YRC Public Data Repository - Protein Structure Prediction

Protein:	DICA_ECOLI
Organism:	Escherichia coli
Length:	135 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DICA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|119373896, gi... - gi\|69935879\|ref\|ZP_00630766.1\| Helix-turn-helix motif [Paracoccus denitrificans PD1222], gi\|69152812...	100.0	[0..1]	[114..1]
gi\|91191378, gi\|... - gi\|91223886\|ref\|ZP_01259150.1\| putative transcriptional regulator [Vibrio alginolyticus 12G01], gi\|9...	98.0	[0..3]	[132..1]
gi\|254792733, gi... - gi\|254792733\|ref\|YP_003077570.1\| DicA-like protein, regulator of DicB [Escherichia coli O157:H7 str.... gi\|218431640, gi... - gi\|218704543\|ref\|YP_002412062.1\| transcriptional repressor DicA [Escherichia coli UMN026], gi\|218431... gi\|25301360, gi\|... - pir\|\|D85707 probable regulatory protein [imported] - Escherichia coli (strain O157:H7, substrain ED... gi\|218351187, gi... - gi\|218694455\|ref\|YP_002402122.1\| transcriptional repressor DicA [Escherichia coli 55989], gi\|2183511... gi\|15831019, gi\|... - gi\|15831019\|ref\|NP_309792.1\| transcriptional repressor DicA [Escherichia coli O157:H7 str. Sakai], g... gi\|208814889, gi... - gi\|208814889\|ref\|ZP_03256068.1\| HTH-type transcriptional regulator DicA [Escherichia coli O157:H7 st... gi\|12514990, gi\|... - gi\|15801491\|ref\|NP_287508.1\| transcriptional repressor DicA [Escherichia coli O157:H7 EDL933], gi\|12... gi\|15831019, gi\|... - gi\|15831019\|ref\|NP_309792.1\| putative regulatory protein [Escherichia coli O157:H7], gi\|13361230\|dbj...	97.0	[0..3]	[135..1]
gi\|24051146, gi\|... - gi\|24112291\|ref\|NP_706801.1\| transcriptional repressor DicA [Shigella flexneri 2a str. 301], gi\|2405...	96.0	[0..3]	[135..1]
gi\|28806770 - gi\|28806770\|dbj\|BAC60041.1\| putative transcriptional regulator [Vibrio parahaemolyticus RIMD 2210633... gi\|28898552, gi\|... - gi\|28898552\|ref\|NP_798157.1\| DNA-binding transcriptional repressor PuuR [Vibrio parahaemolyticus RIM... gi\|153836272, gi... - gi\|153836272\|ref\|ZP_01988939.1\| HTH-type transcriptional regulator PuuR [Vibrio parahaemolyticus AQ3...	96.0	[0..3]	[132..1]
gi\|56697146, gi\|... - gi\|56697146\|ref\|YP_167509.1\| DNA-binding protein, putative [Ruegeria pomeroyi DSS-3], gi\|56678883\|gb...	94.0	[0..1]	[115..1]
gi\|126102978, gi... - gi\|126461314\|ref\|YP_001042428.1\| XRE family transcriptional regulator [Rhodobacter sphaeroides ATCC ... gi\|83360216, gi\|... - gi\|83370069\|ref\|ZP_00914915.1\| Helix-turn-helix motif [Rhodobacter sphaeroides ATCC 17025], gi\|83360... gi\|77386855, gi\|... - gi\|77462437\|ref\|YP_351941.1\| XRE family transcriptional regulator [Rhodobacter sphaeroides 2.4.1], g...	93.0	[0..5]	[116..6]
gi\|78365654, gi\|... - gi\|78365654\|ref\|ZP_00835939.1\| Helix-turn-helix motif:Cupin region [Shewanella sp. PV-4], gi\|7836219...	93.0	[0..6]	[133..1]
gi\|109455404, gi... - gi\|110679288\|ref\|YP_682295.1\| Cro/CI family transcriptional regulator putative [Roseobacter denitrif...	92.0	[0..5]	[114..6]

Back

Predicted Domain #1

Region A:
Residues: [1-135]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METKNLTIGE RIRYRRKNLK HTQRSLAKAL KISHVSVSQW ERGDSEPTGK NLFALSKVLQ  60
   61 CSPTWILFGD EDKQPTPPVE KPVALSPKEL ELLELFNALP ESEQDTQLAE MRARVKNFNK 120
  121 LFEELLKARQ RTNKR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.69897
Match:	1adrA
Description:	DETERMINATION OF THE NUCLEAR MAGNETIC RESONANCE STRUCTURE OF THE DNA-BINDING DOMAIN OF THE P22 C2 REPRESSOR (1-76) IN SOLUTION AND COMPARISON WITH THE DNA-BINDING DOMAIN OF THE 434 REPRESSOR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA binding	3.60509310049517	bayes_pls_golite062009
transcription regulator activity	3.48897156115814	bayes_pls_golite062009
nucleic acid binding	3.34114111237501	bayes_pls_golite062009
binding	2.84855827811506	bayes_pls_golite062009
transcription factor activity	2.15956406789231	bayes_pls_golite062009
catalytic activity	0.374904657353081	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.29966985317584	bayes_pls_golite062009
sequence-specific DNA binding	0.11459677079129	bayes_pls_golite062009
transcription repressor activity	0.0485771867742395	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: