YRC Public Data Repository - Protein Structure Prediction

Protein:	ENVZ_ECOLI
Organism:	Escherichia coli
Length:	450 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ENVZ_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|45440000, gi\|... - gi\|45440000\|ref\|NP_991539.1\| osmolarity sensor protein [Yersinia pestis biovar Microtus str. 91001],...	280.0	[0..1]	[450..1]
gi\|25298449 - pir\|\|AF0017 osmolarity sensor protein (EC 2.7.3.-) [imported] - Yersinia pestis (strain CO92) gi\|51598053, gi\|... - gi\|51598053\|ref\|YP_072244.1\| osmolarity sensor protein [Yersinia pseudotuberculosis IP 32953], gi\|51... gi\|22127787, gi\|... - gi\|22127787\|ref\|NP_671210.1\| osmolarity sensor protein [Yersinia pestis KIM], gi\|21960916\|gb\|AAM8746... Q664K6\|Q664K6_YERPS - Osmolarity sensor protein precursor - Yersinia pseudotuberculosis gi\|218927348, gi... - gi\|218927348\|ref\|YP_002345223.1\| osmolarity sensor protein [Yersinia pestis CO92], gi\|16120480\|ref\|N... gi\|166010415, gi... - gi\|166010415\|ref\|ZP_02231313.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Antiqua str. ... gi\|229706450, gi... - gi\|229836382\|ref\|ZP_04456549.1\| sensory histidine kinase in two-component regulatory system with Omp... gi\|165928059, gi... - gi\|165928059\|ref\|ZP_02223891.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Orientalis st... gi\|229696359, gi... - gi\|229839993\|ref\|ZP_04460152.1\| sensory histidine kinase in two-component regulatory system with Omp... gi\|167051326, gi... - gi\|167398822\|ref\|ZP_02304346.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Antiqua str. ... gi\|229690384, gi... - gi\|229842074\|ref\|ZP_04462229.1\| sensory histidine kinase in two-component regulatory system with Omp... gi\|77633467, gi\|... - gi\|77633467\|ref\|ZP_00795597.1\| COG0642: Signal transduction histidine kinase [Yersinia pestis Angola... gi\|166213218, gi... - gi\|166213218\|ref\|ZP_02239253.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Antiqua str. ... gi\|167425631, gi... - gi\|167425631\|ref\|ZP_02317384.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Mediaevalis s... gi\|166963036, gi... - gi\|167419042\|ref\|ZP_02310795.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Orientalis st... gi\|186700279, gi... - gi\|186897253\|ref\|YP_001874365.1\| osmolarity sensor protein [Yersinia pseudotuberculosis PB1/+], gi\|1... gi\|170022434, gi... - gi\|170022434\|ref\|YP_001718939.1\| osmolarity sensor protein [Yersinia pseudotuberculosis YPIII], gi\|1... gi\|165936352, gi... - gi\|89105813\|ref\|ZP_01178326.1\| COG0642: Signal transduction histidine kinase [Yersinia pestis biovar... gi\|108809323, gi... - gi\|108809323\|ref\|YP_653239.1\| osmolarity sensor protein [Yersinia pestis Antiqua], gi\|108781236\|gb\|A... gi\|108777736, gi... - gi\|229904625\|ref\|ZP_04519736.1\| sensory histidine kinase in two-component regulatory system with Omp... gi\|149290227, gi... - gi\|150260819\|ref\|ZP_01917547.1\| osmolarity sensor protein [Yersinia pestis CA88-4125], gi\|149290227\|... gi\|145209083, gi... - gi\|145597387\|ref\|YP_001161462.1\| osmolarity sensor protein [Yersinia pestis Pestoides F], gi\|1452090...	280.0	[0..1]	[450..1]
gi\|152959614, gi... - gi\|77631119\|ref\|ZP_00793705.1\| COG0642: Signal transduction histidine kinase [Yersinia pseudotubercu...	279.0	[0..1]	[450..1]
gi\|218429245, gi... - gi\|218691681\|ref\|YP_002399893.1\| osmolarity sensor protein [Escherichia coli ED1a], gi\|218429245\|emb... gi\|190908126, gi... - gi\|75241505\|ref\|ZP_00725350.1\| COG0642: Signal transduction histidine kinase [Escherichia coli F11],... gi\|110643637, gi... - gi\|110643637\|ref\|YP_671367.1\| osmolarity sensor protein [Escherichia coli 536], gi\|110345229\|gb\|ABG7...	278.0	[0..1]	[450..1]
gi\|15833500, gi\|... - gi\|15833500\|ref\|NP_312273.1\| osmolarity sensor protein [Escherichia coli O157:H7 str. Sakai], gi\|133... gi\|15833500, gi\|... - gi\|15833500\|ref\|NP_312273.1\| osmolarity sensor protein [Escherichia coli O157:H7], gi\|13363720\|dbj\|B... gi\|208739839, gi... - gi\|208819716\|ref\|ZP_03260036.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4042... gi\|25298452, gi\|... - pir\|\|E86005 protein histidine kinase/phosphatase EnvZ [imported] - Escherichia coli (strain O157:H7,... gi\|208734794, gi... - gi\|208813517\|ref\|ZP_03254846.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4045... gi\|217321412, gi... - gi\|217325191\|ref\|ZP_03441275.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. TW1458... gi\|12518031, gi\|... - gi\|15803908\|ref\|NP_289944.1\| osmolarity sensor protein [Escherichia coli O157:H7 EDL933], gi\|1251803... gi\|209158826, gi... - gi\|209397426\|ref\|YP_002272839.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC411... gi\|168797174, gi... - gi\|189379930\|gb\|EDU98346.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC508], gi... gi\|189374410, gi... - gi\|189374410\|gb\|EDU92826.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC869], gi... gi\|208807616, gi... - gi\|208807616\|ref\|ZP_03249953.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4206... gi\|195934893 - gi\|195934893\|ref\|ZP_03080275.1\| osmolarity sensor protein [Escherichia coli O157:H7 str. EC4024] gi\|189364652, gi... - gi\|189364652\|gb\|EDU83071.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4486], g... gi\|189369894, gi... - gi\|189369894\|gb\|EDU88310.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4501], g... gi\|189002223, gi... - gi\|189002223\|gb\|EDU71209.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4076], g... gi\|168772705, gi... - gi\|187771797\|gb\|EDU35641.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4196], g... gi\|189359046, gi... - gi\|189359046\|gb\|EDU77465.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4401], g... gi\|168747119, gi... - gi\|188018349\|gb\|EDU56471.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4113], g... gi\|254594719, gi... - gi\|254795319\|ref\|YP_003080156.1\| sensory histidine kinase in two-component regulatory system with Om...	277.0	[0..1]	[450..1]
gi\|79091, gi\|47665 - pir\|\|S01367 inner membrane protein envZ - Salmonella typhimurium, gi\|47665\|emb\|CAA30935.1\| unnamed p... gi\|47665\|emb\|CAA... - unnamed protein product [Salmonella typhimurium]	277.0	[0..1]	[450..1]
gi\|56415416, gi\|... - gi\|56415416\|ref\|YP_152491.1\| osmolarity sensor protein [Salmonella enterica subsp. enterica serovar ... gi\|161365905, gi... - gi\|161616541\|ref\|YP_001590506.1\| osmolarity sensor protein [Salmonella enterica subsp. enterica sero... ENVZ_SALTY - Osmolarity sensor protein envZ OS=Salmonella typhimurium GN=envZ PE=3 SV=2 ENVZ_SALTY - Osmolarity sensor protein EnvZ OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=en... lcl\|NC_016856.1_... - [gene=envZ] [protein=osmolarity sensor protein] [protein_id=YP_005239702.1] [location=complement(367... ENVZ_SALTY - Osmolarity sensor protein EnvZ OS=Salmonella typhimurium GN=envZ PE=3 SV=2	277.0	[0..1]	[450..1]
ENVZ_SALTI - Osmolarity sensor protein envZ OS=Salmonella typhi GN=envZ PE=3 SV=2 gi\|29144273, gi\|... - gi\|29144273\|ref\|NP_807615.1\| osmolarity sensor protein [Salmonella enterica subsp. enterica serovar ... gi\|16762786 - gi\|16762786\|ref\|NP_458403.1\| osmolarity sensor protein [Salmonella enterica subsp. enterica serovar ... ENVZ_SALTI - Osmolarity sensor protein EnvZ OS=Salmonella typhi GN=envZ PE=3 SV=2	277.0	[0..1]	[450..1]
gi\|26110433, gi\|... - gi\|26250004\|ref\|NP_756044.1\| osmolarity sensor protein [Escherichia coli CFT073], gi\|26110433\|gb\|AAN... gi\|91212878, gi\|... - gi\|91212878\|ref\|YP_542864.1\| osmolarity sensor protein [Escherichia coli UTI89], gi\|91074452\|gb\|ABE0... gi\|115514795, gi... - gi\|117625671\|ref\|YP_858994.1\| osmolarity sensor protein [Escherichia coli APEC O1], gi\|115514795\|gb\|... gi\|218367231, gi... - gi\|218560462\|ref\|YP_002393375.1\| osmolarity sensor protein [Escherichia coli S88], gi\|218367231\|emb\|... gi\|226902398, gi... - gi\|237703134\|ref\|ZP_04533615.1\| osmolarity sensor protein envZ [Escherichia sp. 3_2_53FAA], gi\|22690... gi\|170518903, gi... - gi\|170681185\|ref\|YP_001745652.1\| osmolarity sensor protein EnvZ [Escherichia coli SMS-3-5], gi\|17051... gi\|215266757, gi... - gi\|215488685\|ref\|YP_002331116.1\| osmolarity sensor protein [Escherichia coli O127:H6 str. E2348/69],... gi\|227883538, gi... - gi\|227883538\|ref\|ZP_04001343.1\| sensory histidine kinase in two-component regulatory system with Omp...	277.0	[0..1]	[450..1]
gi\|541207 - gi\|541207\|pir\|\|S41888 envZ protein - Salmonella typhi	276.0	[0..1]	[450..1]

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Predicted Domain #1

Region A:
Residues: [1-148]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRLRFSPRS SFARTLLLIV TLLFASLVTT YLVVLNFAIL PSLQQFNKVL AYEVRMLMTD  60
   61 KLQLEDGTQL VVPPAFRREI YRELGISLYS NEAAEEAGLR WAQHYEFLSH QMAQQLGGPT 120
  121 EVRVEVNKSS PVVWLKTWLS PNIWVRVP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [149-270]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTEIHQGDFS PLFRYTLAIM LLAIGGAWLF IRIQNRPLVD LEHAALQVGK GIIPPPLREY  60
   61 GASEVRSVTR AFNHMAAGVK QLADDRTLLM AGVSHDLRTP LTRIRLATEM MSEQDGYLAE 120
  121 SI

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.34
Match:	2f95B
Description:	M intermediate structure of sensory rhodopsin II/transducer complex in combination with the ground state structure
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [271-450]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKDIEECNAI IEQFIDYLRT GQEMPMEMAD LNAVLGEVIA AESGYEREIE TALYPGSIEV  60
   61 KMHPLSIKRA VANMVVNAAR YGNGWIKVSS GTEPNRAWFQ VEDDGPGIAP EQRKHLFQPF 120
  121 VRGDSARTIS GTGLGLAIVQ RIVDNHNGML ELGTSERGGL SIRAWLPVPV TRAQGTTKEG 180
  181

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.30103
Match:	1bxdA
Description:	Histidine kinase domain of the osmosensor EnvZ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein histidine kinase activity	4.82398483954378	bayes_pls_golite062009
two-component sensor activity	4.79766298875975	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	4.76164614213074	bayes_pls_golite062009
two-component response regulator activity	3.47298917518553	bayes_pls_golite062009
signal transducer activity	2.91676094682887	bayes_pls_golite062009
molecular transducer activity	2.91676094682887	bayes_pls_golite062009
protein kinase activity	2.34507002285329	bayes_pls_golite062009
kinase activity	2.18775056477858	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.17409873880782	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.98933866931605	bayes_pls_golite062009
transferase activity	1.07472897478108	bayes_pls_golite062009
catalytic activity	0.812403102604677	bayes_pls_golite062009
binding	0.162154598845105	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: