YRC Public Data Repository - Protein Structure Prediction

Protein:	GLTB_ECOLI
Organism:	Escherichia coli
Length:	1517 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GLTB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|75209655 - gi\|75209655\|ref\|ZP_00709867.1\| COG0069: Glutamate synthase domain 2 [Escherichia coli B171]	1829.0	[0..1]	[1517..6]
gi\|75256588 - gi\|75256588\|ref\|ZP_00728218.1\| COG0069: Glutamate synthase domain 2 [Escherichia coli E22] gi\|75188018 - gi\|75188018\|ref\|ZP_00701285.1\| COG0069: Glutamate synthase domain 2 [Escherichia coli E24377A]	1827.0	[0..1]	[1517..6]
gi\|91212638, gi\|... - gi\|91212638\|ref\|YP_542624.1\| glutamate synthase [NADPH] large chain precursor [Escherichia coli UTI8... gi\|115514628, gi... - gi\|117625504\|ref\|YP_858827.1\| glutamate synthase subunit alpha [Escherichia coli APEC O1], gi\|115514...	1827.0	[0..1]	[1517..6]
gi\|75511885 - gi\|75511885\|ref\|ZP_00734497.1\| COG0069: Glutamate synthase domain 2 [Escherichia coli 53638] gi\|75197161 - gi\|75197161\|ref\|ZP_00707231.1\| COG0069: Glutamate synthase domain 2 [Escherichia coli HS]	1827.0	[0..1]	[1517..6]
gi\|81246962, gi\|... - gi\|82545551\|ref\|YP_409498.1\| glutamate synthase subunit alpha [Shigella boydii Sb227], gi\|81246962\|g...	1827.0	[0..1]	[1517..1]
gi\|83585410 - gi\|83585410\|ref\|ZP_00924056.1\| COG0069: Glutamate synthase domain 2 [Escherichia coli 101-1]	1827.0	[0..1]	[1517..6]
gi\|75236485 - gi\|75236485\|ref\|ZP_00720580.1\| COG0069: Glutamate synthase domain 2 [Escherichia coli F11]	1826.0	[0..1]	[1517..6]
gi\|25284753 - pir\|\|C91140 glutamate synthase large subunit [imported] - Escherichia coli (strain O157:H7, substrai... gi\|13363564, gi\|... - gi\|15833345\|ref\|NP_312118.1\| glutamate synthase large subunit [Escherichia coli O157:H7], gi\|1336356... gi\|13363564, gi\|... - gi\|15833345\|ref\|NP_312118.1\| glutamate synthase subunit alpha [Escherichia coli O157:H7 str. Sakai],...	1826.0	[0..1]	[1517..1]
gi\|30042808, gi\|... - gi\|30064549\|ref\|NP_838720.1\| glutamate synthase, large subunit [Shigella flexneri 2a str. 2457T], gi...	1826.0	[0..1]	[1517..6]
gi\|75176096 - gi\|75176096\|ref\|ZP_00696264.1\| COG0069: Glutamate synthase domain 2 [Shigella boydii BS512]	1826.0	[0..1]	[1517..6]

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Predicted Domain #1

Region A:
Residues: [1-1517]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRKPRRHAL SVPVRSGSEV GFPQSLGEVH DMLYDKSLER DNCGFGLIAH IEGEPSHKVV  60
   61 RTAIHALARM QHRGAILADG KTGDGCGLLL QKPDRFFRIV AQERGWRLAK NYAVGMLFLN 120
  121 KDPELAAAAR RIVEEELQRE TLSIVGWRDV PTNEGVLGEI ALSSLPRIEQ IFVNAPAGWR 180
  181 PRDMERRLFI ARRRIEKRLE ADKDFYVCSL SNLVNIYKGL CMPTDLPRFY LDLADLRLES 240
  241 AICLFHQRFS TNTVPRWPLA QPFRYLAHNG EINTITGNRQ WARARTYKFQ TPLIPDLHDA 300
  301 APFVNETGSD SSSMDNMLEL LLAGGMDIIR AMRLLVPPAW QNNPDMDPEL RAFFDFNSMH 360
  361 MEPWDGPAGI VMSDGRFAAC NLDRNGLRPA RYVITKDKLI TCASEVGIWD YQPDEVVEKG 420
  421 RVGPGELMVI DTRSGRILHS AETDDDLKSR HPYKEWMEKN VRRLVPFEDL PDEEVGSREL 480
  481 DDDTLASYQK QFNYSAEELD SVIRVLGENG QEAVGSMGDD TPFAVLSSQP RIIYDYFRQQ 540
  541 FAQVTNPPID PLREAHVMSL ATSIGREMNV FCEAEGQAHR LSFKSPILLY SDFKQLTTMK 600
  601 EEHYRADTLD ITFDVTKTTL EATVKELCDK AEKMVRSGTV LLVLSDRNIA KDRLPVPAPM 660
  661 AVGAIQTRLV DQSLRCDANI IVETASARDP HHFAVLLGFG ATAIYPYLAY ETLGRLVDTH 720
  721 AIAKDYRTVM LNYRNGINKG LYKIMSKMGI STIASYRCSK LFEAVGLHDD VVGLCFQGAV 780
  781 SRIGGASFED FQQDLLNLSK RAWLARKPIS QGGLLKYVHG GEYHAYNPDV VRTLQQAVQS 840
  841 GEYSDYQEYA KLVNERPATT LRDLLAITPG ENAVNIADVE PASELFKRFD TAAMSIGALS 900
  901 PEAHEALAEA MNSIGGNSNS GEGGEDPARY GTNKVSRIKQ VASGRFGVTP AYLVNADVIQ 960
  961 IKVAQGAKPG EGGQLPGDKV TPYIAKLRYS VPGVTLISPP PHHDIYSIED LAQLIFDLKQ1020
 1021 VNPKAMISVK LVSEPGVGTI ATGVAKAYAD LITIAGYDGG TGASPLSSVK YAGCPWELGL1080
 1081 VETQQALVAN GLRHKIRLQV DGGLKTGVDI IKAAILGAES FGFGTGPMVA LGCKYLRICH1140
 1141 LNNCATGVAT QDDKLRKNHY HGLPFKVTNY FEFIARETRE LMAQLGVTRL VDLIGRTDLL1200
 1201 KELDGFTAKQ QKLALSKLLE TAEPHPGKAL YCTENNPPFD NGLLNAQLLQ QAKPFVDERQ1260
 1261 SKTFWFDIRN TDRSVGASLS GYIAQTHGDQ GLAADPIKAY FNGTAGQSFG VWNAGGVELY1320
 1321 LTGDANDYVG KGMAGGLIAI RPPVGSAFRS HEASIIGNTC LYGATGGRLY AAGRAGERFG1380
 1381 VRNSGAITVV EGIGDNGCEY MTGGIVCILG KTGVNFGAGM TGGFAYVLDE SGDFRKRVNP1440
 1441 ELVEVLSVDA LAIHEEHLRG LITEHVQHTG SQRGEEILAN WSTFATKFAL VKPKSSDVKA1500
 1501 LLGHRSRSAA ELRVQAQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1llwA
Description:	Alpha subunit of glutamate synthase, C-terminal domain; Alpha subunit of glutamate synthase, central and FMN domains; Alpha subunit of glutamate synthase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glutamate synthase activity	10.2123323896554	bayes_pls_golite062009
glutamate synthase activity, NADH or NADPH as acceptor	9.64220719720108	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	8.40816887743017	bayes_pls_golite062009
glutamate synthase (NADPH) activity	7.71666213946687	bayes_pls_golite062009
oxidoreductase activity	2.15666801512485	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	0.330721070169443	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: