YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS8_ECOLI
Organism:	Escherichia coli
Length:	356 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS8_ECOLI.

Description	E-value	Query Range	Subject Range
AAT1_BACSU - Aspartate aminotransferase OS=Bacillus subtilis GN=aspB PE=3 SV=1 AAT1_BACSU - Aspartate aminotransferase OS=Bacillus subtilis (strain 168) GN=aspB PE=3 SV=1 gi\|221314475 - gi\|221314475\|ref\|ZP_03596280.1\| aspartate aminotransferase [Bacillus subtilis subsp. subtilis str. N... gi\|221319397 - gi\|221319397\|ref\|ZP_03600691.1\| aspartate aminotransferase [Bacillus subtilis subsp. subtilis str. J... gi\|221323673 - gi\|221323673\|ref\|ZP_03604967.1\| aspartate aminotransferase [Bacillus subtilis subsp. subtilis str. S...	317.0	[0..3]	[355..4]
gi\|42780748, gi\|... - gi\|42780748\|ref\|NP_977995.1\| aspartate aminotransferase [Bacillus cereus ATCC 10987], gi\|42736668\|gb...	308.0	[0..3]	[355..4]
gi\|228656558, gi... - gi\|229126958\|ref\|ZP_04255969.1\| Aspartate aminotransferase [Bacillus cereus BDRD-Cer4], gi\|228656558... gi\|29895237, gi\|... - gi\|30019693\|ref\|NP_831324.1\| aspartate aminotransferase [Bacillus cereus ATCC 14579], gi\|29895237\|gb...	308.0	[0..3]	[355..4]
gi\|228984724, gi... - gi\|228984724\|ref\|ZP_04144896.1\| Aspartate aminotransferase [Bacillus thuringiensis serovar tochigien... gi\|228628337, gi... - gi\|229155210\|ref\|ZP_04283322.1\| Aspartate aminotransferase [Bacillus cereus ATCC 4342], gi\|228628337... gi\|47566009, gi\|... - gi\|47566009\|ref\|ZP_00237047.1\| aspartate aminotransferase [Bacillus cereus G9241], gi\|47556926\|gb\|EA...	308.0	[0..3]	[355..4]
AAT_AQUAE - Aspartate aminotransferase OS=Aquifex aeolicus (strain VF5) GN=aspC PE=3 SV=1 AAT_AQUAE - Aspartate aminotransferase OS=Aquifex aeolicus GN=aspC PE=3 SV=1	307.0	[0..3]	[355..6]
gi\|118477096, gi... - gi\|118477096\|ref\|YP_894247.1\| aspartate aminotransferase [Bacillus thuringiensis str. Al Hakam], gi\|... gi\|167531298, gi... - gi\|167633260\|ref\|ZP_02391585.1\| aspartate aminotransferase [Bacillus anthracis str. A0442], gi\|16753... gi\|164714877, gi... - gi\|165869437\|ref\|ZP_02214096.1\| aspartate aminotransferase [Bacillus anthracis str. A0488], gi\|16471... gi\|225786881, gi... - gi\|225863508\|ref\|YP_002748886.1\| aspartate aminotransferase [Bacillus cereus 03BB102], gi\|225786881\|... gi\|227003591, gi... - gi\|227815608\|ref\|YP_002815617.1\| aspartate aminotransferase [Bacillus anthracis str. CDC 684], gi\|22... gi\|228914220, gi... - gi\|228914220\|ref\|ZP_04077836.1\| Aspartate aminotransferase [Bacillus thuringiensis serovar pulsiensi... gi\|228833051, gi... - gi\|228926675\|ref\|ZP_04089744.1\| Aspartate aminotransferase [Bacillus thuringiensis serovar pondicher... gi\|228826736, gi... - gi\|228932933\|ref\|ZP_04095798.1\| Aspartate aminotransferase [Bacillus thuringiensis serovar andalousi... gi\|228814479, gi... - gi\|228945244\|ref\|ZP_04107600.1\| Aspartate aminotransferase [Bacillus thuringiensis serovar monterrey... gi\|228662306, gi... - gi\|229121187\|ref\|ZP_04250424.1\| Aspartate aminotransferase [Bacillus cereus 95/8201], gi\|228662306\|g... gi\|228599688, gi... - gi\|229183839\|ref\|ZP_04311056.1\| Aspartate aminotransferase [Bacillus cereus BGSC 6E1], gi\|228599688\|... gi\|229266533, gi... - gi\|229602125\|ref\|YP_002866048.1\| aspartate aminotransferase [Bacillus anthracis str. A0248], gi\|2292... gi\|254723720 - gi\|254723720\|ref\|ZP_05185506.1\| aspartate aminotransferase [Bacillus anthracis str. A1055] gi\|254734481 - gi\|254734481\|ref\|ZP_05192193.1\| aspartate aminotransferase [Bacillus anthracis str. Western North Am... gi\|254740892 - gi\|254740892\|ref\|ZP_05198580.1\| aspartate aminotransferase [Bacillus anthracis str. Kruger B] gi\|170128600, gi... - gi\|170706502\|ref\|ZP_02896962.1\| aspartate aminotransferase [Bacillus anthracis str. A0389], gi\|17012... gi\|254755131 - gi\|254755131\|ref\|ZP_05207165.1\| aspartate aminotransferase [Bacillus anthracis str. Vollum] gi\|167639102, gi... - gi\|167639102\|ref\|ZP_02397375.1\| aspartate aminotransferase [Bacillus anthracis str. A0193], gi\|16751... gi\|254759668 - gi\|254759668\|ref\|ZP_05211692.1\| aspartate aminotransferase [Bacillus anthracis str. Australia 94] gi\|190568685, gi... - gi\|190568685\|ref\|ZP_03021590.1\| aspartate aminotransferase [Bacillus anthracis Tsiankovskii-I], gi\|1... gi\|172083508, gi... - gi\|177650364\|ref\|ZP_02933331.1\| aspartate aminotransferase [Bacillus anthracis str. A0174], gi\|17208... gi\|196030164, gi... - gi\|196039019\|ref\|ZP_03106326.1\| aspartate aminotransferase [Bacillus cereus NVH0597-99], gi\|19603016... gi\|195993859, gi... - gi\|196033425\|ref\|ZP_03100837.1\| aspartate aminotransferase [Bacillus cereus W], gi\|195993859\|gb\|EDX5... gi\|218902756, gi... - gi\|218902756\|ref\|YP_002450590.1\| aspartate aminotransferase [Bacillus cereus AH820], gi\|218539609\|gb... gi\|196046666, gi... - gi\|196046666\|ref\|ZP_03113890.1\| aspartate aminotransferase [Bacillus cereus 03BB108], gi\|196022599\|g... gi\|49332551, gi\|... - gi\|49480995\|ref\|YP_035760.1\| aspartate aminotransferase [Bacillus thuringiensis serovar konkukian st... gi\|52143804, gi\|... - gi\|52143804\|ref\|YP_083024.1\| aspartate aminotransferase [Bacillus cereus E33L], gi\|51977273\|gb\|AAU18... gi\|50082989, gi\|... - gi\|50196927\|ref\|YP_052621.1\| aspartate aminotransferase [Bacillus anthracis str. 'Ames Ancestor'], g... gi\|49184471, gi\|... - gi\|49184471\|ref\|YP_027723.1\| aspartate aminotransferase [Bacillus anthracis str. Sterne], gi\|4917839... gi\|21399462, gi\|... - gi\|65318911\|ref\|ZP_00391870.1\| COG0436: Aspartate/tyrosine/aromatic aminotransferase [Bacillus anthr... gi\|30255869, gi\|... - gi\|30261641\|ref\|NP_844018.1\| aspartate aminotransferase [Bacillus anthracis str. Ames], gi\|30255869\|...	307.0	[0..3]	[355..4]
gi\|228859394, gi... - gi\|228900225\|ref\|ZP_04064456.1\| Aspartate aminotransferase [Bacillus thuringiensis IBL 4222], gi\|228... gi\|75760397, gi\|... - gi\|75760397\|ref\|ZP_00740441.1\| Aspartate aminotransferase [Bacillus thuringiensis serovar israelensi...	306.0	[0..3]	[355..4]
gi\|163861658, gi... - gi\|89204918\|ref\|ZP_01183493.1\| Aminotransferase, class I and II [Bacillus weihenstephanensis KBAB4],... gi\|228617065, gi... - gi\|229166491\|ref\|ZP_04294247.1\| Aspartate aminotransferase [Bacillus cereus AH621], gi\|228617065\|gb\|... gi\|228651159, gi... - gi\|229132453\|ref\|ZP_04261307.1\| Aspartate aminotransferase [Bacillus cereus BDRD-ST196], gi\|22865115...	305.0	[0..3]	[355..4]
gi\|25315638 - pir\|\|G83861 aspartate aminotransferase aspB [imported] - Bacillus halodurans (strain C-125) gi\|10174312, gi\|... - gi\|15614258\|ref\|NP_242561.1\| aspartate aminotransferase [Bacillus halodurans C-125], gi\|10174312\|dbj...	305.0	[0..3]	[354..4]
gi\|17936079, gi\|... - gi\|17936079\|ref\|NP_532869.1\| aspartate aminotransferase [Agrobacterium tumefaciens str. C58], gi\|177... gi\|25315751, gi\|... - pir\|\|AC2846 aspartate aminotransferase A [imported] - Agrobacterium tumefaciens (strain C58, Dupont)...	304.0	[0..6]	[355..8]

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Predicted Domain #1

Region A:
Residues: [1-356]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTVTITDLA RENVRNLTPY QSARRLGGNG DVWLNANEYP TAVEFQLTQQ TLNRYPECQP  60
   61 KAVIENYAQY AGVKPEQVLV SRGADEGIEL LIRAFCEPGK DAILYCPPTY GMYSVSAETI 120
  121 GVECRTVPTL DNWQLDLQGI SDKLDGVKVV YVCSPNNPTG QLINPQDFRT LLELTRGKAI 180
  181 VVADEAYIEF CPQASLAGWL AEYPHLAILR TLSKAFALAG LRCGFTLANE EVINLLMKVI 240
  241 APYPLSTPVA DIAAQALSPQ GIVAMRERVA QIIAEREYLI AALKEIPCVE QVFDSETNYI 300
  301 LARFKASSAV FKSLWDQGII LRDQNKQPSL SGCLRITVGT REESQRVIDA LRAEQV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	78.154902
Match:	1fg3A
Description:	Histidinol-phosphate aminotransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.29878871754893	bayes_pls_golite062009
transferase activity	1.44093490824786	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
histidinol-phosphate transaminase activity	1.26617748508821	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity	0.81652984148807	bayes_pls_golite062009
5-aminolevulinate synthase activity	0.802089219704558	bayes_pls_golite062009
intramolecular transferase activity, transferring amino groups	0.659071155545801	bayes_pls_golite062009
binding	0.536634592992536	bayes_pls_golite062009
pyridoxal phosphate binding	0.16957228630576	bayes_pls_golite062009
vitamin B6 binding	0.16957228630576	bayes_pls_golite062009
nucleic acid binding	0.013097682076602	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: