YRC Public Data Repository - Protein Structure Prediction

Protein:	EBGR_ECOLI
Organism:	Escherichia coli
Length:	327 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EBGR_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|20515183, gi\|... - gi\|20806727\|ref\|NP_621898.1\| transcriptional regulator [Thermoanaerobacter tengcongensis MB4], gi\|20... gi\|20806727 - gi\|20806727\|ref\|NP_621898.1\| Transcriptional regulator [Thermoanaerobacter tengcongensis MB4] gi\|254478068, gi... - gi\|254478068\|ref\|ZP_05091451.1\| Periplasmic binding proteins and sugar binding domain of the LacI fa...	352.0	[0..2]	[327..3]
gi\|167038831, gi... - gi\|167038831\|ref\|YP_001661816.1\| periplasmic binding protein/LacI transcriptional regulator [Thermoa... gi\|242258204, gi... - gi\|242258204\|ref\|ZP_04803030.1\| transcriptional regulator, LacI family [Thermoanaerobacter sp. X513]...	352.0	[0..2]	[327..3]
gi\|76797419, gi\|... - gi\|76797419\|ref\|ZP_00779738.1\| regulatory protein, LacI:Periplasmic binding protein/LacI transcripti... gi\|241882990, gi... - gi\|241904637\|ref\|ZP_04789316.1\| transcriptional regulator, LacI family [Thermoanaerobacter brockii s...	340.0	[0..2]	[327..3]
gi\|89209818, gi\|... - gi\|89209818\|ref\|ZP_01188212.1\| regulatory protein, LacI:Periplasmic binding protein/LacI transcripti...	336.0	[0..2]	[326..3]
gi\|51891908, gi\|... - gi\|51891908\|ref\|YP_074599.1\| LacI family transcriptional repressor [Symbiobacterium thermophilum IAM...	330.0	[0..3]	[327..2]
gi\|82401152, gi\|... - gi\|82500860\|ref\|ZP_00886253.1\| regulatory protein, LacI [Caldicellulosiruptor saccharolyticus DSM 89...	327.0	[0..2]	[326..12]

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Predicted Domain #1

Region A:
Residues: [1-327]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATLKDIAIE AGVSLATVSR VLNDDPTLNV KEETKHRILE IAEKLEYKTS SARKLQTGAV  60
   61 NQHHILAIYS YQQELEINDP YYLAIRHGIE TQCEKLGIEL TNCYEHSGLP DIKNVTGILI 120
  121 VGKPTPALRA AASALTDNIC FIDFHEPGSG YDAVDIDLAR ISKEIIDFYI NQGVNRIGFI 180
  181 GGEDEPGKAD IREVAFAEYG RLKQVVREED IWRGGFSSSS GYELAKQMLA REDYPKALFV 240
  241 ASDSIAIGVL RAIHERGLNI PQDISLISVN DIPTARFTFP PLSTVRIHSE MMGSQGVNLV 300
  301 YEKARDGRAL PLLVFVPSKL KLRGTTR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	85.0
Match:	1zvvA
Description:	Crystal structure of a ccpa-crh-dna complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.03730517010624	bayes_pls_golite062009
DNA binding	2.13752511265098	bayes_pls_golite062009
transcription factor activity	2.10452652023643	bayes_pls_golite062009
nucleic acid binding	2.05471649974481	bayes_pls_golite062009
binding	1.58080550382179	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.29966985317584	bayes_pls_golite062009
sequence-specific DNA binding	0.20324889750334	bayes_pls_golite062009
signal transducer activity	0.11302624216037	bayes_pls_golite062009
molecular transducer activity	0.11302624216037	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: