YRC Public Data Repository - Protein Structure Prediction

Protein:	LYSR_ECOLI
Organism:	Escherichia coli
Length:	311 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LYSR_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|91191158, gi\|... - gi\|91224247\|ref\|ZP_01259510.1\| putative transcription regulator protein [Vibrio alginolyticus 12G01]...	286.0	[0..3]	[302..1]
gi\|28900071, gi\|... - gi\|28900071\|ref\|NP_799726.1\| putative transcription regulator protein [Vibrio parahaemolyticus RIMD ... gi\|28808354 - gi\|28808354\|dbj\|BAC61559.1\| putative transcription regulator protein [Vibrio parahaemolyticus RIMD 2...	284.0	[0..3]	[302..1]
gi\|116185384, gi... - gi\|75856032\|ref\|ZP_00763668.1\| COG0583: Transcriptional regulator [Vibrio sp. Ex25], gi\|254227935\|re...	284.0	[0..3]	[307..1]
gi\|114045851, gi... - gi\|78689367\|ref\|ZP_00854030.1\| transcriptional regulator, LysR family [Shewanella sp. MR-7], gi\|7851...	283.0	[0..3]	[296..1]
gi\|117614564, gi... - gi\|78685922\|ref\|ZP_00850696.1\| transcriptional regulator, LysR family [Shewanella sp. ANA-3], gi\|785...	281.0	[0..3]	[296..1]
gi\|82406257, gi\|... - gi\|82495665\|ref\|ZP_00881239.1\| transcriptional regulator, LysR family [Shewanella sp. MR-4], gi\|8240...	280.0	[0..3]	[295..1]
SO0369 - transcriptional regulator LysR family gi\|24345816, gi\|... - gi\|24371967\|ref\|NP_716009.1\| LysR family transcriptional regulator [Shewanella oneidensis MR-1], gi\|...	278.0	[0..3]	[297..1]
gi\|27367995, gi\|... - gi\|27367995\|ref\|NP_763522.1\| transcriptional regulator [Vibrio vulnificus CMCP6], gi\|27359568\|gb\|AAO...	277.0	[0..6]	[304..5]
gi\|37200667, gi\|... - gi\|37676126\|ref\|NP_936522.1\| transcriptional regulator [Vibrio vulnificus YJ016], gi\|37200667\|dbj\|BA...	276.0	[0..6]	[304..5]
gi\|82719568, gi\|... - gi\|82743075\|ref\|ZP_00905742.1\| transcriptional regulator, LysR family [Shewanella sp. W3-18-1], gi\|8...	272.0	[0..3]	[294..1]

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Predicted Domain #1

Region A:
Residues: [1-311]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAVNLRHIE IFHAVMTAGS LTEAAHLLHT SQPTVSRELA RFEKVIGLKL FERVRGRLHP  60
   61 TVQGLRLFEE VQRSWYGLDR IVSAAESLRE FRQGELSIAC LPVFSQSFLP QLLQPFLARY 120
  121 PDVSLNIVPQ ESPLLEEWLS AQRHDLGLTE TLHTPAGTER TELLSLDEVC VLPPGHPLAV 180
  181 KKVLTPDDFQ GENYISLSRT DSYRQLLDQL FTEHQVKRRM IVETHSAASV CAMVRAGVGI 240
  241 SVVNPLTALD YAASGLVVRR FSIAVPFTVS LIRPLHRPSS ALVQAFSGHL QAGLPKLVTS 300
  301 LDAILSSATT A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.045757
Match:	1al3A
Description:	COFACTOR BINDING FRAGMENT OF CYSB FROM KLEBSIELLA AEROGENES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	2.06846313752146	bayes_pls_golite062009
transcription factor activity	1.54776226622667	bayes_pls_golite062009
DNA binding	1.53867658911479	bayes_pls_golite062009
nucleic acid binding	1.45471488657915	bayes_pls_golite062009
binding	1.29220115989941	bayes_pls_golite062009
catalytic activity	1.04475291968158	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: