YRC Public Data Repository - Protein Structure Prediction

Protein:	KTHY_ECOLI
Organism:	Escherichia coli
Length:	213 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KTHY_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|1246364 - gi\|1246364\|gb\|AAA93513.1\| thymidylate:zeocin resistance protein:NDP kinase fusion protein [Cloning v...	187.0	[0..2]	[213..3]
gi\|1246361 - gi\|1246361\|gb\|AAA93511.1\| thymidine:thymidylate kinase:zeocin resistance fusion protein [Cloning vec...	185.0	[0..2]	[213..217]
KTHY_ECOK1 - Thymidylate kinase OS=Escherichia coli O1:K1 / APEC GN=tmk PE=3 SV=1 gi\|226898127, gi... - gi\|237706917\|ref\|ZP_04537398.1\| thymidylate kinase [Escherichia sp. 3_2_53FAA], gi\|226898127\|gb\|EEH8... KTHY_ECOUT - Thymidylate kinase OS=Escherichia coli (strain UTI89 / UPEC) GN=tmk PE=3 SV=1 KTHY_ECO45 - Thymidylate kinase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=tmk PE=3 SV=1	183.0	[0..1]	[213..1]
gi\|227836750, gi... - gi\|227886546\|ref\|ZP_04004351.1\| thymidylate kinase [Escherichia coli 83972], gi\|227836750\|gb\|EEJ4721... KTHY_ECOL6 - Thymidylate kinase OS=Escherichia coli O6 GN=tmk PE=3 SV=1 KTHY_ECOL6 - Thymidylate kinase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=tmk PE=3 SV=1	183.0	[0..1]	[213..1]
gi\|75235726, gi\|... - gi\|75235726\|ref\|ZP_00719896.1\| COG0125: Thymidylate kinase [Escherichia coli F11], gi\|191174621\|ref\|... KTHY_ECO27 - Thymidylate kinase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=tmk PE=3 SV=1 KTHY_ECOL5 - Thymidylate kinase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=tmk PE=3 SV=1 KTHY_ECOLU - Thymidylate kinase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=tmk PE=3 SV=1 sp\|B7UPB4\|KTHY_ECO27 - Thymidylate kinase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=tmk PE=3 SV=1	182.0	[0..1]	[213..1]
gi\|6729850, gi\|6... - gi\|6729850\|pdb\|5TMP\|A Chain A, Complex Of E. Coli Thymidylate Kinase With The Bisubstrate Inhibitor ...	181.0	[0..1]	[213..1]
KTHY_ECO57 - Thymidylate kinase OS=Escherichia coli O157:H7 GN=tmk PE=3 SV=1 gi\|25288287, gi\|... - pir\|\|H85672 thymidylate kinase [imported] - Escherichia coli (strain O157:H7, substrain EDL933), pi... gi\|13360940, gi\|... - gi\|15830730\|ref\|NP_309503.1\| thymidylate kinase [Escherichia coli O157:H7 str. Sakai], gi\|13360940\|d... gi\|217328521, gi... - gi\|217328521\|ref\|ZP_03444603.1\| thymidylate kinase [Escherichia coli O157:H7 str. TW14588], gi\|21731... gi\|12514642, gi\|... - gi\|15801215\|ref\|NP_287232.1\| thymidylate kinase [Escherichia coli O157:H7 EDL933], gi\|12514642\|gb\|AA... gi\|254792480, gi... - gi\|254792480\|ref\|YP_003077317.1\| thymidylate kinase [Escherichia coli O157:H7 str. TW14359], gi\|2545... gi\|208727593, gi... - gi\|208807792\|ref\|ZP_03250129.1\| thymidylate kinase [Escherichia coli O157:H7 str. EC4206], gi\|208727... gi\|208732381, gi... - gi\|208815733\|ref\|ZP_03256912.1\| thymidylate kinase [Escherichia coli O157:H7 str. EC4045], gi\|208732... gi\|208737885, gi... - gi\|208822400\|ref\|ZP_03262719.1\| thymidylate kinase [Escherichia coli O157:H7 str. EC4042], gi\|208737... KTHY_ECO5E - Thymidylate kinase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=tmk PE=3 SV=1 gi\|195938857 - gi\|195938857\|ref\|ZP_03084239.1\| thymidylate kinase [Escherichia coli O157:H7 str. EC4024]	181.0	[0..1]	[213..1]
gi\|84326490 - gi\|84326490\|ref\|ZP_00974517.1\| COG0125: Thymidylate kinase [Pseudomonas aeruginosa 2192]	180.0	[0..1]	[208..1]
gi\|89074515, gi\|... - gi\|89074515\|ref\|ZP_01160987.1\| putative thymidylate kinase [Photobacterium sp. SKA34], gi\|89049619\|g...	179.0	[0..1]	[210..1]
gi\|90579079, gi\|... - gi\|90579079\|ref\|ZP_01234889.1\| putative thymidylate kinase [Vibrio angustum S14], gi\|90439912\|gb\|EAS...	179.0	[0..1]	[209..1]

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Predicted Domain #1

Region A:
Residues: [1-213]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSKYIVIEG LEGAGKTTAR NVVVETLEQL GIRDMVFTRE PGGTQLAEKL RSLVLDIKSV  60
   61 GDEVITDKAE VLMFYAARVQ LVETVIKPAL ANGTWVIGDR HDLSTQAYQG GGRGIDQHML 120
  121 ATLRDAVLGD FRPDLTLYLD VTPEVGLKRA RARGELDRIE QESFDFFNRT RARYLELAAQ 180
  181 DKSIHTIDAT QPLEAVMDAI RTTVTHWVKE LDA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.0
Match:	4tmkA
Description:	Thymidylate kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleobase, nucleoside, nucleotide kinase activity	3.31021342806183	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.01286198424677	bayes_pls_golite062009
nucleotide kinase activity	2.24094813695083	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.06460241490722	bayes_pls_golite062009
substrate-specific transporter activity	2.0114051513686	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	1.96697952975573	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.92626167278464	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.9136419736217	bayes_pls_golite062009
ion transmembrane transporter activity	1.6854386921174	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.64467072658718	bayes_pls_golite062009
kinase activity	1.60827037072506	bayes_pls_golite062009
cation transmembrane transporter activity	1.5008821138859	bayes_pls_golite062009
binding	1.25659194713805	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
nucleotide binding	0.828524126097217	bayes_pls_golite062009
purine ribonucleotide binding	0.810407092593521	bayes_pls_golite062009
ribonucleotide binding	0.810379637652019	bayes_pls_golite062009
purine nucleotide binding	0.805605269661092	bayes_pls_golite062009
hydrolase activity	0.420858111948277	bayes_pls_golite062009
adenylate kinase activity	0.373057703057608	bayes_pls_golite062009
nucleic acid binding	0.216266069700019	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: