YRC Public Data Repository - Protein Structure Prediction

Protein:	EMRA_ECOLI
Organism:	Escherichia coli
Length:	390 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EMRA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|11350621 - pir\|\|D83002 multidrug resistance protein PA5159 [imported] - Pseudomonas aeruginosa (strain PAO1) gi\|9951460, gi\|1... - gi\|9951460\|gb\|AAG08544.1\|AE004928_10 multidrug resistance protein [Pseudomonas aeruginosa PAO1], gi\|...	263.0	[0..7]	[390..2]
gi\|3414725 - gi\|3414725\|gb\|AAC31387.1\| multidrug resistance efflux pump homolog PmrA [Pseudomonas aeruginosa] gi\|3414725\|gb\|AA... - multidrug resistance efflux pump homolog PmrA [Pseudomonas aeruginosa]	262.0	[0..7]	[390..2]
gi\|26990261, gi\|... - gi\|26990261\|ref\|NP_745686.1\| secretion protein HlyD family protein [Pseudomonas putida KT2440], gi\|2...	258.0	[0..1]	[390..1]
gi\|82735650, gi\|... - gi\|82735650\|ref\|ZP_00898512.1\| multidrug efflux MFS membrane fusion protein [Pseudomonas putida F1],... tr\|I7B9T7\|I7B9T7... - Secretion protein HlyD family protein OS=Pseudomonas putida (strain DOT-T1E) GN=emrA PE=4 SV=1	257.0	[0..1]	[390..1]
gi\|150959430, gi... - gi\|94417635\|ref\|ZP_01297452.1\| hypothetical protein PaerP_01000412 [Pseudomonas aeruginosa PA7], gi\|...	254.0	[0..3]	[390..4]
gi\|107104259 - gi\|107104259\|ref\|ZP_01368177.1\| hypothetical protein PaerPA_01005333 [Pseudomonas aeruginosa PACS2]	253.0	[0..3]	[390..4]
gi\|84323921 - gi\|84323921\|ref\|ZP_00971987.1\| COG1566: Multidrug resistance efflux pump [Pseudomonas aeruginosa 219...	253.0	[0..3]	[390..4]
gi\|46445762, gi\|... - gi\|46445762\|ref\|YP_007127.1\| multidrug resistance protein, emrA [Candidatus Protochlamydia amoebophi...	253.0	[0..2]	[388..8]
gi\|28854152, gi\|... - gi\|28870903\|ref\|NP_793522.1\| multidrug resistance protein [Pseudomonas syringae pv. tomato str. DC30... tr\|Q87YP7\|Q87YP7... - Multidrug resistance protein OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=PSPTO_3748 PE=4 S...	251.0	[0..2]	[390..5]
gi\|71557643, gi\|... - gi\|71737090\|ref\|YP_275702.1\| multidrug resistance protein [Pseudomonas syringae pv. phaseolicola 144...	251.0	[0..2]	[390..5]

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Predicted Domain #1

Region A:
Residues: [1-390]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSANAETQTP QQPVKKSGKR KRLLLLLTLL FIIIAVAIGI YWFLVLRHFE ETDDAYVAGN  60
   61 QIQIMSQVSG SVTKVWADNT DFVKEGDVLV TLDPTDARQA FEKAKTALAS SVRQTHQLMI 120
  121 NSKQLQANIE VQKIALAKAQ SDYNRRVPLG NANLIGREEL QHARDAVTSA QAQLDVAIQQ 180
  181 YNANQAMILG TKLEDQPAVQ QAATEVRNAW LALERTRIIS PMTGYVSRRA VQPGAQISPT 240
  241 TPLMAVVPAT NMWVDANFKE TQIANMRIGQ PVTITTDIYG DDVKYTGKVV GLDMGTGSAF 300
  301 SLLPAQNATG NWIKVVQRLP VRIELDQKQL EQYPLRIGLS TLVSVNTTNR DGQVLANKVR 360
  361 STPVAVSTAR EISLAPVNKL IDDIVKANAG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	29.221849
Match:	1t5eA
Description:	The structure of MexA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
drug transmembrane transporter activity	6.72943251269963	bayes_pls_golite062009
	6.35210689530056	bayes_pls_golite062009
	6.27508108329198	bayes_pls_golite062009
transporter activity	4.64829294279324	bayes_pls_golite062009
transmembrane transporter activity	3.3430410220484	bayes_pls_golite062009
protein transporter activity	2.78337364594901	bayes_pls_golite062009
substrate-specific transporter activity	2.32388774487807	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.892013812755237	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.729251657794536	bayes_pls_golite062009
ion transmembrane transporter activity	0.696350598512404	bayes_pls_golite062009
cation transmembrane transporter activity	0.560994844134224	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: