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View Structure Prediction Details

Protein: grk-PA
Organism: Drosophila melanogaster
Length: 295 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for grk-PA.

Description E-value Query
Range
Subject
Range
gi|542578, gi|80... - gi|8096687|gb|AAF72000.1|AF223394_1 gurken [Drosophila melanogaster], pir||A48844 TGF alpha-like pro...
199.0 [0..2] [295..1]
gi|73979548 - gi|73979548|ref|XP_532835.2| PREDICTED: similar to FAT tumor suppressor 1 precursor [Canis familiari...
160.0 [0..45] [282..3958]
gi|66346693 - gi|66346693|ref|NP_005236.2| FAT tumor suppressor 1 precursor [Homo sapiens]
158.0 [0..45] [282..3955]
gi|13929168, gi|... - gi|4426629|gb|AAD20459.1| protocadherin [Rattus norvegicus], gi|13929168|ref|NP_114007.1| FAT tumor ...
152.0 [0..100] [283..4009]
gi|27463074, gi|... - gi|47085727|ref|NP_998132.1| FAT tumor suppressor homolog 1 [Danio rerio], gi|27463074|gb|AAO15696.1...
151.0 [0..63] [267..3980]
gi|124486855, gi... - gi|82917259|ref|XP_890829.1| PREDICTED: fat tumor suppressor homolog isoform 1 [Mus musculus], gi|82...
147.0 [0..100] [282..3993]
gi|115893463, gi... - gi|115930648|ref|XP_001178590.1| PREDICTED: similar to fibropellin Ib [Strongylocentrotus purpuratus...
138.0 [0..68] [295..1668]
gi|12055236 - gi|12055236|emb|CAC20782.1| fibrosurfin [Paracentrotus lividus]
133.0 [0..68] [295..2402]

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Predicted Domain #1
Region A:
Residues: [1-295]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMQIPFTRIF KVIFVLSTIV AVTDCCSSRI LLLREHTLKI VQHQHSHMHE HAHELQQQIQ  60
   61 ETAVELLNRL ELQRKQLEAS AQEEADQLHP DTDPNPDSGG QLPNADDSIA ADPEQDGIIL 120
  121 GSSTDTWLAS ESSTPITDSE TVTTPETVTH TGEPPPDPSS SSTPDSTTPS PNDKETEIQM 180
  181 LPCSEAYNTS FCLNGGHCFQ HPMVNNTVFH SCLCVNDYDG ERCAYKSWNG DYIYSPPTAQ 240
  241 RKVRMAHIVF SFPVLLMLSS LYVLFAAVFM LRNVPDYRRK QQQLHLHKQR FFVRC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.60755835611133 bayes_pls_golite062009
epidermal growth factor receptor binding 4.4860322783685 bayes_pls_golite062009
growth factor activity 4.38305031783896 bayes_pls_golite062009
binding 2.54996368217395 bayes_pls_golite062009
heparin binding 2.49012176521764 bayes_pls_golite062009
glycosaminoglycan binding 2.44185509650703 bayes_pls_golite062009
polysaccharide binding 2.16901652361989 bayes_pls_golite062009
protein binding 1.97546801934296 bayes_pls_golite062009
pattern binding 1.92168039086846 bayes_pls_golite062009
ErbB-2 class receptor binding 1.42853255302174 bayes_pls_golite062009
ErbB-3 class receptor binding 1.17748426017837 bayes_pls_golite062009
transcription regulator activity 0.724489340907325 bayes_pls_golite062009
transcription factor binding 0.62178723762474 bayes_pls_golite062009
transcription cofactor activity 0.50737750327034 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle