YRC Public Data Repository - Protein Structure Prediction

Protein:	MANA_ECOLI
Organism:	Escherichia coli
Length:	391 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MANA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|218554180, gi... - gi\|218554180\|ref\|YP_002387093.1\| mannose-6-phosphate isomerase [Escherichia coli IAI1], gi\|218360948... gi\|218695175, gi... - gi\|218695175\|ref\|YP_002402842.1\| mannose-6-phosphate isomerase [Escherichia coli 55989], gi\|21835190... gi\|75257032, gi\|... - gi\|75257032\|ref\|ZP_00728592.1\| COG1482: Phosphomannose isomerase [Escherichia coli E22], gi\|19306489... gi\|190904055, gi... - gi\|75230938\|ref\|ZP_00717387.1\| COG1482: Phosphomannose isomerase [Escherichia coli B7A], gi\|19116592... gi\|75212950, gi\|... - gi\|75212950\|ref\|ZP_00712948.1\| COG1482: Phosphomannose isomerase [Escherichia coli B171], gi\|1944260...	464.0	[0..1]	[391..1]
gi\|74312062, gi\|... - gi\|74312062\|ref\|YP_310481.1\| mannose-6-phosphate isomerase [Shigella sonnei Ss046], gi\|73855539\|gb\|A... gi\|82544020, gi\|... - gi\|82544020\|ref\|YP_407967.1\| mannose-6-phosphate isomerase [Shigella boydii Sb227], gi\|81245431\|gb\|A... gi\|193070276, gi... - gi\|75234926\|ref\|ZP_00719205.1\| COG1482: Phosphomannose isomerase [Escherichia coli E110019], gi\|1930... gi\|75512954, gi\|... - gi\|75512954\|ref\|ZP_00735435.1\| COG1482: Phosphomannose isomerase [Escherichia coli 53638], gi\|188494... gi\|169754962, gi... - gi\|170020034\|ref\|YP_001724988.1\| mannose-6-phosphate isomerase, class I [Escherichia coli ATCC 8739]... gi\|124529232, gi... - gi\|124529232\|ref\|ZP_01700307.1\| mannose-6-phosphate isomerase, class I [Escherichia coli B], gi\|1245... gi\|75178492, gi\|... - gi\|75178492\|ref\|ZP_00698538.1\| COG1482: Phosphomannose isomerase [Shigella boydii BS512], gi\|1877332... gi\|75195693, gi\|... - gi\|75195693\|ref\|ZP_00705763.1\| COG1482: Phosphomannose isomerase [Escherichia coli HS], gi\|157161074...	463.0	[0..1]	[391..1]
gi\|209162153, gi... - gi\|209400753\|ref\|YP_002270685.1\| mannose-6-phosphate isomerase, class I [Escherichia coli O157:H7 st... gi\|208739558, gi... - gi\|208819435\|ref\|ZP_03259755.1\| mannose-6-phosphate isomerase, class I [Escherichia coli O157:H7 str... gi\|208731331, gi... - gi\|208816988\|ref\|ZP_03258108.1\| mannose-6-phosphate isomerase, class I [Escherichia coli O157:H7 str... gi\|208810689, gi... - gi\|208810689\|ref\|ZP_03252565.1\| mannose-6-phosphate isomerase, class I [Escherichia coli O157:H7 str... gi\|13361786, gi\|... - gi\|15831573\|ref\|NP_310346.1\| mannose-6-phosphate isomerase [Escherichia coli O157:H7 str. Sakai], gi... gi\|254592630, gi... - gi\|254793230\|ref\|YP_003078067.1\| mannose-6-phosphate isomerase [Escherichia coli O157:H7 str. TW1435... gi\|217318040, gi... - gi\|217328693\|ref\|ZP_03444774.1\| mannose-6-phosphate isomerase, class I [Escherichia coli O157:H7 str... gi\|168771153, gi... - gi\|189360028\|gb\|EDU78447.1\| mannose-6-phosphate isomerase, class I [Escherichia coli O157:H7 str. EC... gi\|168763685, gi... - gi\|189366165\|gb\|EDU84581.1\| mannose-6-phosphate isomerase, class I [Escherichia coli O157:H7 str. EC... gi\|189355538, gi... - gi\|189355538\|gb\|EDU73957.1\| mannose-6-phosphate isomerase, class I [Escherichia coli O157:H7 str. EC... gi\|168750575, gi... - gi\|188015227\|gb\|EDU53349.1\| mannose-6-phosphate isomerase, class I [Escherichia coli O157:H7 str. EC... gi\|168800871, gi... - gi\|189376916\|gb\|EDU95332.1\| mannose-6-phosphate isomerase, class I [Escherichia coli O157:H7 str. EC... gi\|168789448, gi... - gi\|189370950\|gb\|EDU89366.1\| mannose-6-phosphate isomerase, class I [Escherichia coli O157:H7 str. EC... gi\|13361786, gi\|... - gi\|15831573\|ref\|NP_310346.1\| mannose-6-phosphate isomerase [Escherichia coli O157:H7], gi\|13361786\|d... gi\|188999211, gi... - gi\|188999211\|gb\|EDU68197.1\| mannose-6-phosphate isomerase, class I [Escherichia coli O157:H7 str. EC... gi\|209769824, gi... - pir\|\|G90918 mannose-6-phosphate isomerase [imported] - Escherichia coli (strain O157:H7, substrain ... gi\|187768705, gi... - gi\|187768705\|gb\|EDU32549.1\| mannose-6-phosphate isomerase, class I [Escherichia coli O157:H7 str. EC... gi\|15802027, gi\|... - gi\|15802027\|ref\|NP_288048.1\| mannose-6-phosphate isomerase [Escherichia coli O157:H7 EDL933], gi\|125...	463.0	[0..1]	[391..1]
Q66AE5\|Q66AE5_YERPS - Mannose-6-phosphate isomerase - Yersinia pseudotuberculosis gi\|51589793, gi\|... - gi\|51596511\|ref\|YP_070702.1\| mannose-6-phosphate isomerase [Yersinia pseudotuberculosis IP 32953], g...	462.0	[0..1]	[391..1]
gi\|26108263, gi\|... - gi\|26247860\|ref\|NP_753900.1\| mannose-6-phosphate isomerase [Escherichia coli CFT073], gi\|26108263\|gb... gi\|227885972, gi... - gi\|227885972\|ref\|ZP_04003777.1\| mannose-6-phosphate isomerase [Escherichia coli 83972], gi\|227837064... gi\|75238826, gi\|... - gi\|75238826\|ref\|ZP_00722810.1\| COG1482: Phosphomannose isomerase [Escherichia coli F11], gi\|19117343... gi\|110641735, gi... - gi\|110641735\|ref\|YP_669465.1\| mannose-6-phosphate isomerase [Escherichia coli 536], gi\|110343327\|gb\|...	462.0	[0..1]	[391..1]
gi\|108775545, gi... - gi\|108811897\|ref\|YP_647664.1\| mannose-6-phosphate isomerase [Yersinia pestis Nepal516], gi\|108775545... gi\|108807618, gi... - gi\|108807618\|ref\|YP_651534.1\| mannose-6-phosphate isomerase [Yersinia pestis Antiqua], gi\|108779531\|... gi\|22125994, gi\|... - gi\|22125994\|ref\|NP_669417.1\| mannose-6-phosphate isomerase [Yersinia pestis KIM], gi\|21958940\|gb\|AAM... gi\|145598169, gi... - gi\|145598169\|ref\|YP_001162245.1\| mannose-6-phosphate isomerase [Yersinia pestis Pestoides F], gi\|145...	461.0	[0..1]	[391..33]
gi\|81241230, gi\|... - gi\|82777082\|ref\|YP_403431.1\| mannose-6-phosphate isomerase [Shigella dysenteriae Sd197], gi\|81241230...	461.0	[0..1]	[391..1]
gi\|117623799, gi... - gi\|117623799\|ref\|YP_852712.1\| mannose-6-phosphate isomerase [Escherichia coli APEC O1], gi\|115512923... gi\|91210824, gi\|... - gi\|91210824\|ref\|YP_540810.1\| mannose-6-phosphate isomerase [Escherichia coli UTI89], gi\|91072398\|gb\|... gi\|218558483, gi... - gi\|218558483\|ref\|YP_002391396.1\| mannose-6-phosphate isomerase [Escherichia coli S88], gi\|218365252\|...	461.0	[0..1]	[391..1]
gi\|167469694 - gi\|167469694\|ref\|ZP_02334398.1\| mannose-6-phosphate isomerase [Yersinia pestis FV-1] gi\|166208026, gi... - gi\|166210846\|ref\|ZP_02236881.1\| mannose-6-phosphate isomerase, class I [Yersinia pestis biovar Antiq... gi\|229898337, gi... - gi\|229898337\|ref\|ZP_04513484.1\| mannose-6-phosphate isomerase [Yersinia pestis biovar Orientalis str... gi\|167049676, gi... - gi\|167400823\|ref\|ZP_02306329.1\| mannose-6-phosphate isomerase, class I [Yersinia pestis biovar Antiq... gi\|229902197, gi... - gi\|229902197\|ref\|ZP_04517318.1\| mannose-6-phosphate isomerase [Yersinia pestis Nepal516], gi\|2296810... gi\|167419953, gi... - gi\|167419953\|ref\|ZP_02311706.1\| mannose-6-phosphate isomerase, class I [Yersinia pestis biovar Orien... gi\|229894949, gi... - gi\|229894949\|ref\|ZP_04510127.1\| mannose-6-phosphate isomerase [Yersinia pestis Pestoides A], gi\|2297... gi\|167425038, gi... - gi\|167425038\|ref\|ZP_02316791.1\| mannose-6-phosphate isomerase, class I [Yersinia pestis biovar Media... gi\|229897695, gi... - gi\|229897695\|ref\|ZP_04512851.1\| mannose-6-phosphate isomerase [Yersinia pestis biovar Orientalis str... gi\|162352938, gi... - gi\|162420123\|ref\|YP_001606711.1\| mannose-6-phosphate isomerase [Yersinia pestis Angola], gi\|16235293... gi\|165927440, gi... - gi\|165927440\|ref\|ZP_02223272.1\| mannose-6-phosphate isomerase, class I [Yersinia pestis biovar Orien... gi\|165913802, gi... - gi\|165938141\|ref\|ZP_02226700.1\| mannose-6-phosphate isomerase, class I [Yersinia pestis biovar Orien... gi\|165990355, gi... - gi\|166010653\|ref\|ZP_02231551.1\| mannose-6-phosphate isomerase, class I [Yersinia pestis biovar Antiq... gi\|45441857, gi\|... - gi\|45441857\|ref\|NP_993396.1\| mannose-6-phosphate isomerase [Yersinia pestis biovar Microtus str. 910... gi\|25292569 - pir\|\|AG0275 mannose-6-phosphate isomerase (EC 5.3.1.8) [imported] - Yersinia pestis (strain CO92) gi\|16122487, gi\|... - gi\|218929355\|ref\|YP_002347230.1\| mannose-6-phosphate isomerase [Yersinia pestis CO92], gi\|16122487\|r... gi\|149292235, gi... - gi\|149365822\|ref\|ZP_01887857.1\| mannose-6-phosphate isomerase [Yersinia pestis CA88-4125], gi\|149292...	459.0	[0..1]	[391..1]
gi\|30041377, gi\|... - gi\|30063128\|ref\|NP_837299.1\| mannose-6-phosphate isomerase [Shigella flexneri 2a str. 2457T], gi\|300... gi\|110615135, gi... - gi\|110805587\|ref\|YP_689107.1\| mannose-6-phosphate isomerase [Shigella flexneri 5 str. 8401], gi\|1106... gi\|56383493, gi\|... - gi\|56479942\|ref\|NP_707512.2\| mannose-6-phosphate isomerase [Shigella flexneri 2a str. 301], gi\|56383... MANA_SHIFL - Mannose-6-phosphate isomerase OS=Shigella flexneri GN=manA PE=3 SV=4	459.0	[0..1]	[391..1]

Back

Predicted Domain #1

Region A:
Residues: [1-391]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKLINSVQN YAWGSKTALT ELYGMENPSS QPMAELWMGA HPKSSSRVQN AAGDIVSLRD  60
   61 VIESDKSTLL GEAVAKRFGE LPFLFKVLCA AQPLSIQVHP NKHNSEIGFA KENAAGIPMD 120
  121 AAERNYKDPN HKPELVFALT PFLAMNAFRE FSEIVSLLQP VAGAHPAIAH FLQQPDAERL 180
  181 SELFASLLNM QGEEKSRALA ILKSALDSQQ GEPWQTIRLI SEFYPEDSGL FSPLLLNVVK 240
  241 LNPGEAMFLF AETPHAYLQG VALEVMANSD NVLRAGLTPK YIDIPELVAN VKFEAKPANQ 300
  301 LLTQPVKQGA ELDFPIPVDD FAFSLHDLSD KETTISQQSA AILFCVEGDA TLWKGSQQLQ 360
  361 LKPGESAFIA ANESPVTVKG HGRLARVYNK L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	92.69897
Match:	1pmiA
Description:	HUMAN RANTES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	1.86690435826277	bayes_pls_golite062009
nucleic acid binding	1.64913898350018	bayes_pls_golite062009
DNA binding	1.57178406956273	bayes_pls_golite062009
binding	1.54596514444405	bayes_pls_golite062009
transcription factor activity	0.937392765385803	bayes_pls_golite062009
intramolecular oxidoreductase activity	0.8581504516071	bayes_pls_golite062009
dTDP-4-dehydrorhamnose 3,5-epimerase activity	0.693650090282669	bayes_pls_golite062009
catalytic activity	0.401988496917198	bayes_pls_golite062009
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	0.353173877157675	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	0.348782780143283	bayes_pls_golite062009
protein binding	0.110960530780648	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: