YRC Public Data Repository - Protein Structure Prediction

Protein:	INTS_ECOLI
Organism:	Escherichia coli
Length:	385 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for INTS_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77974232, gi\|... - gi\|77974232\|ref\|ZP_00829773.1\| COG0582: Integrase [Yersinia frederiksenii ATCC 33641], gi\|238790928\|...	282.0	[0..2]	[383..3]
gi\|77962153, gi\|... - gi\|77962153\|ref\|ZP_00825977.1\| COG0582: Integrase [Yersinia mollaretii ATCC 43969], gi\|238795435\|ref...	280.0	[0..2]	[383..3]
gi\|190902162, gi... - gi\|75229050\|ref\|ZP_00715634.1\| COG0582: Integrase [Escherichia coli B7A], gi\|191167819\|ref\|ZP_030296...	280.0	[0..2]	[383..3]
gi\|253975488, gi... - gi\|254163587\|ref\|YP_003046695.1\| Int [Escherichia coli B str. REL606], gi\|253975488\|gb\|ACT41159.1\| I... gi\|194435929, gi... - gi\|83588494\|ref\|ZP_00927118.1\| COG0582: Integrase [Escherichia coli 101-1], gi\|194435929\|ref\|ZP_0306... gi\|57545625 - gi\|57545625\|gb\|AAW51716.1\| Int [Escherichia coli] gi\|26250313, gi\|... - gi\|26250313\|ref\|NP_756353.1\| putative prophage integrase [Escherichia coli CFT073], gi\|26110743\|gb\|A... gi\|251786909, gi... - gi\|251786909\|ref\|YP_003001213.1\| hypothetical protein B21_03468 [Escherichia coli BL21], gi\|24237918... gi\|254290337, gi... - gi\|254290337\|ref\|YP_003056085.1\| Int [Escherichia coli BL21(DE3)], gi\|253979644\|gb\|ACT45314.1\| Int [...	279.0	[0..2]	[383..3]
gi\|87307430, gi\|... - gi\|87307430\|ref\|ZP_01089574.1\| probable cp4-like integrase protein [Blastopirellula marina DSM 3645]...	279.0	[0..2]	[384..3]
gi\|14252927 - gi\|14252927\|emb\|CAC39282.1\| integrase [Escherichia coli]	278.0	[0..2]	[383..3]
gi\|75194504, gi\|... - gi\|75194504\|ref\|ZP_00704574.1\| COG0582: Integrase [Escherichia coli HS], gi\|157159783\|ref\|YP_0014571...	277.0	[0..2]	[382..3]
tr\|A0A0G3HSD6\|A0... - CPS-53 (KpLE1) prophage putative prophageCPS-53 integrase protein OS=Escherichia coli (strain K12) G... gi\|91073219, gi\|... - gi\|91211645\|ref\|YP_541631.1\| prophage integrase [Escherichia coli UTI89], gi\|91073219\|gb\|ABE08100.1\|... gi\|237704827, gi... - gi\|237704827\|ref\|ZP_04535308.1\| prophage integrase [Escherichia sp. 3_2_53FAA], gi\|226901193\|gb\|EEH8...	277.0	[0..1]	[385..13]
gi\|74314106, gi\|... - gi\|74314106\|ref\|YP_312525.1\| putative integrase [Shigella sonnei Ss046], gi\|73857583\|gb\|AAZ90290.1\| ...	277.0	[0..2]	[383..3]
gi\|13559824, gi\|... - gi\|13559824\|ref\|NP_112034.1\| integrase [Enterobacteria phage HK620], gi\|13517560\|gb\|AAK28849.1\|AF335...	276.0	[0..1]	[385..1]

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Predicted Domain #1

Region A:
Residues: [1-385]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTVKQIEAA KPKEKPYRLL DGNGLYLYVP VSGKKVWQLR YKIDGKEKIL TVGKYPLMTL  60
   61 QEARDKAWTA RKDISVGIDP VKAKKASSNN NSFSAIYKEW YEHKKQVWSV GYATELAKMF 120
  121 DDDILPIIGG LEIQDIEPMQ LLEVIRRFED RGAMERANKA RRRCGEVFRY AIVTGRAKYN 180
  181 PAPDLADAMK GYRKKNFPFL PADQIPAFNK ALATFSGSIV SLIATKVLRY TALRTKELRS 240
  241 MLWKNVDFEN RIITIDASVM KGRKIHVVPM SDQVVELLTT LSSITKPVSE FVFAGRNDKK 300
  301 KPICENAVLL VIKQIGYEGL ESGHGFRHEF STIMNEHEWP ADAIEVQLAH ANGGSVRGIY 360
  361 NHAQYLDKRR EMMQWWADWL DEKVE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.221849
Match:	1z1bA
Description:	Crystal structure of a lambda integrase dimer bound to a COC' core site
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
structure-specific DNA binding	2.96794540657137	bayes_pls_golite062009
chromatin binding	2.66956311972752	bayes_pls_golite062009
catalytic activity	1.85476765215403	bayes_pls_golite062009
double-stranded DNA binding	1.47056442077417	bayes_pls_golite062009
DNA binding	1.08208472364243	bayes_pls_golite062009
nucleic acid binding	1.01945666037816	bayes_pls_golite062009
sequence-specific DNA binding	0.88630365094839	bayes_pls_golite062009
binding	0.849061082531999	bayes_pls_golite062009
methyl-CpG binding	0.644006146507516	bayes_pls_golite062009
transcription regulator activity	0.433129028335043	bayes_pls_golite062009
protein binding	0.391840757563427	bayes_pls_golite062009
DNA secondary structure binding	0.32168641878414	bayes_pls_golite062009
transcription factor activity	0.135216468398819	bayes_pls_golite062009
transcription factor binding	0.0858654055973298	bayes_pls_golite062009
four-way junction DNA binding	0.0788334929658094	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: