YRC Public Data Repository - Protein Structure Prediction

Protein:	HFLX_ECOLI
Organism:	Escherichia coli
Length:	426 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HFLX_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|151937416, gi... - gi\|75855418\|ref\|ZP_00763069.1\| COG2262: GTPases [Vibrio sp. Ex25], gi\|254230082\|ref\|ZP_04923480.1\| G... gi\|91188602, gi\|... - gi\|91227452\|ref\|ZP_01261816.1\| GTP-binding protein HflX [Vibrio alginolyticus 12G01], gi\|91188602\|gb...	370.0	[0..1]	[426..1]
gi\|156972473, gi... - gi\|156972473\|ref\|YP_001443380.1\| putative GTPase HflX [Vibrio harveyi ATCC BAA-1116], gi\|156524067\|g... gi\|47933919 - gi\|47933919\|gb\|AAT39525.1\| HflX [Vibrio harveyi]	370.0	[0..1]	[426..1]
gi\|226901752, gi... - gi\|237703840\|ref\|ZP_04534321.1\| GTP-binding protein hflX [Escherichia sp. 3_2_53FAA], gi\|226901752\|g... gi\|227836357, gi... - gi\|227886784\|ref\|ZP_04004589.1\| GTPase HflX [Escherichia coli 83972], gi\|227836357\|gb\|EEJ46823.1\| GT... gi\|26111497, gi\|... - gi\|26251065\|ref\|NP_757105.1\| putative GTPase HflX [Escherichia coli CFT073], gi\|26111497\|gb\|AAN83679... gi\|170766941, gi... - gi\|170766941\|ref\|ZP_02901394.1\| GTP-binding protein HflX [Escherichia albertii TW07627], gi\|17012437... gi\|215489517, gi... - gi\|215489517\|ref\|YP_002331948.1\| putative GTPase HflX [Escherichia coli O127:H6 str. E2348/69], gi\|2... gi\|218368101, gi... - gi\|218561332\|ref\|YP_002394245.1\| putative GTPase HflX [Escherichia coli S88], gi\|218368101\|emb\|CAR05... gi\|91075296, gi\|... - gi\|91213722\|ref\|YP_543708.1\| putative GTPase HflX [Escherichia coli UTI89], gi\|91075296\|gb\|ABE10177.... gi\|218692507, gi... - gi\|218692507\|ref\|YP_002400719.1\| putative GTPase HflX [Escherichia coli ED1a], gi\|218430071\|emb\|CAR1... gi\|110644530, gi... - gi\|110644530\|ref\|YP_672260.1\| putative GTPase HflX [Escherichia coli 536], gi\|110346122\|gb\|ABG72359.... gi\|190905206, gi... - gi\|75236174\|ref\|ZP_00720296.1\| COG2262: GTPases [Escherichia coli F11], gi\|191174526\|ref\|ZP_03036024...	368.0	[0..1]	[426..1]
gi\|28807826, gi\|... - gi\|28899590\|ref\|NP_799195.1\| putative GTPase HflX [Vibrio parahaemolyticus RIMD 2210633], gi\|2880782... gi\|28807826 - gi\|28807826\|dbj\|BAC61079.1\| GTP-binding protein HflX [Vibrio parahaemolyticus RIMD 2210633]	368.0	[0..1]	[426..1]
gi\|81243593, gi\|... - gi\|82779445\|ref\|YP_405794.1\| putative GTPase HflX [Shigella dysenteriae Sd197], gi\|81243593\|gb\|ABB64...	368.0	[0..1]	[426..1]
gi\|13364626, gi\|... - gi\|15834403\|ref\|NP_313176.1\| putative GTPase HflX [Escherichia coli O157:H7 str. Sakai], gi\|13364626... gi\|209750274, gi... - pir\|\|E86113 hypothetical protein hflX [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|12519158, gi\|... - gi\|15804762\|ref\|NP_290803.1\| putative GTPase HflX [Escherichia coli O157:H7 EDL933], gi\|12519158\|gb\|... gi\|13364626, gi\|... - gi\|15834403\|ref\|NP_313176.1\| GTP-binding subunit of protease specific for phage lambda cII repressor... gi\|124528232, gi... - gi\|124528232\|ref\|ZP_01699556.1\| GTP-binding protein, HSR1-related [Escherichia coli B], gi\|124500674... gi\|254595592, gi... - gi\|254796192\|ref\|YP_003081029.1\| predicted GTPase [Escherichia coli O157:H7 str. TW14359], gi\|254595... gi\|254164102, gi... - gi\|254164102\|ref\|YP_003047210.1\| predicted GTPase [Escherichia coli B str. REL606], gi\|253976003\|gb\|... gi\|226840293, gi... - gi\|254037187\|ref\|ZP_04871264.1\| GTP-binding protein HflX [Escherichia sp. 1_1_43], gi\|226840293\|gb\|E... gi\|254290852, gi... - gi\|254290852\|ref\|YP_003056600.1\| predicted GTPase [Escherichia coli BL21(DE3)], gi\|253980159\|gb\|ACT4... gi\|251787422, gi... - gi\|251787422\|ref\|YP_003001726.1\| hypothetical protein B21_04002 [Escherichia coli BL21], gi\|24237969... gi\|168780603, gi... - gi\|189001638\|gb\|EDU70624.1\| GTP-binding protein HflX [Escherichia coli O157:H7 str. EC4076], gi\|1687... gi\|168784808, gi... - gi\|189374971\|gb\|EDU93387.1\| GTP-binding protein HflX [Escherichia coli O157:H7 str. EC869], gi\|16878... gi\|189376070, gi... - gi\|189376070\|gb\|EDU94486.1\| GTP-binding protein HflX [Escherichia coli O157:H7 str. EC508], gi\|16880... gi\|170021817, gi... - gi\|170021817\|ref\|YP_001726771.1\| putative GTPase HflX [Escherichia coli ATCC 8739], gi\|169756745\|gb\|... gi\|170681964, gi... - gi\|170681964\|ref\|YP_001746568.1\| GTP-binding protein HflX [Escherichia coli SMS-3-5], gi\|170519682\|g... gi\|194417185, gi... - gi\|194434600\|ref\|ZP_03066857.1\| GTP-binding protein HflX [Shigella dysenteriae 1012], gi\|194417185\|g... gi\|195935963 - gi\|195935963\|ref\|ZP_03081345.1\| putative GTPase HflX [Escherichia coli O157:H7 str. EC4024] gi\|208727278, gi... - gi\|208807477\|ref\|ZP_03249814.1\| GTP-binding protein HflX [Escherichia coli O157:H7 str. EC4206], gi\|... gi\|168751477, gi... - gi\|188014507\|gb\|EDU52629.1\| GTP-binding protein HflX [Escherichia coli O157:H7 str. EC4113], gi\|1687... gi\|168754742, gi... - gi\|189357854\|gb\|EDU76273.1\| GTP-binding protein HflX [Escherichia coli O157:H7 str. EC4401], gi\|1687... gi\|168766450, gi... - gi\|189364080\|gb\|EDU82499.1\| GTP-binding protein HflX [Escherichia coli O157:H7 str. EC4486], gi\|1687... gi\|168774116, gi... - gi\|187770244\|gb\|EDU34088.1\| GTP-binding protein HflX [Escherichia coli O157:H7 str. EC4196], gi\|1687... gi\|191165587, gi... - gi\|75231234\|ref\|ZP_00717641.1\| COG2262: GTPases [Escherichia coli B7A], gi\|191165587\|ref\|ZP_03027427... gi\|218702870, gi... - gi\|218702870\|ref\|YP_002410499.1\| putative GTPase HflX [Escherichia coli IAI39], gi\|218372856\|emb\|CAR... gi\|192955819, gi... - gi\|75234278\|ref\|ZP_00718666.1\| COG2262: GTPases [Escherichia coli E110019], gi\|193070873\|ref\|ZP_0305... gi\|218707784, gi... - gi\|218707784\|ref\|YP_002415303.1\| putative GTPase HflX [Escherichia coli UMN026], gi\|218434881\|emb\|CA... gi\|157163636, gi... - gi\|75198019\|ref\|ZP_00708089.1\| COG2262: GTPases [Escherichia coli HS], gi\|157163636\|ref\|YP_001460954... gi\|194415347, gi... - gi\|75212278\|ref\|ZP_00712318.1\| COG2262: GTPases [Escherichia coli B171], gi\|194426608\|ref\|ZP_0305916... gi\|74314658, gi\|... - gi\|74314658\|ref\|YP_313077.1\| putative GTPase HflX [Shigella sonnei Ss046], gi\|73858135\|gb\|AAZ90842.1... gi\|75255900, gi\|... - gi\|75255900\|ref\|ZP_00727632.1\| COG2262: GTPases [Escherichia coli E22], gi\|193066018\|ref\|ZP_03047076... gi\|75515412, gi\|... - gi\|75515412\|ref\|ZP_00737569.1\| COG2262: GTPases [Escherichia coli 53638], gi\|188496314\|ref\|ZP_030035... gi\|208813758, gi... - gi\|208813758\|ref\|ZP_03255087.1\| GTP-binding protein HflX [Escherichia coli O157:H7 str. EC4045], gi\|... gi\|208819504, gi... - gi\|208819504\|ref\|ZP_03259824.1\| GTP-binding protein HflX [Escherichia coli O157:H7 str. EC4042], gi\|... gi\|209157981, gi... - gi\|209396581\|ref\|YP_002273715.1\| GTP-binding protein HflX [Escherichia coli O157:H7 str. EC4115], gi... gi\|209921661, gi... - gi\|209921661\|ref\|YP_002295745.1\| putative GTPase HflX [Escherichia coli SE11], gi\|209914920\|dbj\|BAG7... gi\|194439513, gi... - gi\|83585089\|ref\|ZP_00923742.1\| COG2262: GTPases [Escherichia coli 101-1], gi\|194439513\|ref\|ZP_030715... gi\|217321579, gi... - gi\|217325358\|ref\|ZP_03441442.1\| GTP-binding protein HflX [Escherichia coli O157:H7 str. TW14588], gi... gi\|157155239, gi... - gi\|75188884\|ref\|ZP_00702151.1\| COG2262: GTPases [Escherichia coli E24377A], gi\|157155239\|ref\|YP_0014... gi\|218551443, gi... - gi\|218551443\|ref\|YP_002385235.1\| putative GTPase HflX [Escherichia fergusonii ATCC 35469], gi\|218358... gi\|218556725, gi... - gi\|218556725\|ref\|YP_002389639.1\| putative GTPase HflX [Escherichia coli IAI1], gi\|218363494\|emb\|CAR0... gi\|218697922, gi... - gi\|218697922\|ref\|YP_002405589.1\| putative GTPase HflX [Escherichia coli 55989], gi\|218354654\|emb\|CAV...	368.0	[0..1]	[426..1]
gi\|187731219, gi... - gi\|75179456\|ref\|ZP_00699460.1\| COG2262: GTPases [Shigella boydii BS512], gi\|187731219\|ref\|YP_0018828... gi\|81247997, gi\|... - gi\|82546586\|ref\|YP_410533.1\| putative GTPase HflX [Shigella boydii Sb227], gi\|81247997\|gb\|ABB68705.1...	367.0	[0..1]	[426..1]
gi\|147673365, gi... - gi\|75828333\|ref\|ZP_00757768.1\| COG2262: GTPases [Vibrio cholerae O395], gi\|227116754\|ref\|YP_00281865...	367.0	[0..1]	[426..1]
gi\|24115528, gi\|... - gi\|24115528\|ref\|NP_710038.1\| putative GTPase HflX [Shigella flexneri 2a str. 301], gi\|24054856\|gb\|AA... gi\|30065545, gi\|... - gi\|30065545\|ref\|NP_839716.1\| putative GTPase HflX [Shigella flexneri 2a str. 2457T], gi\|30043809\|gb\|...	367.0	[0..1]	[426..1]
gi\|37528399, gi\|... - gi\|37528399\|ref\|NP_931744.1\| putative GTPase HflX [Photorhabdus luminescens subsp. laumondii TTO1], ...	365.0	[0..1]	[426..1]

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Predicted Domain #1

Region A:
Residues: [1-426]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFDRYDAGEQ AVLVHIYFTQ DKDMEDLQEF ESLVSSAGVE ALQVITGSRK APHPKYFVGE  60
   61 GKAVEIAEAV KATGASVVLF DHALSPAQER NLERLCECRV IDRTGLILDI FAQRARTHEG 120
  121 KLQVELAQLR HLATRLVRGW THLERQKGGI GLRGPGETQL ETDRRLLRNR IVQIQSRLER 180
  181 VEKQREQGRQ SRIKADVPTV SLVGYTNAGK STLFNRITEA RVYAADQLFA TLDPTLRRID 240
  241 VADVGETVLA DTVGFIRHLP HDLVAAFKAT LQETRQATLL LHVIDAADVR VQENIEAVNT 300
  301 VLEEIDAHEI PTLLVMNKID MLEDFEPRID RDEENKPNRV WLSAQTGAGI PQLFQALTER 360
  361 LSGEVAQHTL RLPPQEGRLR SRFYQLQAIE KEWMEEDGSV SLQVRMPIVD WRRLCKQEPA 420
  421 LIDYLI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.69897
Match:	1xzpA
Description:	Structure of the GTP-binding protein TrmE from Thermotoga maritima
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.36550713198424	bayes_pls_golite062009
catalytic activity	0.234613562021476	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.166100211611062	bayes_pls_golite062009
pyrophosphatase activity	0.159702441149605	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.149170905385965	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.147838751017739	bayes_pls_golite062009
hydrolase activity	0.0436758932827116	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: