YRC Public Data Repository - Protein Structure Prediction

Protein:	EVGS_ECOLI
Organism:	Escherichia coli
Length:	1197 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EVGS_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|6573136 - gi\|6573136\|gb\|AAF17564.1\|AF201841_1 sensor protein EvgS4 [Escherichia coli]	666.0	[0..1]	[1197..1]
gi\|110615871, gi... - gi\|110806323\|ref\|YP_689843.1\| hybrid sensory histidine kinase in two-component regulatory system wit...	665.0	[0..1]	[1197..1]
gi\|24113731, gi\|... - gi\|24113731\|ref\|NP_708241.1\| hybrid sensory histidine kinase in two-component regulatory system with...	665.0	[0..1]	[1197..1]
gi\|30042032, gi\|... - gi\|30063777\|ref\|NP_837948.1\| hybrid sensory histidine kinase in two-component regulatory system with...	662.0	[0..1]	[1197..1]
gi\|81246249, gi\|... - gi\|82544838\|ref\|YP_408785.1\| hybrid sensory histidine kinase in two-component regulatory system with...	662.0	[0..1]	[1197..1]
gi\|73856395, gi\|... - gi\|74312918\|ref\|YP_311337.1\| hybrid sensory histidine kinase in two-component regulatory system with...	660.0	[0..1]	[1197..1]
gi\|13362719, gi\|... - gi\|15832503\|ref\|NP_311276.1\| hybrid sensory histidine kinase in two-component regulatory system with... gi\|254794332, gi... - gi\|254794332\|ref\|YP_003079169.1\| hybrid sensory histidine kinase in two-component regulatory system ... gi\|12516740, gi\|... - gi\|15802913\|ref\|NP_288940.1\| hybrid sensory histidine kinase in two-component regulatory system with... gi\|209764542, gi... - pir\|\|C85879 probable sensor for regulator EvgA evgS [imported] - Escherichia coli (strain O157:H7, s... gi\|208813535, gi... - gi\|208813535\|ref\|ZP_03254864.1\| sensor histidine kinase/response regulator EvgS [Escherichia coli O1... gi\|208740123, gi... - gi\|208820000\|ref\|ZP_03260320.1\| sensor histidine kinase/response regulator EvgS [Escherichia coli O1... gi\|168787283, gi... - gi\|189372943\|gb\|EDU91359.1\| sensor histidine kinase/response regulator EvgS [Escherichia coli O157:H... gi\|168800705, gi... - gi\|189377054\|gb\|EDU95470.1\| sensor histidine kinase/response regulator EvgS [Escherichia coli O157:H... EVGS_ECO57 - Sensor protein EvgS OS=Escherichia coli O157:H7 GN=evgS PE=3 SV=1 gi\|195938723 - gi\|195938723\|ref\|ZP_03084105.1\| hybrid sensory histidine kinase in two-component regulatory system w... gi\|208726491, gi... - gi\|208806690\|ref\|ZP_03249027.1\| sensor histidine kinase/response regulator EvgS [Escherichia coli O1... gi\|168763545, gi... - gi\|189366312\|gb\|EDU84728.1\| sensor histidine kinase/response regulator EvgS [Escherichia coli O157:H... gi\|168770938, gi... - gi\|189360184\|gb\|EDU78603.1\| sensor histidine kinase/response regulator EvgS [Escherichia coli O157:H... gi\|168772797, gi... - gi\|187771129\|gb\|EDU34973.1\| sensor histidine kinase/response regulator EvgS [Escherichia coli O157:H... gi\|189002202, gi... - gi\|189002202\|gb\|EDU71188.1\| sensor histidine kinase/response regulator EvgS [Escherichia coli O157:H... gi\|168748323, gi... - gi\|188017187\|gb\|EDU55309.1\| sensor histidine kinase/response regulator EvgS [Escherichia coli O157:H... gi\|189355573, gi... - gi\|189355573\|gb\|EDU73992.1\| sensor histidine kinase/response regulator EvgS [Escherichia coli O157:H...	655.0	[0..1]	[1195..1]
gi\|110344151, gi... - gi\|110642559\|ref\|YP_670289.1\| hybrid sensory histidine kinase in two-component regulatory system wit... gi\|191173763, gi... - gi\|191173763\|ref\|ZP_03035285.1\| sensor histidine kinase/response regulator EvgS [Escherichia coli F1...	654.0	[0..1]	[1197..1]

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Predicted Domain #1

Region A:
Residues: [1-289]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFLPYIFLL CCGLWSTISF ADEDYIEYRG ISSNNRVTLD PLRLSNKELR WLASKKNLVI  60
   61 AVHKSQTATL LHTDSQQRVR GINADYLNLL KRALNIKLTL REYADHQKAM DALAEGEVDI 120
  121 VLSHLVTSPP LNNDIAATKP LIITFPALVT TLHDSMRPLT SPKPVNIARV ANYPPDEVIH 180
  181 QSFPKATIIS FTNLYQALAS VSAGHNDYFI GSNIITSSMI SRYFTHSLNV VKYYNSPRQY 240
  241 NFFLTRKESV ILNEVLNRFV DALTNEVRYE VSQNWLDTGN LAFLNKPLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.39794
Match:	2ia4A
Description:	No description for 2ia4A was found.

Predicted Domain #2

Region A:
Residues: [290-537]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTEHEKQWIK QHPNLKVLEN PYSPPYSMTD ENGSVRGVMG DILNIITLQT GLNFSPITVS  60
   61 HNIHAGTQLS PGGWDIIPGA IYSEDRENNV LFAEAFITTP YVFVMQKAPD SEQTLKKGMK 120
  121 VAIPYYYELH SQLKEMYPEV EWIQVDNASA AFHKVKEGEL DALVATQLNS RYMIDHYYPN 180
  181 ELYHFLIPGV PNASLSFAFP RGEPELKDII NKALNAIPPS EVLRLTEKWI KMPNVTIDTW 240
  241 DLYSEQFY

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	7.28
Match:	1gggA
Description:	Glutamine-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.22974981386189	bayes_pls_golite062009
catalytic activity	1.01902493577147	bayes_pls_golite062009
transcription regulator activity	0.16461666107495	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [538-677]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVTTLSVLLV GSSLLWGFYL LRSVRRRKVI QGDLENQISF RKALSDSLPN PTYVVNWQGN  60
   61 VISHNSAFEH YFTADYYKNA MLPLENSDSP FKDVFSNAHE VTAETKENRT IYTQVFEIDN 120
  121 GIEKRCINHW HTLCNLPASD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.0
Match:	1v9yA
Description:	Crystal Structure of the heme PAS sensor domain of Ec DOS (ferric form)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.79230776794479	bayes_pls_golite062009
two-component response regulator activity	1.45691562840107	bayes_pls_golite062009
transcription regulator activity	1.13913685347546	bayes_pls_golite062009
protein binding	1.0133195984081	bayes_pls_golite062009
DNA binding	0.73243452463464	bayes_pls_golite062009
nucleic acid binding	0.6782569041078	bayes_pls_golite062009
two-component sensor activity	0.58151911764083	bayes_pls_golite062009
protein histidine kinase activity	0.56538125817883	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	0.518111391350209	bayes_pls_golite062009
signal transducer activity	0.441034662376355	bayes_pls_golite062009
molecular transducer activity	0.441034662376355	bayes_pls_golite062009
transcription factor activity	0.36759096137141	bayes_pls_golite062009
catalytic activity	0.285447488878019	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [678-945]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAVYICGWQD ITETRDLINA LEVEKNKAIK ATVAKSQFLA TMSHEIRTPI SSIMGFLELL  60
   61 SGSGLSKEQR VEAISLAYAT GQSLLGLIGE ILDVDKIESG NYQLQPQWVD IPTLVQNTCH 120
  121 SFGAIAASKS IALSCSSTFP EHYLVKIDPQ AFKQVLSNLL SNALKFTTEG AVKITTSLGH 180
  181 IDDNHAVIKM TIMDSGSGLS QEEQQQLFKR YSQTSAGRQQ TGSGLGLMIC KELIKNMQGD 240
  241 LSLESHPGIG TTFTITIPVE ISQQVATV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.221849
Match:	2c2aA
Description:	Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [946-1079]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAKAEQPITL PEKLSILIAD DHPTNRLLLK RQLNLLGYDV DEATDGVQAL HKVSMQHYDL  60
   61 LITDVNMPNM DGFELTRKLR EQNSSLPIWG LTANAQANER EKGLSCGMNL CLFKPLTLDV 120
  121 LKTHLSQLHQ VAHI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	25.39794
Match:	2ayxA
Description:	No description for 2ayxA was found.

Predicted Domain #6

Region A:
Residues: [1080-1197]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APQYRHLDIE ALKNNTANDL QLMQEILMTF QHETHKDLPA AFQALEAGDN RTFHQCIHRI  60
   61 HGAANILNLQ KLINISHQLE ITPVSDDSKP EILQLLNSVK EHIAELDQEI AVFCQKND

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	17.154902
Match:	2d1vA
Description:	No description for 2d1vA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: