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View Structure Prediction Details

Protein: gi|151943780
Organism: Saccharomyces cerevisiae YJM789
Length: 841 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|151943780.

Description E-value Query
Range		 Subject
Range
gi|151943780 - gi|151943780|gb|EDN62080.1| AdoMet-dependent rRNA methyltransferase [Saccharomyces cerevisiae YJM789...
SPB1_YEAST - 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 20450...
SPB1 - AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation;...
 0.0 [1..841] [1..841]
gi|10954014 - gi|10954014|gb|AAG25705.1| SPB1-like protein [Saccharomyces servazzii]
 0.0 [1..841] [1..841]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [1..724] [1..724]
SPB1_SCHPO - AdoMet-dependent rRNA methyltransferase spb1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) ...
spb1 - rRNA methyltransferase Spb1
 0.0 [1..836] [1..799]
gi|18028291 - gi|18028291|gb|AAL56015.1|AF327355_1 hypothetical protein SB92 [Homo sapiens]
 4.0E-98 [1..829] [1..834]
SPB1_MOUSE - pre-rRNA processing protein FTSJ3 OS=Mus musculus GN=Ftsj3 PE=1 SV=1
 6.0E-93 [1..829] [1..825]
SPB1_NEUCR - AdoMet-dependent rRNA methyltransferase spb1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / ...
SPB1_NEUCR - AdoMet-dependent rRNA methyltransferase spb-1 OS=Neurospora crassa GN=spb-1 PE=3 SV=2
 2.0E-88 [5..837] [4..831]

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Predicted Domain #1
Region A:
Residues: [1-204] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKTQKKNSK GRLDRYYYLA KEKGYRARSS FKIIQINEKY GHFLEKSKVV IDLCAAPGSW  60
   61 CQVASKLCPV NSLIIGVDIV PMKPMPNVIT FQSDITTEDC RSKLRGYMKT WKADTVLHDG 120
  121 APNVGLGWVQ DAFTQSQLTL QALKLAVENL VVNGTFVTKI FRSKDYNKLI WVFQQLFEKV 180
  181 EATKPPASRN VSAEIFVVCK GFKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 226.679424
Match: 1eizA_
Description: RNA methyltransferase FtsJ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
rRNA (guanine) methyltransferase activity 4.21285117944777 bayes_pls_golite062009
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
rRNA methyltransferase activity 4.09362182773099 bayes_pls_golite062009
N-methyltransferase activity 4.07806017452628 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
protein methyltransferase activity 3.92746815303714 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.39429041855776 bayes_pls_golite062009
RNA methyltransferase activity 3.07428840534971 bayes_pls_golite062009
histone methyltransferase activity 2.99461585647365 bayes_pls_golite062009
DNA-methyltransferase activity 2.43145108778901 bayes_pls_golite062009
protein-arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
transferase activity 2.22303238506686 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.04296107639729 bayes_pls_golite062009
RNA binding 1.99752836873461 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 1.83964463328968 bayes_pls_golite062009
tRNA methyltransferase activity 1.76571145896453 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 1.75675289134467 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 1.66871163498737 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 1.1103522853299 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
rRNA (uridine-2'-O-)-methyltransferase activity 0.90544396691236 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 0.89325812193225 bayes_pls_golite062009
DNA binding 0.86027591375666 bayes_pls_golite062009
rRNA (uridine) methyltransferase activity 0.742142092552002 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 0.703178429468566 bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity 0.672282175551951 bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity 0.672282175551951 bayes_pls_golite062009
nucleic acid binding 0.616949327277483 bayes_pls_golite062009
binding 0.383237930789959 bayes_pls_golite062009
O-methyltransferase activity 0.250946859465502 bayes_pls_golite062009
rRNA (guanine-N1-)-methyltransferase activity 0.234572322347698 bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity 0.1772047818218 bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity 0.1772047818218 bayes_pls_golite062009
mRNA binding 0.0540207721800283 bayes_pls_golite062009
snoRNA binding 0.00848192089639488 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [205-532] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKRLDPRLLD PKEVFEELPD GQQNMESKIY NPEKKVRKRQ GYEEGDNLLY HETSILDFVR  60
   61 TEDPISMLGE MNKFTIDEND HEWKILKKLK QTTDEFRSCI EDLKVLGKKD FKMILRWRKI 120
  121 AREILGIEVK DDAKTEIEVV PLTEEEQIEK DLQGLQEKQR LNVKRERRRK NEMKQKELQR 180
  181 MQMNMITPTD IGIEAASLGK ESLFNLKTAE KTGILNDLAK GKKRMIFTDD ELAKDNDIYI 240
  241 DENIMIKDKD SAADADDLES ELNAMYSDYK TRRSERDAKF RAKQARGGDN EEEWTGFNEG 300
  301 SLEKKEEEGK DYIEDNDDEG VEGDSDDD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.0
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [533-629] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAITNLISKL KGQEGDHKLS SKARMIFNDP IFNNVEPDLP VNTVNDGIMS SESVGDISKL  60
   61 NKKRKHEEMH QKQDEADSSD ESSSDDSDFE IVANDNA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [630-713] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEEFDSDYDS EEEKNQTKKE KHSRDIDIAT VEAMTLAHQL ALGQKNKHDL VDEGFNRYTF  60
   61 RDTENLPDWF LEDEKEHSKI NKPI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [714-841] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKEAAMAIKE KIKAMNARPI KKVAEAKARK RMRAVARLEK IKKKAGLIND DSDKTEKDKA  60
   61 EEISRLMRKV TKKPKTKPKV TLVVASGRNK GLAGRPKGVK GKYKMVDGVM KNEQRALRRI 120
  121 AKKHHKKK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.299 0.622 processing of 27S pre-rRNA c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.280 0.163 processing of 27S pre-rRNA a.1.1 Globin-like
View Download 0.227 0.017 processing of 27S pre-rRNA c.46.1 Rhodanese/Cell cycle control phosphatase
View Download 0.427 0.011 processing of 27S pre-rRNA a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.246 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.224 N/A N/A c.23.1 CheY-like
View Download 0.205 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle