YRC Public Data Repository - Protein Structure Prediction

Protein:	FIS_ECOLI
Organism:	Escherichia coli
Length:	98 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FIS_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|78701632, gi\|... - gi\|78701632\|ref\|ZP_00866081.1\| Helix-turn-helix, Fis-type [Alkalilimnicola ehrlichei MLHE-1], gi\|785...	2.0E-20	[4..97]	[563..656]
gi\|71486651, gi\|... - gi\|71547773\|ref\|ZP_00668332.1\| Helix-turn-helix, Fis-type [Syntrophobacter fumaroxidans MPOB], gi\|71...	7.0E-20	[4..97]	[363..456]
gi\|88925965, gi\|... - gi\|88944328\|ref\|ZP_01147651.1\| Helix-turn-helix, Fis-type [Desulfotomaculum reducens MI-1], gi\|88925...	8.0E-20	[4..97]	[356..446]
gi\|53759887, gi\|... - gi\|91774570\|ref\|YP_544326.1\| two component, sigma54 specific, Fis family transcriptional regulator [...	9.0E-20	[4..98]	[357..451]
gi\|85774925, gi\|... - gi\|86158414\|ref\|YP_465199.1\| two component, sigma54 specific, Fis family transcriptional regulator [...	1.0E-19	[4..97]	[365..459]
gi\|94968805, gi\|... - gi\|94968805\|ref\|YP_590853.1\| two component, sigma54 specific, Fis family transcriptional regulator [...	5.0E-19	[4..98]	[363..454]
gi\|28203882, gi\|... - gi\|28211441\|ref\|NP_782385.1\| putative sigma-54 interacting protein [Clostridium tetani E88], gi\|2820...	6.0E-19	[4..97]	[502..594]
gi\|91200560 - gi\|91200560\|emb\|CAJ73609.1\| strongly similar to sigma 54 response regulator [Candidatus Kuenenia stu...	8.0E-19	[4..98]	[371..471]
gi\|48847327, gi\|... - gi\|78223199\|ref\|YP_384946.1\| two component, sigma54 specific, Fis family transcriptional regulator [...	8.0E-19	[4..98]	[365..454]
gi\|98661577 - gi\|98661577\|dbj\|GAA01428.1\| unnamed protein product [Pelotomaculum thermopropionicum SI]	8.0E-19	[4..97]	[101..192]

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Predicted Domain #1

Region A:
Residues: [1-98]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFEQRVNSDV LTVSTVNSQD QVTQKPLRDS VKQALKNYFA QLNGQDVNDL YELVLAEVEQ  60
   61 PLLDMVMQYT RGNQTRAALM MGINRGTLRK KLKKYGMN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.30103
Match:	1etqA
Description:	FIS protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.57523737355937	bayes_pls_golite062009
DNA binding	3.00143272905695	bayes_pls_golite062009
nucleic acid binding	2.89825020286436	bayes_pls_golite062009
transcription factor activity	2.53664874743748	bayes_pls_golite062009
binding	1.68817361068715	bayes_pls_golite062009
transcription repressor activity	1.65547085597412	bayes_pls_golite062009
sequence-specific DNA binding	0.46503550280898	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.24108783215685	bayes_pls_golite062009
protein binding	0.111941607625758	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: