YRC Public Data Repository - Protein Structure Prediction

Protein:	HEXR_ECOLI
Organism:	Escherichia coli
Length:	289 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEXR_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|215265138, gi... - gi\|215487066\|ref\|YP_002329497.1\| DNA-binding transcriptional regulator HexR [Escherichia coli O127:H... gi\|117624005, gi... - gi\|117624005\|ref\|YP_852918.1\| DNA-binding transcriptional regulator HexR [Escherichia coli APEC O1],... gi\|218558718, gi... - gi\|218558718\|ref\|YP_002391631.1\| DNA-binding transcriptional regulator HexR [Escherichia coli S88], ... gi\|226900564, gi... - gi\|237705807\|ref\|ZP_04536288.1\| hex regulon repressor [Escherichia sp. 3_2_53FAA], gi\|226900564\|gb\|E... gi\|218689791, gi... - gi\|218689791\|ref\|YP_002398003.1\| DNA-binding transcriptional regulator HexR [Escherichia coli ED1a],... gi\|227885719, gi... - gi\|227885719\|ref\|ZP_04003524.1\| DNA-binding transcriptional regulator HexR [Escherichia coli 83972],... gi\|91211078, gi\|... - gi\|91211078\|ref\|YP_541064.1\| DNA-binding transcriptional regulator HexR [Escherichia coli UTI89], gi... gi\|110343563, gi... - gi\|110641971\|ref\|YP_669701.1\| DNA-binding transcriptional regulator HexR [Escherichia coli 536], gi\|... gi\|75239726, gi\|... - gi\|75239726\|ref\|ZP_00723689.1\| COG1737: Transcriptional regulators [Escherichia coli F11], gi\|191172... gi\|26108522, gi\|... - gi\|26248119\|ref\|NP_754159.1\| DNA-binding transcriptional regulator HexR [Escherichia coli CFT073], g...	242.0	[0..1]	[289..1]
gi\|110615345, gi... - gi\|110805797\|ref\|YP_689317.1\| DNA-binding transcriptional regulator HexR [Shigella flexneri 5 str. 8...	241.0	[0..1]	[289..1]
gi\|168752106, gi... - gi\|188013985\|gb\|EDU52107.1\| transcriptional regulator, rpiR family [Escherichia coli O157:H7 str. EC... gi\|189367333, gi... - gi\|189367333\|gb\|EDU85749.1\| transcriptional regulator, rpiR family [Escherichia coli O157:H7 str. EC... gi\|168770836, gi... - gi\|189360281\|gb\|EDU78700.1\| transcriptional regulator, rpiR family [Escherichia coli O157:H7 str. EC... gi\|13362031, gi\|... - gi\|15831817\|ref\|NP_310590.1\| DNA-binding transcriptional regulator HexR [Escherichia coli O157:H7 st... gi\|209400498, gi... - gi\|209400498\|ref\|YP_002270936.1\| transcriptional regulator, rpiR family [Escherichia coli O157:H7 st... gi\|209919220, gi... - gi\|209919220\|ref\|YP_002293304.1\| DNA-binding transcriptional regulator HexR [Escherichia coli SE11],... gi\|217317961, gi... - gi\|217328614\|ref\|ZP_03444695.1\| transcriptional regulator, rpiR family [Escherichia coli O157:H7 str... gi\|218554427, gi... - gi\|218554427\|ref\|YP_002387340.1\| DNA-binding transcriptional regulator HexR [Escherichia coli IAI1],... gi\|218369561, gi... - gi\|218699575\|ref\|YP_002407204.1\| DNA-binding transcriptional regulator HexR [Escherichia coli IAI39]... gi\|218705354, gi... - gi\|218705354\|ref\|YP_002412873.1\| DNA-binding transcriptional regulator HexR [Escherichia coli UMN026... gi\|168777754, gi... - gi\|187767075\|gb\|EDU30919.1\| transcriptional regulator, rpiR family [Escherichia coli O157:H7 str. EC... gi\|168783154, gi... - gi\|188999484\|gb\|EDU68470.1\| transcriptional regulator, rpiR family [Escherichia coli O157:H7 str. EC... gi\|189372014, gi... - gi\|189372014\|gb\|EDU90430.1\| transcriptional regulator, rpiR family [Escherichia coli O157:H7 str. EC... gi\|189375634, gi... - gi\|189375634\|gb\|EDU94050.1\| transcriptional regulator, rpiR family [Escherichia coli O157:H7 str. EC... gi\|170683767, gi... - gi\|170683767\|ref\|YP_001743391.1\| RpiR family transcriptional regulator [Escherichia coli SMS-3-5], g... gi\|195939755 - gi\|195939755\|ref\|ZP_03085137.1\| DNA-binding transcriptional regulator HexR [Escherichia coli O157:H7... gi\|208810603, gi... - gi\|208810603\|ref\|ZP_03252479.1\| transcriptional regulator, rpiR family [Escherichia coli O157:H7 str... gi\|208731101, gi... - gi\|208816758\|ref\|ZP_03257878.1\| transcriptional regulator, rpiR family [Escherichia coli O157:H7 str... gi\|193069856, gi... - gi\|75235343\|ref\|ZP_00719569.1\| COG1737: Transcriptional regulators [Escherichia coli E110019], gi\|19... gi\|191168506, gi... - gi\|75228293\|ref\|ZP_00714945.1\| COG1737: Transcriptional regulators [Escherichia coli B7A], gi\|191168... gi\|24113203, gi\|... - gi\|24113203\|ref\|NP_707713.1\| DNA-binding transcriptional regulator HexR [Shigella flexneri 2a str. 3... gi\|209767548, gi... - pir\|\|G85797 hypothetical protein yebK [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|254592877, gi... - gi\|254793477\|ref\|YP_003078314.1\| predicted DNA-binding transcriptional regulator [Escherichia coli O... gi\|12515909, gi\|... - gi\|15802266\|ref\|NP_288290.1\| DNA-binding transcriptional regulator HexR [Escherichia coli O157:H7 ED... gi\|13362031, gi\|... - gi\|15831817\|ref\|NP_310590.1\| hypothetical protein ECs2563 [Escherichia coli O157:H7], gi\|13362031\|db...	241.0	[0..1]	[289..1]
gi\|74311824, gi\|... - gi\|74311824\|ref\|YP_310243.1\| DNA-binding transcriptional regulator HexR [Shigella sonnei Ss046], gi\|...	241.0	[0..1]	[289..1]
gi\|157155435, gi... - gi\|75190882\|ref\|ZP_00704149.1\| COG1737: Transcriptional regulators [Escherichia coli E24377A], gi\|15...	240.0	[0..1]	[289..1]
gi\|76591026, gi\|... - gi\|76793708\|ref\|ZP_00776191.1\| Helix-turn-helix protein RpiR:Sugar isomerase (SIS) [Pseudoalteromona...	236.0	[0..1]	[281..1]
gi\|75175691 - gi\|75175691\|ref\|ZP_00695897.1\| COG1737: Transcriptional regulators [Shigella boydii BS512]	235.0	[0..3]	[289..1]
gi\|114547285, gi... - gi\|114772096\|ref\|ZP_01449479.1\| putative transcriptional regulator [alpha proteobacterium HTCC2255],... gi\|114772096 - gi\|114772096\|ref\|ZP_01449479.1\| putative transcriptional regulator [alpha proteobacterium HTCC2255] gi\|221134213 - gi\|221134213\|ref\|ZP_03560518.1\| DNA-binding transcriptional regulator HexR [Glaciecola sp. HTCC2999]	234.0	[0..1]	[281..1]
gi\|108811705, gi... - gi\|108811705\|ref\|YP_647472.1\| hex regulon repressor [Yersinia pestis Nepal516], gi\|108775353\|gb\|ABG1... gi\|108807444, gi... - gi\|108807444\|ref\|YP_651360.1\| hex regulon repressor [Yersinia pestis Antiqua], gi\|108779357\|gb\|ABG13... gi\|145598352, gi... - gi\|145598352\|ref\|YP_001162428.1\| DNA-binding transcriptional regulator HexR [Yersinia pestis Pestoid... gi\|22126131, gi\|... - gi\|22126131\|ref\|NP_669554.1\| hypothetical protein y2245 [Yersinia pestis KIM], gi\|21959091\|gb\|AAM858... gi\|45441710, gi\|... - gi\|45441710\|ref\|NP_993249.1\| Transcriptional regulators [Yersinia pestis biovar Microtus str. 91001]...	234.0	[0..1]	[287..53]
gi\|204320011, gi... - gi\|204930967\|ref\|ZP_03221793.1\| HTH-type transcriptional regulator HexR [Salmonella enterica subsp. ... gi\|197250084, gi... - gi\|197250084\|ref\|YP_002146136.1\| HTH-type transcriptional regulator HexR [Salmonella enterica subsp.... gi\|238912053 - gi\|238912053\|ref\|ZP_04655890.1\| DNA-binding transcriptional regulator HexR [Salmonella enterica subs... gi\|194736565, gi... - gi\|194736565\|ref\|YP_002114922.1\| HTH-type transcriptional regulator HexR [Salmonella enterica subsp.... gi\|194455481, gi... - gi\|194469117\|ref\|ZP_03075101.1\| HTH-type transcriptional regulator HexR [Salmonella enterica subsp. ... gi\|25303537, gi\|... - gi\|25303537\|pir\|\|AC0742 probable hex-regulon repressor STY2095 [imported] - Salmonella enterica subs... gi\|29137098, gi\|... - gi\|29141471\|ref\|NP_804813.1\| DNA-binding transcriptional regulator HexR [Salmonella enterica subsp. ... gi\|214002659 - gi\|214002659\|ref\|ZP_03413394.1\| DNA-binding transcriptional regulator HexR [Salmonella enterica subs... gi\|213854140 - gi\|213854140\|ref\|ZP_03382672.1\| DNA-binding transcriptional regulator HexR [Salmonella enterica subs... gi\|213426412 - gi\|213426412\|ref\|ZP_03359162.1\| DNA-binding transcriptional regulator HexR [Salmonella enterica subs... gi\|205339514, gi... - gi\|205339514\|gb\|EDZ26278.1\| HTH-type transcriptional regulator HexR [Salmonella enterica subsp. ente... gi\|197288657, gi... - gi\|197288657\|gb\|EDY28032.1\| HTH-type transcriptional regulator HexR (Hex regulon repressor) [Salmone... gi\|16760837 - gi\|16760837\|ref\|NP_456454.1\| DNA-binding transcriptional regulator HexR [Salmonella enterica subsp. ... gi\|168233705, gi... - gi\|205332250\|gb\|EDZ19014.1\| HTH-type transcriptional regulator HexR [Salmonella enterica subsp. ente... gi\|194449540, gi... - gi\|194449540\|ref\|YP_002045940.1\| DNA-binding transcriptional regulator HexR [Salmonella enterica sub... gi\|194401157, gi... - gi\|194442494\|ref\|YP_002041152.1\| HTH-type transcriptional regulator HexR [Salmonella enterica subsp.... gi\|168820707, gi... - gi\|205342680\|gb\|EDZ29444.1\| HTH-type transcriptional regulator HexR [Salmonella enterica subsp. ente... gi\|168462584, gi... - gi\|195634465\|gb\|EDX52817.1\| HTH-type transcriptional regulator HexR [Salmonella enterica subsp. ente...	233.0	[0..1]	[289..1]

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Predicted Domain #1

Region A:
Residues: [1-289]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMLEKIQSQ LEHLSKSERK VAEVILASPD NAIHSSIAAM ALEANVSEPT VNRFCRSMDT  60
   61 RGFPDFKLHL AQSLANGTPY VNRNVNEDDS VESYTGKIFE SAMATLDHVR HSLDKSAINR 120
  121 AVDLLTQAKK IAFFGLGSSA AVAHDAMNKF FRFNVPVVYS DDIVLQRMSC MNCSDGDVVV 180
  181 LISHTGRTKN LVELAQLARE NDAMVIALTS AGTPLAREAT LAITLDVPED TDIYMPMVSR 240
  241 LAQLTVIDVL ATGFTLRRGA KFRDNLKRVK EALKESRFDK QLLNLSDDR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.69897
Match:	1jxaA
Description:	"Isomerase domain" of glucosamine 6-phosphate synthase (GLMS); Glucosamine 6-phosphate synthase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.5278037255884	bayes_pls_golite062009
binding	0.570536202654476	bayes_pls_golite062009
nucleic acid binding	0.447313798079347	bayes_pls_golite062009
peptidase activity	0.138118628047683	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: