb\|EDU70651.1\| melibiose operon regulatory protein [Escherichia coli O157:H7 str. EC407... gi\|25300788, gi\|... - pir\|\|D91266 regulator of melibiose operon [imported] - Escherichia coli (strain O157:H7, substrain ... gi\|209400157, gi... - gi\|209400157\|ref\|YP_002273663.1\| melibiose operon regulatory protein [Escherichia coli O157:H7 str. ... gi\|15834354, gi\|... - gi\|15834354\|ref\|NP_313127.1\| regulator of melibiose operon [Escherichia coli O157:H7], gi\|13364577\|d... gi\|208740576, gi... - gi\|208820453\|ref\|ZP_03260773.1\| melibiose operon regulatory protein [Escherichia coli O157:H7 str. E... gi\|208814330, gi... - gi\|208814330\|ref\|ZP_03255659.1\| melibiose operon regulatory protein [Escherichia coli O157:H7 str. E... gi\|208727719, gi... - gi\|208807918\|ref\|ZP_03250255.1\| melibiose operon regulatory protein [Escherichia coli O157:H7 str. E... gi\|168748025, gi... - gi\|188017480\|gb\|EDU55602.1\| melibiose operon regulatory protein [Escherichia coli O157:H7 str. EC411... gi\|168774488, gi... - gi\|187769820\|gb\|EDU33664.1\| melibiose operon regulatory protein [Escherichia coli O157:H7 str. EC419... gi\|168766389, gi... - gi\|189364246\|gb\|EDU82665.1\| melibiose operon regulatory protein [Escherichia coli O157:H7 str. EC448... gi\|189368591, gi... - gi\|189368591\|gb\|EDU87007.1\| melibiose operon regulatory protein [Escherichia coli O157:H7 str. EC450... gi\|168755300, gi... - gi\|189357491\|gb\|EDU75910.1\| melibiose operon regulatory protein [Escherichia coli O157:H7 str. EC440... gi\|15834354, gi\|... - gi\|15834354\|ref\|NP_313127.1\| DNA-binding transcriptional regulator MelR [Escherichia coli O157:H7 st... gi\|217321203, gi... - gi\|217324982\|ref\|ZP_03441066.1\| melibiose operon regulatory protein [Escherichia coli O157:H7 str. T... gi\|254796140, gi... - gi\|254796140\|ref\|YP_003080977.1\| DNA-binding transcriptional dual regulator [Escherichia coli O157:H...	202.0	[0..1]	[302..1]
gi\|191173396, gi... - gi\|191173396\|ref\|ZP_03034925.1\| melibiose operon regulatory protein [Escherichia coli F11], gi\|19090... gi\|110644476, gi... - gi\|110644476\|ref\|YP_672206.1\| DNA-binding transcriptional regulator MelR [Escherichia coli 536], gi\|...	201.0	[0..1]	[302..1]
gi\|110617431, gi... - gi\|110807883\|ref\|YP_691403.1\| DNA-binding transcriptional regulator MelR [Shigella flexneri 5 str. 8... gi\|30064687, gi\|... - gi\|30064687\|ref\|NP_838858.1\| DNA-binding transcriptional regulator MelR [Shigella flexneri 2a str. 2... gi\|24054613, gi\|... - gi\|24115313\|ref\|NP_709823.1\| DNA-binding transcriptional regulator MelR [Shigella flexneri 2a str. 3...	201.0	[0..1]	[302..1]
gi\|226901618, gi... - gi\|237703706\|ref\|ZP_04534187.1\| DNA-binding transcriptional regulator MelR [Escherichia sp. 3_2_53FA... gi\|115515529, gi... - gi\|117626405\|ref\|YP_859728.1\| DNA-binding transcriptional regulator MelR [Escherichia coli APEC O1],... gi\|91213665, gi\|... - gi\|91213665\|ref\|YP_543651.1\| DNA-binding transcriptional regulator MelR [Escherichia coli UTI89], gi... gi\|218367976, gi... - gi\|218561207\|ref\|YP_002394120.1\| DNA-binding transcriptional regulator MelR [Escherichia coli S88], ... gi\|218692414, gi... - gi\|218692414\|ref\|YP_002400626.1\| DNA-binding transcriptional regulator MelR [Escherichia coli ED1a],...	201.0	[0..1]	[302..1]
gi\|81247864, gi\|... - gi\|82546453\|ref\|YP_410400.1\| DNA-binding transcriptional regulator MelR [Shigella boydii Sb227], gi\|... gi\|187430977, gi... - gi\|187733985\|ref\|YP_001882785.1\| melibiose operon regulatory protein [Shigella boydii CDC 3083-94], ...	200.0	[0..1]	[302..1]
gi\|25300789 - pir\|\|A86107 regulator of melibiose operon [imported] - Escherichia coli (strain O157:H7, substrain ... gi\|15804710, gi\|... - gi\|15804710\|ref\|NP_290751.1\| DNA-binding transcriptional regulator MelR [Escherichia coli O157:H7 ED...	199.0	[0..1]	[302..1]
gi\|62182746, gi\|... - gi\|62182746\|ref\|YP_219163.1\| DNA-binding transcriptional regulator MelR [Salmonella enterica subsp. ...	192.0	[0..4]	[302..60]
gi\|75188834 - gi\|75188834\|ref\|ZP_00702101.1\| COG2207: AraC-type DNA-binding domain-containing proteins [Escherichi... gi\|83587243 - gi\|83587243\|ref\|ZP_00925872.1\| COG2207: AraC-type DNA-binding domain-containing proteins [Escherichi... gi\|194432232, gi... - gi\|194432232\|ref\|ZP_03064520.1\| melibiose operon regulatory protein [Shigella dysenteriae 1012], gi\|... gi\|75514879 - gi\|75514879\|ref\|ZP_00737108.1\| COG2207: AraC-type DNA-binding domain-containing proteins [Escherichi... gi\|75238647 - gi\|75238647\|ref\|ZP_00722636.1\| COG2207: AraC-type DNA-binding domain-containing proteins [Escherichi... gi\|75231287 - gi\|75231287\|ref\|ZP_00717694.1\| COG2207: AraC-type DNA-binding domain-containing proteins [Escherichi... gi\|75197970 - gi\|75197970\|ref\|ZP_00708040.1\| COG2207: AraC-type DNA-binding domain-containing proteins [Escherichi...	192.0	[0..7]	[302..1]
gi\|75259037 - gi\|75259037\|ref\|ZP_00730405.1\| COG2207: AraC-type DNA-binding domain-containing proteins [Escherichi... gi\|75212047 - gi\|75212047\|ref\|ZP_00712102.1\| COG2207: AraC-type DNA-binding domain-containing proteins [Escherichi...	192.0	[0..7]	[302..1]

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Predicted Domain #1

Region A:
Residues: [1-180]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTDTFMCSS DEKQTRSPLS LYSEYQRMEI EFRAPHIMPT SHWHGQVEVN VPFDGDVEYL  60
   61 INNEKVNINQ GHITLFWACT PHQLTDTGTC QSMAIFNLPM HLFLSWPLDK DLINHVTHGM 120
  121 VIKSLATQQL SPFEVRRWQQ ELNSPNEQIR QLAIDEIGLM LKRFSLSGWE PILVNKTSRT 180
  181

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.30103
Match:	2arcA
Description:	Regulatory protein AraC
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [181-302]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKNSVSRHAQ FYVSQMLGFI AENYDQALTI NDVAEHVKLN ANYAMGIFQR VMQLTMKQYI  60
   61 TAMRINHVRA LLSDTDKSIL DIALTAGFRS SSRFYSTFGK YVGMSPQQYR KLSQQRRQTF 120
  121 PG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	21.154902
Match:	1d5yA
Description:	Rob transcription factor, N-terminal domain; Rob transcription factor, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.334577365229545	bayes_pls_golite062009
transcription regulator activity	0.0696342306231097	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: