YRC Public Data Repository - Protein Structure Prediction

Protein:	DEGQ_ECOLI
Organism:	Escherichia coli
Length:	455 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DEGQ_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|81246948, gi\|... - gi\|82545537\|ref\|YP_409484.1\| serine endoprotease [Shigella boydii Sb227], gi\|81246948\|gb\|ABB67656.1\|...	388.0	[0..1]	[455..1]
gi\|227887949, gi... - gi\|227887949\|ref\|ZP_04005754.1\| serine endoprotease [Escherichia coli 83972], gi\|227835345\|gb\|EEJ458... gi\|75237911, gi\|... - gi\|75237911\|ref\|ZP_00721922.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|218560296, gi... - gi\|218560296\|ref\|YP_002393209.1\| serine endoprotease [Escherichia coli S88], gi\|218367065\|emb\|CAR048... gi\|117625518, gi... - gi\|117625518\|ref\|YP_858841.1\| serine endoprotease [Escherichia coli APEC O1], gi\|115514642\|gb\|ABJ027...	388.0	[0..1]	[455..1]
gi\|226899060, gi... - gi\|237706020\|ref\|ZP_04536501.1\| serine endoprotease DegQ [Escherichia sp. 3_2_53FAA], gi\|226899060\|g... gi\|26110243, gi\|... - gi\|26249815\|ref\|NP_755855.1\| serine endoprotease [Escherichia coli CFT073], gi\|26110243\|gb\|AAN82429.... gi\|91074228, gi\|... - gi\|91212654\|ref\|YP_542640.1\| serine endoprotease [Escherichia coli UTI89], gi\|91074228\|gb\|ABE09109.1...	387.0	[0..1]	[455..15]
gi\|170519768, gi... - gi\|170682050\|ref\|YP_001745506.1\| serine peptidase DegQ [Escherichia coli SMS-3-5], gi\|170519768\|gb\|A... gi\|82778542, gi\|... - gi\|82778542\|ref\|YP_404891.1\| serine endoprotease [Shigella dysenteriae Sd197], gi\|81242690\|gb\|ABB634...	387.0	[0..1]	[455..1]
gi\|110807096, gi... - gi\|110807096\|ref\|YP_690616.1\| serine endoprotease [Shigella flexneri 5 str. 8401], gi\|110616644\|gb\|A...	387.0	[0..1]	[455..1]
gi\|167426999, gi... - gi\|167426999\|ref\|ZP_02318752.1\| protease DegQ [Yersinia pestis biovar Mediaevalis str. K1973002], gi... gi\|166961394, gi... - gi\|167420588\|ref\|ZP_02312341.1\| protease DegQ [Yersinia pestis biovar Orientalis str. MG05-1020], gi... gi\|167049917, gi... - gi\|167400549\|ref\|ZP_02306058.1\| protease DegQ [Yersinia pestis biovar Antiqua str. UG05-0454], gi\|16... gi\|166211981, gi... - gi\|166211981\|ref\|ZP_02238016.1\| protease DegQ [Yersinia pestis biovar Antiqua str. B42003004], gi\|16... gi\|166011389, gi... - gi\|166011389\|ref\|ZP_02232287.1\| protease DegQ [Yersinia pestis biovar Antiqua str. E1979001], gi\|165... gi\|165914624, gi... - gi\|165937519\|ref\|ZP_02226082.1\| protease DegQ [Yersinia pestis biovar Orientalis str. IP275], gi\|165... gi\|165928145, gi... - gi\|165928145\|ref\|ZP_02223977.1\| protease DegQ [Yersinia pestis biovar Orientalis str. F1991016], gi\|... gi\|21956804, gi\|... - gi\|22124057\|ref\|NP_667480.1\| protease [Yersinia pestis KIM], gi\|21956804\|gb\|AAM83731.1\|AE013614_5 se... gi\|162354300, gi... - gi\|162421485\|ref\|YP_001605683.1\| protease [Yersinia pestis Angola], gi\|162354300\|gb\|ABX88248.1\| prot...	386.0	[0..1]	[455..7]
gi\|153949437, gi... - gi\|153949437\|ref\|YP_001399449.1\| protease DegQ [Yersinia pseudotuberculosis IP 31758], gi\|152960932\|... gi\|145209343, gi... - gi\|145597647\|ref\|YP_001161723.1\| protease [Yersinia pestis Pestoides F], gi\|145209343\|gb\|ABP38750.1\|... gi\|229695588, gi... - gi\|229839222\|ref\|ZP_04459381.1\| protease [Yersinia pestis biovar Orientalis str. PEXU2], gi\|22969558... gi\|229837073, gi... - gi\|229837073\|ref\|ZP_04457238.1\| protease [Yersinia pestis Pestoides A], gi\|229706016\|gb\|EEO92025.1\| ... gi\|229687279, gi... - gi\|229899787\|ref\|ZP_04514928.1\| protease [Yersinia pestis biovar Orientalis str. India 195], gi\|2296... gi\|149288978, gi... - gi\|153997341\|ref\|ZP_02022441.1\| protease [Yersinia pestis CA88-4125], gi\|149288978\|gb\|EDM39058.1\| pr... gi\|25305539 - pir\|\|AG0433 proteinase (EC 3.4.21.-) [imported] - Yersinia pestis (strain CO92) gi\|51591085, gi\|... - gi\|51597803\|ref\|YP_071994.1\| protease [Yersinia pseudotuberculosis IP 32953], gi\|51591085\|emb\|CAH227... Q665K6\|Q665K6_YERPS - Protease precursor - Yersinia pseudotuberculosis gi\|45438421, gi\|... - gi\|45443552\|ref\|NP_995091.1\| protease [Yersinia pestis biovar Microtus str. 91001], gi\|45438421\|gb\|A... gi\|115349189, gi... - gi\|218930578\|ref\|YP_002348453.1\| protease [Yersinia pestis CO92], gi\|16123710\|ref\|NP_407023.1\| prote... gi\|108813608, gi... - gi\|229904102\|ref\|ZP_04519213.1\| protease [Yersinia pestis Nepal516], gi\|229678220\|gb\|EEO74325.1\| pro... gi\|108809728, gi... - gi\|108809728\|ref\|YP_653644.1\| protease [Yersinia pestis Antiqua], gi\|108781641\|gb\|ABG15699.1\| protea... gi\|186896995, gi... - gi\|186896995\|ref\|YP_001874107.1\| protease Do [Yersinia pseudotuberculosis PB1/+], gi\|186700021\|gb\|AC... gi\|169749305, gi... - gi\|170022771\|ref\|YP_001719276.1\| protease Do [Yersinia pseudotuberculosis YPIII], gi\|169749305\|gb\|AC... gi\|167470720 - gi\|167470720\|ref\|ZP_02335424.1\| protease DegQ [Yersinia pestis FV-1]	386.0	[0..1]	[455..1]
gi\|208726827, gi... - gi\|208807026\|ref\|ZP_03249363.1\| serine peptidase DegQ [Escherichia coli O157:H7 str. EC4206], gi\|208... gi\|13363580, gi\|... - gi\|15833361\|ref\|NP_312134.1\| serine endoprotease [Escherichia coli O157:H7 str. Sakai], gi\|13363580\|... gi\|195939430 - gi\|195939430\|ref\|ZP_03084812.1\| serine endoprotease [Escherichia coli O157:H7 str. EC4024] gi\|168800945, gi... - gi\|189376842\|gb\|EDU95258.1\| serine peptidase DegQ [Escherichia coli O157:H7 str. EC508], gi\|16880094... gi\|189374104, gi... - gi\|189374104\|gb\|EDU92520.1\| serine peptidase DegQ [Escherichia coli O157:H7 str. EC869], gi\|16878611... gi\|217327093, gi... - gi\|217327093\|ref\|ZP_03443176.1\| serine peptidase DegQ [Escherichia coli O157:H7 str. TW14588], gi\|21... gi\|209399719, gi... - gi\|209399719\|ref\|YP_002272697.1\| serine peptidase DegQ [Escherichia coli O157:H7 str. EC4115], gi\|20... gi\|208741708, gi... - gi\|208821585\|ref\|ZP_03261905.1\| serine peptidase DegQ [Escherichia coli O157:H7 str. EC4042], gi\|208... gi\|208733346, gi... - gi\|208812069\|ref\|ZP_03253398.1\| serine peptidase DegQ [Escherichia coli O157:H7 str. EC4045], gi\|208... gi\|13363580, gi\|... - gi\|15833361\|ref\|NP_312134.1\| serine endoprotease [Escherichia coli O157:H7], gi\|13363580\|dbj\|BAB3753... gi\|168754214, gi... - gi\|189358656\|gb\|EDU77075.1\| serine peptidase DegQ [Escherichia coli O157:H7 str. EC4401], gi\|1687542... gi\|209757780, gi... - pir\|\|C91142 serine endoproteinase [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509... gi\|189000984, gi... - gi\|189000984\|gb\|EDU69970.1\| serine peptidase DegQ [Escherichia coli O157:H7 str. EC4076], gi\|1687813... gi\|254795177, gi... - gi\|254795177\|ref\|YP_003080014.1\| serine endoprotease, periplasmic [Escherichia coli O157:H7 str. TW1... gi\|187767163, gi... - gi\|187767163\|gb\|EDU31007.1\| serine peptidase DegQ [Escherichia coli O157:H7 str. EC4196], gi\|1687776... gi\|168769088, gi... - gi\|189361824\|gb\|EDU80243.1\| serine peptidase DegQ [Escherichia coli O157:H7 str. EC4486], gi\|1687690... gi\|168763769, gi... - gi\|189366157\|gb\|EDU84573.1\| serine peptidase DegQ [Escherichia coli O157:H7 str. EC4501], gi\|1687637...	385.0	[0..1]	[455..1]
gi\|192926984, gi... - gi\|75256604\|ref\|ZP_00728234.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai...	385.0	[0..1]	[455..1]
gi\|73857241, gi\|... - gi\|74313764\|ref\|YP_312183.1\| serine endoprotease [Shigella sonnei Ss046], gi\|73857241\|gb\|AAZ89948.1\|...	385.0	[0..1]	[455..1]

Back

Predicted Domain #1

Region A:
Residues: [1-455]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKQTQLLSA LALSVGLTLS ASFQAVASIP GQVADQAPLP SLAPMLEKVL PAVVSVRVEG  60
   61 TASQGQKIPE EFKKFFGDDL PDQPAQPFEG LGSGVIINAS KGYVLTNNHV INQAQKISIQ 120
  121 LNDGREFDAK LIGSDDQSDI ALLQIQNPSK LTQIAIADSD KLRVGDFAVA VGNPFGLGQT 180
  181 ATSGIVSALG RSGLNLEGLE NFIQTDASIN RGNSGGALLN LNGELIGINT AILAPGGGSV 240
  241 GIGFAIPSNM ARTLAQQLID FGEIKRGLLG IKGTEMSADI AKAFNLDVQR GAFVSEVLPG 300
  301 SGSAKAGVKA GDIITSLNGK PLNSFAELRS RIATTEPGTK VKLGLLRNGK PLEVEVTLDT 360
  361 STSSSASAEM ITPALEGATL SDGQLKDGGK GIKIDEVVKG SPAAQAGLQK DDVIIGVNRD 420
  421 RVNSIAEMRK VLAAKPAIIA LQIVRGNESI YLLMR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.30103
Match:	1ky9A
Description:	Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	2.10639523340529	bayes_pls_golite062009
hydrolase activity	1.95262287761731	bayes_pls_golite062009
binding	1.92577219161709	bayes_pls_golite062009
peptidase activity	0.892956033345508	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.644798716305534	bayes_pls_golite062009
endopeptidase activity	0.323781287331288	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: