YRC Public Data Repository - Protein Structure Prediction

Protein:	ERA_ECOLI
Organism:	Escherichia coli
Length:	301 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|24053009, gi\|... - gi\|24113908\|ref\|NP_708418.1\| GTP-binding protein Era [Shigella flexneri 2a str. 301], gi\|24053009\|gb... ERA_SHIFL - GTPase Era OS=Shigella flexneri GN=era PE=3 SV=1 gi\|30042224, gi\|... - gi\|30063968\|ref\|NP_838139.1\| GTP-binding protein Era [Shigella flexneri 2a str. 2457T], gi\|30042224\|...	261.0	[0..1]	[301..1]
ERA_SHIF8 - GTPase Era OS=Shigella flexneri serotype 5b (strain 8401) GN=era PE=3 SV=1	261.0	[0..1]	[301..1]
ERA_SHIBS - GTPase Era OS=Shigella boydii serotype 4 (strain Sb227) GN=era PE=3 SV=1 ERA_SHISS - GTPase Era OS=Shigella sonnei (strain Ss046) GN=era PE=3 SV=1 gi\|193064069, gi... - gi\|75257990\|ref\|ZP_00729464.1\| COG1159: GTPase [Escherichia coli E22], gi\|193064069\|ref\|ZP_03045154.... gi\|192958287, gi... - gi\|75237688\|ref\|ZP_00721704.1\| COG1159: GTPase [Escherichia coli E110019], gi\|193068335\|ref\|ZP_03049... gi\|191174026, gi... - gi\|75237415\|ref\|ZP_00721450.1\| COG1159: GTPase [Escherichia coli F11], gi\|191174026\|ref\|ZP_03035543.... ERA_ECOSM - GTPase Era OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=era PE=3 SV=1 gi\|190901976, gi... - gi\|75228859\|ref\|ZP_00715460.1\| COG1159: GTPase [Escherichia coli B7A], gi\|191167969\|ref\|ZP_03029771.... gi\|194412670, gi... - gi\|75209490\|ref\|ZP_00709715.1\| COG1159: GTPase [Escherichia coli B171], gi\|194429262\|ref\|ZP_03061789... ERA_ECO27 - GTPase Era OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=era PE=3 SV=1 ERA_ECO24 - GTPase Era OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=era PE=3 SV=1 ERA_ECOSE - GTPase Era OS=Escherichia coli (strain SE11) GN=era PE=3 SV=1 ERA_SHIB3 - GTPase Era OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=era PE=3 SV=1 ERA_ECO45 - GTPase Era OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=era PE=3 SV=1 gi\|83570802, gi\|... - gi\|83570802\|ref\|ZP_00922245.1\| COG1159: GTPase [Shigella dysenteriae 1012], gi\|194432158\|ref\|ZP_0306... ERA_ECO8A - GTPase Era OS=Escherichia coli O8 (strain IAI1) GN=era PE=3 SV=1 ERA_ECOK1 - GTPase Era OS=Escherichia coli O1:K1 / APEC GN=era PE=3 SV=1 ERA_ECO55 - GTPase Era OS=Escherichia coli (strain 55989 / EAEC) GN=era PE=3 SV=1 ERA_ECO81 - GTPase Era OS=Escherichia coli O81 (strain ED1a) GN=era PE=3 SV=1 ERA_ECOLU - GTPase Era OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=era PE=3 SV=1 ERA_ECO7I - GTPase Era OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=era PE=3 SV=1 gi\|227835952, gi... - gi\|227887602\|ref\|ZP_04005407.1\| GTP-binding protein Era [Escherichia coli 83972], gi\|227835952\|gb\|EE... gi\|226901442, gi... - gi\|237705076\|ref\|ZP_04535557.1\| GTP-binding protein era [Escherichia sp. 3_2_53FAA], gi\|226901442\|gb... ERA_ECOL6 - GTPase Era OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=era PE=3 SV=1 ERA_ECOL5 - GTPase Era OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=era PE=3 SV=1 ERA_ECOUT - GTPase Era OS=Escherichia coli (strain UTI89 / UPEC) GN=era PE=3 SV=1 ERA_ECOL6 - GTPase Era OS=Escherichia coli O6 GN=era PE=3 SV=1 sp\|B7UH06\|ERA_ECO27 - GTPase Era OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=era PE=3 SV=1	260.0	[0..1]	[301..1]
gi\|208807726, gi... - gi\|208807726\|ref\|ZP_03250063.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. EC4206], gi\|2... gi\|195936713 - gi\|195936713\|ref\|ZP_03082095.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. EC4024] gi\|189378591, gi... - gi\|189378591\|gb\|EDU97007.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. EC508], gi\|168798... gi\|189372292, gi... - gi\|189372292\|gb\|EDU90708.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. EC869], gi\|168787... gi\|217326912, gi... - gi\|217326912\|ref\|ZP_03442995.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. TW14588], gi\|... ERA_ECO5E - GTPase Era OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=era PE=3 SV=1 gi\|208818911, gi... - gi\|208818911\|ref\|ZP_03259231.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. EC4042], gi\|2... gi\|208812920, gi... - gi\|208812920\|ref\|ZP_03254249.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. EC4045], gi\|2... gi\|189355284, gi... - gi\|189355284\|gb\|EDU73703.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. EC4401], gi\|16875... gi\|188017077, gi... - gi\|188017077\|gb\|EDU55199.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. EC4113], gi\|16874... gi\|189003180, gi... - gi\|189003180\|gb\|EDU72166.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. EC4076], gi\|16877... gi\|168773508, gi... - gi\|187770556\|gb\|EDU34400.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. EC4196], gi\|16877... gi\|189362313, gi... - gi\|189362313\|gb\|EDU80732.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. EC4486], gi\|16876... gi\|168761187, gi... - gi\|189368417\|gb\|EDU86833.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. EC4501], gi\|16876... gi\|209762892, gi... - pir\|\|H91057 GTP-binding protein [imported] - Escherichia coli (strain O157:H7, substrain RIMD 050995... gi\|13362903, gi\|... - gi\|15832686\|ref\|NP_311459.1\| GTP-binding protein Era [Escherichia coli O157:H7 str. Sakai], gi\|13362... ERA_ECO57 - GTPase Era OS=Escherichia coli O157:H7 GN=era PE=3 SV=1 gi\|254794516, gi... - gi\|254794516\|ref\|YP_003079353.1\| membrane-associated, 16S rRNA-binding GTPase [Escherichia coli O157...	260.0	[0..1]	[301..1]
gi\|213161854 - gi\|213161854\|ref\|ZP_03347564.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar... gi\|213420939 - gi\|213420939\|ref\|ZP_03354005.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar... gi\|213425277 - gi\|213425277\|ref\|ZP_03358027.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar... ERA_SALTI - GTPase Era OS=Salmonella typhi GN=era PE=3 SV=1 gi\|29136436, gi\|... - gi\|29140811\|ref\|NP_804153.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar Ty... ERA_SALTI - GTP-binding protein era homolog OS=Salmonella typhi GN=era PE=3 SV=1 gi\|16761492 - gi\|16761492\|ref\|NP_457109.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar Ty... gi\|213613050 - gi\|213613050\|ref\|ZP_03370876.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar... gi\|213646354 - gi\|213646354\|ref\|ZP_03376407.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar... gi\|214000667 - gi\|214000667\|ref\|ZP_03411402.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar...	259.0	[0..1]	[301..1]
gi\|37527215, gi\|... - gi\|37527215\|ref\|NP_930559.1\| GTP-binding protein Era [Photorhabdus luminescens subsp. laumondii TTO1...	259.0	[0..1]	[301..1]
ERA_SALPA - GTPase Era OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=era PE=3 SV=1 ERA_SALCH - GTPase Era OS=Salmonella choleraesuis GN=era PE=3 SV=1 ERA_SALPC - GTPase Era OS=Salmonella paratyphi C (strain RKS4594) GN=era PE=3 SV=1 ERA_SALEP - GTPase Era OS=Salmonella enteritidis PT4 (strain P125109) GN=era PE=3 SV=1 ERA_SALG2 - GTPase Era OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=era PE=3 SV=1 ERA_SALPA - GTPase Era OS=Salmonella paratyphi A GN=era PE=3 SV=1 gi\|204929711, gi... - gi\|204929711\|ref\|ZP_03220785.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar... ERA_SALCH - GTP-binding protein era homolog OS=Salmonella choleraesuis GN=era PE=3 SV=1 gi\|199603868, gi... - gi\|200386770\|ref\|ZP_03213382.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar... gi\|238912698 - gi\|238912698\|ref\|ZP_04656535.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar... ERA_SALCH - GTPase Era OS=Salmonella choleraesuis (strain SC-B67) GN=era PE=3 SV=1 ERA_SALDC - GTPase Era OS=Salmonella dublin (strain CT_02021853) GN=era PE=3 SV=1 ERA_SALPK - GTPase Era OS=Salmonella paratyphi A (strain AKU_12601) GN=era PE=3 SV=1 ERA_SALA4 - GTPase Era OS=Salmonella agona (strain SL483) GN=era PE=3 SV=1 ERA_SALSV - GTPase Era OS=Salmonella schwarzengrund (strain CVM19633) GN=era PE=3 SV=1 gi\|194456363, gi... - gi\|194469999\|ref\|ZP_03075983.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar... gi\|205341982, gi... - gi\|205341982\|gb\|EDZ28746.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar Wel... gi\|195630802, gi... - gi\|195630802\|gb\|EDX49394.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar New... gi\|168261369, gi... - gi\|205349353\|gb\|EDZ35984.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar Had... gi\|197288837, gi... - gi\|197288837\|gb\|EDY28210.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar Sch... gi\|205333611, gi... - gi\|205333611\|gb\|EDZ20375.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar Ken... gi\|167549388, gi... - gi\|205325335\|gb\|EDZ13174.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar Sai...	259.0	[0..1]	[301..1]
gi\|84780284, gi\|... - gi\|85059764\|ref\|YP_455466.1\| GTP-binding protein Era [Sodalis glossinidius str. 'morsitans'], gi\|847...	259.0	[0..1]	[301..1]
lcl\|NC_016856.1_... - [gene=era] [protein=GTP-binding protein Era] [protein_id=YP_005238687.1] [location=complement(277547... ERA_SALTY - GTP-binding protein era OS=Salmonella typhimurium GN=era PE=3 SV=2 ERA_SALHS - GTPase Era OS=Salmonella heidelberg (strain SL476) GN=era PE=3 SV=1 ERA_SALNS - GTPase Era OS=Salmonella newport (strain SL254) GN=era PE=3 SV=1 gi\|167992711, gi... - gi\|205329140\|gb\|EDZ15904.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar 4,[... ERA_SALTY - GTPase Era OS=Salmonella typhimurium GN=era PE=3 SV=2 ERA_SALTY - GTPase Era OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=era PE=3 SV=2 gi\|197240033, gi... - gi\|197261778\|ref\|ZP_03161852.1\| GTP-binding protein Era [Salmonella enterica subsp. enterica serovar...	258.0	[0..1]	[301..1]
ERA_SHIDS - GTPase Era OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=era PE=3 SV=1	257.0	[0..1]	[301..1]

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Predicted Domain #1

Region A:
Residues: [1-301]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIDKSYCGF IAIVGRPNVG KSTLLNKLLG QKISITSRKA QTTRHRIVGI HTEGAYQAIY  60
   61 VDTPGLHMEE KRAINRLMNK AASSSIGDVE LVIFVVEGTR WTPDDEMVLN KLREGKAPVI 120
  121 LAVNKVDNVQ EKADLLPHLQ FLASQMNFLD IVPISAETGL NVDTIAAIVR KHLPEATHHF 180
  181 PEDYITDRSQ RFMASEIIRE KLMRFLGAEL PYSVTVEIER FVSNERGGYD INGLILVERE 240
  241 GQKKMVIGNK GAKIKTIGIE ARKDMQEMFE APVHLELWVK VKSGWADDER ALRSLGYVDD 300
  301 L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.69897
Match:	1egaA
Description:	GTPase Era, N-terminal domain; GTPase Era C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	0.74089985308964	bayes_pls_golite062009
catalytic activity	0.471337605075652	bayes_pls_golite062009
binding	0.437847571554934	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: