YRC Public Data Repository - Protein Structure Prediction

Protein:	FUCO_ECOLI
Organism:	Escherichia coli
Length:	383 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FUCO_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77995475, gi\|... - gi\|78043360\|ref\|YP_359772.1\| putative lactaldehyde reductase [Carboxydothermus hydrogenoformans Z-29...	419.0	[0..1]	[382..1]
gi\|98660195 - gi\|98660195\|dbj\|GAA02506.1\| unnamed protein product [Pelotomaculum thermopropionicum SI]	410.0	[0..2]	[382..46]
gi\|52307909, gi\|... - gi\|52425857\|ref\|YP_088994.1\| EutG protein [Mannheimia succiniciproducens MBEL55E], gi\|52307909\|gb\|AA...	407.0	[0..2]	[383..6]
gi\|90311944, gi\|... - gi\|90406902\|ref\|ZP_01215093.1\| putative alcohol dehydrogenase [Psychromonas sp. CNPT3], gi\|90311944\|...	401.0	[0..2]	[382..1]
gi\|254228886, gi... - gi\|75856694\|ref\|ZP_00764318.1\| COG1454: Alcohol dehydrogenase, class IV [Vibrio sp. Ex25], gi\|254228...	397.0	[0..2]	[382..1]
gi\|56178914, gi\|... - gi\|56459904\|ref\|YP_155185.1\| alcohol dehydrogenase [Idiomarina loihiensis L2TR], gi\|56178914\|gb\|AAV8...	395.0	[0..2]	[383..1]
gi\|114843983, gi... - gi\|167040564\|ref\|YP_001663549.1\| iron-containing alcohol dehydrogenase [Thermoanaerobacter sp. X514]... gi\|242230024, gi... - gi\|242258460\|ref\|ZP_04803261.1\| iron-containing alcohol dehydrogenase [Thermoanaerobacter sp. X513],...	394.0	[0..1]	[382..1]
gi\|110803754, gi... - gi\|110803754\|ref\|YP_697771.1\| alcohol dehydrogenase 2 [Clostridium perfringens SM101], gi\|110684255\|...	392.0	[0..2]	[382..1]
gi\|90437564, gi\|... - gi\|90581193\|ref\|ZP_01236991.1\| putative alcohol dehydrogenase [Vibrio angustum S14], gi\|90437564\|gb\|...	392.0	[0..2]	[382..1]
gi\|88917673, gi\|... - gi\|88935578\|ref\|ZP_01141208.1\| putative alcohol dehydrogenase [Geobacter uraniumreducens Rf4], gi\|88...	392.0	[0..2]	[382..6]

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Predicted Domain #1

Region A:
Residues: [1-383]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMANRMILNE TAWFGRGAVG ALTDEVKRRG YQKALIVTDK TLVQCGVVAK VTDKMDAAGL  60
   61 AWAIYDGVVP NPTITVVKEG LGVFQNSGAD YLIAIGGGSP QDTCKAIGII SNNPEFADVR 120
  121 SLEGLSPTNK PSVPILAIPT TAGTAAEVTI NYVITDEEKR RKFVCVDPHD IPQVAFIDAD 180
  181 MMDGMPPALK AATGVDALTH AIEGYITRGA WALTDALHIK AIEIIAGALR GSVAGDKDAG 240
  241 EEMALGQYVA GMGFSNVGLG LVHGMAHPLG AFYNTPHGVA NAILLPHVMR YNADFTGEKY 300
  301 RDIARVMGVK VEGMSLEEAR NAAVEAVFAL NRDVGIPPHL RDVGVRKEDI PALAQAALDD 360
  361 VCTGGNPREA TLEDIVELYH TAW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	105.0
Match:	1rrmA
Description:	Crystal Structure of Lactaldehyde reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydroxyacid-oxoacid transhydrogenase activity	8.51876704052427	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	4.00011629375661	bayes_pls_golite062009
oxidoreductase activity	3.07409531087588	bayes_pls_golite062009
alcohol dehydrogenase activity, metal ion-independent	3.05722501802075	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.83823088483915	bayes_pls_golite062009
catalytic activity	2.37357608468991	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2.10085302216488	bayes_pls_golite062009
binding	1.15096180564234	bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity	0.831155115586418	bayes_pls_golite062009
cation binding	0.319000821544479	bayes_pls_golite062009
metal ion binding	0.319000821544479	bayes_pls_golite062009
ion binding	0.313606245452103	bayes_pls_golite062009
protein binding	0.295023706645045	bayes_pls_golite062009
transition metal ion binding	0.259889634539407	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.0904828025133766	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: