YRC Public Data Repository - Protein Structure Prediction

Protein:	EX1_ECOLI
Organism:	Escherichia coli
Length:	475 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EX1_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|90323813, gi\|... - gi\|90415078\|ref\|ZP_01223036.1\| putative exonuclease I [Photobacterium profundum 3TCK], gi\|90323813\|g...	539.0	[0..3]	[470..1]
gi\|46913312, gi\|... - gi\|54308882\|ref\|YP_129902.1\| exonuclease I [Photobacterium profundum SS9], gi\|46913312\|emb\|CAG20100....	539.0	[0..3]	[470..1]
gi\|151939187, gi... - gi\|75856580\|ref\|ZP_00764206.1\| COG2925: Exonuclease I [Vibrio sp. Ex25], gi\|254228381\|ref\|ZP_0492180...	539.0	[0..3]	[474..1]
gi\|83571274, gi\|... - gi\|83571274\|ref\|ZP_00922715.1\| COG2925: Exonuclease I [Shigella dysenteriae 1012], gi\|194431379\|ref\|...	539.0	[0..1]	[475..1]
gi\|27362277, gi\|... - gi\|27366077\|ref\|NP_761605.1\| exonuclease I [Vibrio vulnificus CMCP6], gi\|27362277\|gb\|AAO11132.1\|AE01...	537.0	[0..3]	[475..1]
gi\|26108790, gi\|... - gi\|26248386\|ref\|NP_754426.1\| Exodeoxyribonuclease I [Escherichia coli CFT073], gi\|26108790\|gb\|AAN809... gi\|237704470, gi... - gi\|237704470\|ref\|ZP_04534951.1\| exodeoxyribonuclease I [Escherichia sp. 3_2_53FAA], gi\|226900836\|gb\|...	537.0	[0..1]	[475..17]
gi\|90439496, gi\|... - gi\|90578663\|ref\|ZP_01234473.1\| putative exonuclease I [Vibrio angustum S14], gi\|90439496\|gb\|EAS64677...	537.0	[0..3]	[475..1]
gi\|227887062, gi... - gi\|227887062\|ref\|ZP_04004867.1\| exodeoxyribonuclease I [Escherichia coli 83972], gi\|227835412\|gb\|EEJ... gi\|161486193 - gi\|161486193\|ref\|NP_754426.2\| exonuclease I [Escherichia coli CFT073] gi\|191170056, gi... - gi\|191170056\|ref\|ZP_03031610.1\| exodeoxyribonuclease I [Escherichia coli F11], gi\|190909572\|gb\|EDV69... gi\|110343817, gi... - gi\|110642225\|ref\|YP_669955.1\| exonuclease I [Escherichia coli 536], gi\|110343817\|gb\|ABG70054.1\| exod...	537.0	[0..1]	[475..1]
gi\|73856030, gi\|... - gi\|74312553\|ref\|YP_310972.1\| exonuclease I [Shigella sonnei Ss046], gi\|73856030\|gb\|AAZ88737.1\| deoxy...	537.0	[0..1]	[475..1]
gi\|13362281, gi\|... - gi\|15832067\|ref\|NP_310840.1\| exonuclease I [Escherichia coli O157:H7], gi\|13362281\|dbj\|BAB36236.1\| e... gi\|13362281, gi\|... - gi\|15832067\|ref\|NP_310840.1\| exonuclease I [Escherichia coli O157:H7 str. Sakai], gi\|13362281\|dbj\|BA... gi\|168764097, gi... - gi\|189365832\|gb\|EDU84248.1\| exodeoxyribonuclease I [Escherichia coli O157:H7 str. EC4501], gi\|168764... gi\|25289111 - pir\|\|E90980 exonuclease I [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952) gi\|217329517, gi... - gi\|217329517\|ref\|ZP_03445596.1\| exodeoxyribonuclease I [Escherichia coli O157:H7 str. TW14588], gi\|2... gi\|226237418 - gi\|226237418\|dbj\|BAH46940.1\| exonuclease I [Escherichia coli O55:H7]	537.0	[0..1]	[475..1]

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Predicted Domain #1

Region A:
Residues: [1-475]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNDGKQQST FLFHDYETFG THPALDRPAQ FAAIRTDSEF NVIGEPEVFY CKPADDYLPQ  60
   61 PGAVLITGIT PQEARAKGEN EAAFAARIHS LFTVPKTCIL GYNNVRFDDE VTRNIFYRNF 120
  121 YDPYAWSWQH DNSRWDLLDV MRACYALRPE GINWPENDDG LPSFRLEHLT KANGIEHSNA 180
  181 HDAMADVYAT IAMAKLVKTR QPRLFDYLFT HRNKHKLMAL IDVPQMKPLV HVSGMFGAWR 240
  241 GNTSWVAPLA WHPENRNAVI MVDLAGDISP LLELDSDTLR ERLYTAKTDL GDNAAVPVKL 300
  301 VHINKCPVLA QANTLRPEDA DRLGINRQHC LDNLKILREN PQVREKVVAI FAEAEPFTPS 360
  361 DNVDAQLYNG FFSDADRAAM KIVLETEPRN LPALDITFVD KRIEKLLFNY RARNFPGTLD 420
  421 YAEQQRWLEH RRQVFTPEFL QGYADELQML VQQYADDKEK VALLKALWQY AEEIV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	152.0
Match:	1fxxA
Description:	Exonuclease I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	2.30893115816458	bayes_pls_golite062009
ribonuclease activity	2.27368058469313	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	2.26022264830742	bayes_pls_golite062009
nuclease activity	1.81796593394339	bayes_pls_golite062009
endonuclease activity	1.79009816048707	bayes_pls_golite062009
exonuclease activity	1.64964907710028	bayes_pls_golite062009
catalytic activity	1.62277843225829	bayes_pls_golite062009
endoribonuclease activity	1.5391920929568	bayes_pls_golite062009
ribonuclease H activity	1.03274213246433	bayes_pls_golite062009
exodeoxyribonuclease I activity	0.70661333047946	bayes_pls_golite062009
deoxyribonuclease activity	0.63299586096139	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.62821439153618	bayes_pls_golite062009
exoribonuclease activity	0.1529022053594	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	0.0105328395026505	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: