YRC Public Data Repository - Protein Structure Prediction

Protein:	FRVX_ECOLI
Organism:	Escherichia coli
Length:	356 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRVX_ECOLI.

Description	E-value	Query Range	Subject Range
DAPE_IDILO - Succinyl-diaminopimelate desuccinylase OS=Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L... DAPE_IDILO - Succinyl-diaminopimelate desuccinylase OS=Idiomarina loihiensis GN=dapE PE=3 SV=1	264.0	[0..2]	[341..5]
gi\|85711706, gi\|... - gi\|85711706\|ref\|ZP_01042763.1\| succinyl-diaminopimelate desuccinylase [Idiomarina baltica OS145], gi...	264.0	[0..2]	[342..6]
gi\|55670846, gi\|... - gi\|55670848\|pdb\|1XFO\|D Chain D, Crystal Structure Of An Archaeal Aminopeptidase, gi\|55670847\|pdb\|1XF...	263.0	[0..1]	[346..11]
TET_PYRHO - Tetrahedral aminopeptidase OS=Pyrococcus horikoshii GN=frvX PE=1 SV=1 TET_PYRHO - Tetrahedral aminopeptidase OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBR...	263.0	[0..1]	[346..7]
gi\|14520851, gi\|... - gi\|5458068\|emb\|CAB49557.1\| endO 1,4-betaglucanase (cellulase M) (EGM) [Pyrococcus abyssi GE5], gi\|14... gi\|7435584, gi\|5... - pir\|\|D75105 aminopeptidase m42 PAB0437 [imported] - Pyrococcus abyssi (strain Orsay), gi\|5458068\|em...	263.0	[0..1]	[346..2]
gi\|57640716, gi\|... - gi\|57640716\|ref\|YP_183194.1\| deblocking aminopeptidase [Thermococcus kodakarensis KOD1], gi\|57159040...	262.0	[0..1]	[346..2]
gi\|18893685, gi\|... - gi\|18977919\|ref\|NP_579276.1\| endoglucanase [Pyrococcus furiosus DSM 3638], gi\|18893685\|gb\|AAL81671.1...	262.0	[0..1]	[346..2]
gi\|90309700, gi\|... - gi\|90409194\|ref\|ZP_01217307.1\| succinyl-diaminopimelate desuccinylase [Psychromonas sp. CNPT3], gi\|9...	261.0	[0..3]	[341..7]
gi\|75230420, gi\|... - gi\|75230420\|ref\|ZP_00716906.1\| COG1363: Cellulase M and related proteins [Escherichia coli B7A], gi\|... gi\|157079955, gi... - gi\|75188634\|ref\|ZP_00701901.1\| COG1363: Cellulase M and related proteins [Escherichia coli E24377A],... gi\|218556461, gi... - gi\|218556461\|ref\|YP_002389375.1\| putative fructose-specific phosphotransferase system protein FrvX [...	261.0	[0..1]	[356..1]
gi\|75258118, gi\|... - gi\|75258118\|ref\|ZP_00729579.1\| COG1363: Cellulase M and related proteins [Escherichia coli E22], gi\|... gi\|209921376, gi... - gi\|209921376\|ref\|YP_002295460.1\| putative fructose-specific phosphotransferase system protein FrvX [... gi\|194427447, gi... - gi\|75211287\|ref\|ZP_00711386.1\| COG1363: Cellulase M and related proteins [Escherichia coli B171], gi...	260.0	[0..1]	[356..1]

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Predicted Domain #1

Region A:
Residues: [1-356]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIELLQQLC EASAVSGDEQ EVRDILINTL EPCVNEITFD GLGSFVARKG NKGPKVAVVG  60
   61 HMDEVGFMVT HIDESGFLRF TTIGGWWNQS MLNHRVTIRT HKGVKIPGVI GSVAPHALTE 120
  121 KQKQQPLSFD EMFIDIGANS REEVEKRGVE IGNFISPEAN FACWGEDKVV GKALDNRIGC 180
  181 AMMAELLQTV NNPEITLYGV GSVEEEVGLR GAQTSAEHIK PDVVIVLDTA VAGDVPGIDN 240
  241 IKYPLKLGQG PGLMLFDKRY FPNQKLVAAL KSCAAHNDLP LQFSTMKTGA TDGGRYNVMG 300
  301 GGRPVVALCL PTRYLHANSG MISKADYEAL LTLIRGFLTT LTAEKVNAFS QFRQVD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	68.522879
Match:	1vheA
Description:	Crystal structure of a aminopeptidase/glucanase homolog
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	3.33046421415418	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	2.92029075689694	bayes_pls_golite062009
hydrolase activity	2.67636468634585	bayes_pls_golite062009
exopeptidase activity	1.92607656615233	bayes_pls_golite062009
catalytic activity	1.76936806579991	bayes_pls_golite062009
metallopeptidase activity	1.36622846208556	bayes_pls_golite062009
carboxypeptidase activity	1.26773013808101	bayes_pls_golite062009
metalloexopeptidase activity	0.675221914435689	bayes_pls_golite062009
metallocarboxypeptidase activity	0.406156022753981	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: