YRC Public Data Repository - Protein Structure Prediction

Protein:	LHR_ECOLI
Organism:	Escherichia coli
Length:	1538 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LHR_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|194426024, gi... - gi\|75212989\|ref\|ZP_00712987.1\| COG1201: Lhr-like helicases [Escherichia coli B171], gi\|194426024\|ref...	1490.0	[0..1]	[1538..1]
gi\|208731135, gi... - gi\|208816792\|ref\|ZP_03257912.1\| DEAD/DEAH box helicase family protein Lhr [Escherichia coli O157:H7 ... gi\|208810513, gi... - gi\|208810513\|ref\|ZP_03252389.1\| DEAD/DEAH box helicase family protein Lhr [Escherichia coli O157:H7 ... gi\|195940216 - gi\|195940216\|ref\|ZP_03085598.1\| putative ATP-dependent helicase Lhr [Escherichia coli O157:H7 str. E... gi\|189375327, gi... - gi\|189375327\|gb\|EDU93743.1\| DEAD/DEAH box helicase family protein Lhr [Escherichia coli O157:H7 str.... gi\|217318119, gi... - gi\|217328772\|ref\|ZP_03444853.1\| DEAD/DEAH box helicase family protein Lhr [Escherichia coli O157:H7 ... gi\|209398820, gi... - gi\|209398820\|ref\|YP_002270722.1\| DEAD/DEAH box helicase family protein Lhr [Escherichia coli O157:H7... gi\|254592670, gi... - gi\|254793270\|ref\|YP_003078107.1\| predicted ATP-dependent helicase [Escherichia coli O157:H7 str. TW1... gi\|15831616, gi\|... - gi\|15831616\|ref\|NP_310389.1\| putative ATP-dependent helicase Lhr [Escherichia coli O157:H7 str. Saka... gi\|168783925, gi... - gi\|188998817\|gb\|EDU67803.1\| DEAD/DEAH box helicase family protein Lhr [Escherichia coli O157:H7 str.... gi\|168775886, gi... - gi\|187768678\|gb\|EDU32522.1\| DEAD/DEAH box helicase family protein Lhr [Escherichia coli O157:H7 str.... gi\|189360029, gi... - gi\|189360029\|gb\|EDU78448.1\| DEAD/DEAH box helicase family protein Lhr [Escherichia coli O157:H7 str.... gi\|15831616, gi\|... - gi\|15831616\|ref\|NP_310389.1\| Lhr [Escherichia coli O157:H7], gi\|13361829\|dbj\|BAB35785.1\| probable AT... gi\|25390826, gi\|... - pir\|\|F85772 ATP-dependent helicase homolog [imported] - Escherichia coli (strain O157:H7, substrain ... gi\|12515648, gi\|... - gi\|15802067\|ref\|NP_288089.1\| putative ATP-dependent helicase Lhr [Escherichia coli O157:H7 EDL933], ...	1484.0	[0..1]	[1538..1]
gi\|191165940, gi... - gi\|75230899\|ref\|ZP_00717348.1\| COG1201: Lhr-like helicases [Escherichia coli B7A], gi\|191165940\|ref\|...	1482.0	[0..1]	[1538..1]
gi\|75234964, gi\|... - gi\|75234964\|ref\|ZP_00719243.1\| COG1201: Lhr-like helicases [Escherichia coli E110019], gi\|193070257\|...	1481.0	[0..1]	[1538..1]
gi\|75190692, gi\|... - gi\|75190692\|ref\|ZP_00703959.1\| COG1201: Lhr-like helicases [Escherichia coli E24377A], gi\|157158101\|...	1479.0	[0..1]	[1538..1]
gi\|83587987, gi\|... - gi\|83587987\|ref\|ZP_00926613.1\| COG1201: Lhr-like helicases [Escherichia coli 101-1], gi\|194436418\|re... gi\|242377383, gi... - gi\|251785110\|ref\|YP_002999414.1\| hypothetical protein B21_01613 [Escherichia coli BL21], gi\|24237738... gi\|254161715, gi... - gi\|254161715\|ref\|YP_003044823.1\| predicted ATP-dependent helicase [Escherichia coli B str. REL606], ... gi\|254288504, gi... - gi\|254288504\|ref\|YP_003054252.1\| predicted ATP-dependent helicase [Escherichia coli BL21(DE3)], gi\|2...	1479.0	[0..1]	[1538..1]
gi\|75512913 - gi\|75512913\|ref\|ZP_00735394.1\| COG1201: Lhr-like helicases [Escherichia coli 53638]	1477.0	[0..1]	[1538..1]
gi\|75195732 - gi\|75195732\|ref\|ZP_00705802.1\| COG1201: Lhr-like helicases [Escherichia coli HS]	1477.0	[0..1]	[1538..1]
gi\|75257072 - gi\|75257072\|ref\|ZP_00728632.1\| COG1201: Lhr-like helicases [Escherichia coli E22]	1411.0	[0..110]	[1538..2]
gi\|41409513, gi\|... - gi\|41409513\|ref\|NP_962349.1\| hypothetical protein MAP3415 [Mycobacterium avium subsp. paratuberculos...	1306.0	[0..1]	[1535..1]

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Predicted Domain #1

Region A:
Residues: [1-512]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADNPDPSSL LPDVFSPATR DWFLRAFKQP TAVQPQTWHV AARSEHALVI APTGSGKTLA  60
   61 AFLYALDRLF REGGEDTREA HKRKTSRILY ISPIKALGTD VQRNLQIPLK GIADERRRRG 120
  121 ETEVNLRVGI RTGDTPAQER SKLTRNPPDI LITTPESLYL MLTSRARETL RGVETVIIDE 180
  181 VHAVAGSKRG AHLALSLERL DALLHTSAQR IGLSATVRSA SDVAAFLGGD RPVTVVNPPA 240
  241 MRHPQIRIVV PVANMDDVSS VASGTGEDSH AGREGSIWPY IETGILDEVL RHRSTIVFTN 300
  301 SRGLAEKLTA RLNELYAARL QRSPSIAVDA AHFESTSGAT SNRVQSSDVF IARSHHGSVS 360
  361 KEQRAITEQA LKSGELRCVV ATSSLELGID MGAVDLVIQV ATPLSVASGL QRIGRAGHQV 420
  421 GGVSKGLFFP RTRRDLVDSA VIVECMFAGR LENLTPPHNP LDVLAQQTVA AAAMDALQVD 480
  481 EWYSRVRRAA PWKDLPRRVF DATLDMLSGR YP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.522879
Match:	2p6rA
Description:	No description for 2p6rA was found.

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.37148167194523	bayes_pls_golite062009
binding	0.556857559334679	bayes_pls_golite062009
hydrolase activity	0.310795123901245	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [513-691]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGDFSAFRPK LVWNRETGIL TARPGAQLLA VTSGGTIPDR GMYSVLLPEG EEKAGSRRVG  60
   61 ELDEEMVYES RVNDIITLGA TSWRIQQITR DQVIVTPAPG RSARLPFWRG EGNGRPAELG 120
  121 EMIGDFLHLL ADGAFFSGTI PPWLAEENTI ANIQGLIEEQ RNATGIVPGS RHLVLERCR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.522879
Match:	1tf2A
Description:	Crystal structure of SecA:ADP in an open conformation from Bacillus Subtilis
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [692-905]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEIGDWRIIL HSPYGRRVHE PWAVAIAGRI HALWGADASV VASDDGIVAR IPDTDGKLPD  60
   61 AAIFLFEPEK LLQIVREAVG SSALFAARFR ECAARALLMP GRTPGHRTPL WQQRLRASQL 120
  121 LEIAQGYPDF PVILETLREC LQDVYDLPAL ERLMRRLNGG EIQISDVTTT TPSPFATSLL 180
  181 FGYVAEFMYQ SDAPLAERRA SVLSLDSELL RNLL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	72.886057
Match:	PF08494.2
Description:	No description for PF08494.2 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [906-1007]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GQVDPGELLD PQVIRQVEEE LQRLAPGRRA KGEEGLFDLL RELGPMTVED LAQRHTGSSE  60
   61 EVASYLENLL AVKRIFPAMI SGQERLACMD DAARLRDALG VR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.383	a.39.1	EF-hand
View	Download	0.446	a.1.1	Globin-like
View	Download	0.488	c.48.1	TK C-terminal domain-like
View	Download	0.426	d.58.26	GHMP Kinase, C-terminal domain
View	Download	0.403	a.1.1	Globin-like

Predicted Domain #5

Region A:
Residues: [1008-1114]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPESLPEIYL HRVSYPLRDL FLRYLRAHAL VTAEQLAHEF SLGIAIVEEQ LQQLREQGLV  60
   61 MNLQQDIWVS DEVFRRLRLR SLQAAREATR PVAATTYARL LLERQGV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [1115-1292]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPATDGSPAL FASTSPGVYE GVDGVMRVIE QLAGVGLPAS LWESQILPAR VRDYSSEMLD  60
   61 ELLATGAVIW SGQKKLGEDD GLVALHLQEY AAESFTPAEA DQANRSALQQ AIVAVLADGG 120
  121 AWFAQQISQR IRDKIGESVD LSALQEALWA LVWQGVITSD IWAPLRALTR SSSNARTS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [1293-1538]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TRRSHRARRG RPVYAQPVSP RVSYNTPNLA GRWSLLQVEP LNDTERMLAL AENMLDRYGI  60
   61 ISRQAVIAEN IPGGFPSMQT LCRSMEDSGR IMRGRFVEGL GGAQFAERLT IDRLRDLATQ 120
  121 ATQTRHYTPV ALSANDPANV WGNLLPWPAH PATLVPTRRA GALVVVSGGK LLLYLAQGGK 180
  181 KMLVWQEKEE LLAPEVFHAL TTALRREPRL RFTLTEVNDL PVRQTPMFTL LREAGFSSSP 240
  241 QGLDWG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: