YRC Public Data Repository - Protein Structure Prediction

Protein:	GUDX_ECOLI
Organism:	Escherichia coli
Length:	446 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GUDX_ECOLI.

Description	E-value	Query Range	Subject Range
ENO_BACCN - Enolase OS=Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) GN=eno PE=3 SV...	361.0	[0..1]	[394..13]
gi\|134300819, gi... - gi\|88946884\|ref\|ZP_01149948.1\| Enolase [Desulfotomaculum reducens MI-1], gi\|88923629\|gb\|EAR42652.1\| ...	361.0	[0..1]	[386..13]
ENO_GEOKA - Enolase OS=Geobacillus kaustophilus GN=eno PE=3 SV=1 gi\|220708629, gi... - gi\|221087380\|ref\|ZP_03556918.1\| Phosphopyruvate hydratase [Geobacillus sp. Y412MC61], gi\|220708629\|g... ENO_GEOKA - Enolase OS=Geobacillus kaustophilus (strain HTA426) GN=eno PE=3 SV=1 gi\|229500702, gi... - gi\|229500702\|ref\|ZP_04394349.1\| Phosphopyruvate hydratase [Geobacillus sp. Y412MC52], gi\|229328402\|g...	359.0	[0..1]	[390..13]
gi\|460259 - gi\|460259\|gb\|AAA21681.1\| enolase [Bacillus subtilis subsp. subtilis str. 168] gi\|460259\|gb\|AAA... - enolase	359.0	[0..1]	[384..13]
ENO_BACSU - Enolase OS=Bacillus subtilis (strain 168) GN=eno PE=1 SV=4 gi\|221315667 - gi\|221315667\|ref\|ZP_03597472.1\| phosphopyruvate hydratase [Bacillus subtilis subsp. subtilis str. NC... gi\|221320583 - gi\|221320583\|ref\|ZP_03601877.1\| phosphopyruvate hydratase [Bacillus subtilis subsp. subtilis str. JH... gi\|221324867 - gi\|221324867\|ref\|ZP_03606161.1\| phosphopyruvate hydratase [Bacillus subtilis subsp. subtilis str. SM... ENO_BACSU - Enolase OS=Bacillus subtilis GN=eno PE=1 SV=4	359.0	[0..1]	[384..13]
gi\|228728574, gi... - gi\|229032747\|ref\|ZP_04188707.1\| Enolase [Bacillus cereus AH1271], gi\|228728574\|gb\|EEL79590.1\| Enolas... gi\|229175798, gi... - gi\|229175798\|ref\|ZP_04303304.1\| Enolase [Bacillus cereus MM3], gi\|228607749\|gb\|EEK65065.1\| Enolase [... gi\|229169836, gi... - gi\|229169836\|ref\|ZP_04297532.1\| Enolase [Bacillus cereus AH621], gi\|228613550\|gb\|EEK70679.1\| Enolase... ENO_BACWK - Enolase OS=Bacillus weihenstephanensis (strain KBAB4) GN=eno PE=3 SV=1	359.0	[0..1]	[394..13]
ENO_BACCZ - Enolase OS=Bacillus cereus (strain ZK / E33L) GN=eno PE=3 SV=1 gi\|228658976, gi... - gi\|229124636\|ref\|ZP_04253821.1\| Enolase [Bacillus cereus 95/8201], gi\|228658976\|gb\|EEL14631.1\| Enola...	358.0	[0..1]	[394..13]
gi\|47567341, gi\|... - gi\|47567341\|ref\|ZP_00238054.1\| enolase [Bacillus cereus G9241], gi\|47555962\|gb\|EAL14300.1\| enolase [...	358.0	[0..1]	[394..13]
gi\|170707808, gi... - gi\|170707808\|ref\|ZP_02898259.1\| enolase [Bacillus anthracis str. A0389], gi\|170127365\|gb\|EDS96241.1\|... gi\|177652927, gi... - gi\|177652927\|ref\|ZP_02935254.1\| enolase [Bacillus anthracis str. A0174], gi\|172081702\|gb\|EDT66772.1\|... gi\|190561158, gi... - gi\|190567742\|ref\|ZP_03020654.1\| enolase [Bacillus anthracis Tsiankovskii-I], gi\|190561158\|gb\|EDV1513... gi\|195994170, gi... - gi\|196032741\|ref\|ZP_03100154.1\| enolase [Bacillus cereus W], gi\|195994170\|gb\|EDX58125.1\| enolase [Ba... ENO_BACAN - Enolase OS=Bacillus anthracis GN=eno PE=3 SV=1 gi\|196029748, gi... - gi\|196039588\|ref\|ZP_03106893.1\| enolase [Bacillus cereus NVH0597-99], gi\|196029748\|gb\|EDX68350.1\| en... ENO_BACHK - Enolase OS=Bacillus thuringiensis subsp. konkukian GN=eno PE=3 SV=1 gi\|196045659, gi... - gi\|196045659\|ref\|ZP_03112889.1\| enolase [Bacillus cereus 03BB108], gi\|196023490\|gb\|EDX62167.1\| enola... ENO_BACC0 - Enolase OS=Bacillus cereus (strain AH820) GN=eno PE=3 SV=1 ENO_BACHK - Enolase OS=Bacillus thuringiensis subsp. konkukian (strain 97-27) GN=eno PE=3 SV=1 gi\|49187971, gi\|... - gi\|49187971\|ref\|YP_031224.1\| phosphopyruvate hydratase [Bacillus anthracis str. Sterne], gi\|49181898... gi\|164714325, gi... - gi\|165870002\|ref\|ZP_02214659.1\| enolase [Bacillus anthracis str. A0488], gi\|164714325\|gb\|EDR19845.1\|... gi\|167529335, gi... - gi\|167635292\|ref\|ZP_02393607.1\| enolase [Bacillus anthracis str. A0442], gi\|167529335\|gb\|EDR92087.1\|... gi\|167510049, gi... - gi\|167641999\|ref\|ZP_02400232.1\| enolase [Bacillus anthracis str. A0193], gi\|167510049\|gb\|EDR85462.1\|... ENO_BACC3 - Enolase OS=Bacillus cereus (strain 03BB102) GN=eno PE=3 SV=1 gi\|170687942, gi... - gi\|170687942\|ref\|ZP_02879155.1\| enolase [Bacillus anthracis str. A0465], gi\|170668051\|gb\|EDT18801.1\|... ENO_BACAC - Enolase OS=Bacillus anthracis (strain CDC 684 / NRRL 3495) GN=eno PE=3 SV=1 gi\|228841975, gi... - gi\|228917738\|ref\|ZP_04081279.1\| Enolase [Bacillus thuringiensis serovar pulsiensis BGSC 4CC1], gi\|22... gi\|228930134, gi... - gi\|228930134\|ref\|ZP_04093144.1\| Enolase [Bacillus thuringiensis serovar pondicheriensis BGSC 4BA1], ... gi\|228936419, gi... - gi\|228936419\|ref\|ZP_04099217.1\| Enolase [Bacillus thuringiensis serovar andalousiensis BGSC 4AW1], g... gi\|228948838, gi... - gi\|228948838\|ref\|ZP_04111113.1\| Enolase [Bacillus thuringiensis serovar monterrey BGSC 4AJ1], gi\|228... gi\|47505822, gi\|... - gi\|47530674\|ref\|YP_022023.1\| phosphopyruvate hydratase [Bacillus anthracis str. 'Ames Ancestor'], gi... gi\|228771339, gi... - gi\|228988358\|ref\|ZP_04148450.1\| Enolase [Bacillus thuringiensis serovar tochigiensis BGSC 4Y1], gi\|2... gi\|30265161, gi\|... - gi\|30265161\|ref\|NP_847538.1\| phosphopyruvate hydratase [Bacillus anthracis str. Ames], gi\|30259838\|g... gi\|229020340, gi... - gi\|229020340\|ref\|ZP_04177106.1\| Enolase [Bacillus cereus AH1273], gi\|228740976\|gb\|EEL91208.1\| Enolas... gi\|21397598, gi\|... - gi\|65317107\|ref\|ZP_00390066.1\| COG0148: Enolase [Bacillus anthracis str. A2012], ref\|NP_653583.1\| en... gi\|228734748, gi... - gi\|229026571\|ref\|ZP_04182920.1\| Enolase [Bacillus cereus AH1272], gi\|228734748\|gb\|EEL85393.1\| Enolas... gi\|229094221, gi... - gi\|229094221\|ref\|ZP_04225300.1\| Enolase [Bacillus cereus Rock3-42], gi\|228689213\|gb\|EEL43035.1\| Enol... gi\|229158699, gi... - gi\|229158699\|ref\|ZP_04286757.1\| Enolase [Bacillus cereus ATCC 4342], gi\|228624683\|gb\|EEK81452.1\| Eno... gi\|228619455, gi... - gi\|229164072\|ref\|ZP_04292009.1\| Enolase [Bacillus cereus R309803], gi\|228619455\|gb\|EEK76344.1\| Enola... gi\|229187344, gi... - gi\|229187344\|ref\|ZP_04314487.1\| Enolase [Bacillus cereus BGSC 6E1], gi\|228596048\|gb\|EEK53725.1\| Enol... ENO_BACAA - Enolase OS=Bacillus anthracis (strain A0248) GN=eno PE=3 SV=1 gi\|254686438 - gi\|254686438\|ref\|ZP_05150297.1\| phosphopyruvate hydratase [Bacillus anthracis str. CNEVA-9066] gi\|254724437 - gi\|254724437\|ref\|ZP_05186221.1\| phosphopyruvate hydratase [Bacillus anthracis str. A1055] gi\|254735644 - gi\|254735644\|ref\|ZP_05193351.1\| phosphopyruvate hydratase [Bacillus anthracis str. Western North Ame... gi\|254744269 - gi\|254744269\|ref\|ZP_05201949.1\| phosphopyruvate hydratase [Bacillus anthracis str. Kruger B] ENO_BACAH - Enolase OS=Bacillus thuringiensis (strain Al Hakam) GN=eno PE=3 SV=1 gi\|254755567 - gi\|254755567\|ref\|ZP_05207600.1\| phosphopyruvate hydratase [Bacillus anthracis str. Vollum] gi\|254757022 - gi\|254757022\|ref\|ZP_05209050.1\| phosphopyruvate hydratase [Bacillus anthracis str. Australia 94]	358.0	[0..1]	[394..13]
gi\|89098799, gi\|... - gi\|89098799\|ref\|ZP_01171680.1\| enolase [Bacillus sp. NRRL B-14911], gi\|89086475\|gb\|EAR65595.1\| enola...	358.0	[0..1]	[390..13]

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Predicted Domain #1

Region A:
Residues: [1-446]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATQSSPVIT DMKVIPVAGH DSMLLNIGGA HNAYFTRNIV VLTDNAGHTG IGEAPGGDVI  60
   61 YQTLVDAIPM VLGQEVARLN KVVQQVHKGN QAADFDTFGK GAWTFELRVN AVAALEAALL 120
  121 DLLGKALNVP VCELLGPGKQ REAITVLGYL FYIGDRTKTD LPYVENTPGN HEWYQLRHQK 180
  181 AMNSEAVVRL AEASQDRYGF KDFKLKGGVL PGEQEIDTVR ALKKRFPDAR ITVDPNGAWL 240
  241 LDEAISLCKG LNDVLTYAED PCGAEQGFSG REVMAEFRRA TGLPVATNMI ATNWREMGHA 300
  301 VMLNAVDIPL ADPHFWTLSG AVRVAQLCDD WGLTWGCHSN NHFDISLAMF THVGAAAPGN 360
  361 PTAIDTHWIW QEGDCRLTQN PLEIKNGKIA VPDAPGLGVE LDWEQVQKAH EAYKRLPGGA 420
  421 RNDAGPMQYL IPGWTFDRKR PVFGRH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	94.0
Match:	1ec7A
Description:	D-glucarate dehydratase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphopyruvate hydratase activity	2.09734347546664	bayes_pls_golite062009
lyase activity	0.953241510600178	bayes_pls_golite062009
carbon-oxygen lyase activity	0.908937887773213	bayes_pls_golite062009
hydro-lyase activity	0.874016693867333	bayes_pls_golite062009
glucarate dehydratase activity	0.760146153620695	bayes_pls_golite062009
catalytic activity	0.534516847146079	bayes_pls_golite062009
racemase and epimerase activity, acting on hydroxy acids and derivatives	0.207225670131667	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: