YRC Public Data Repository - Protein Structure Prediction

Protein:	CREC_ECOLI
Organism:	Escherichia coli
Length:	474 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CREC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|20808918 - gi\|20808918\|ref\|NP_624089.1\| Sensory transduction histidine kinase [Thermoanaerobacter tengcongensis... gi\|20808918, gi\|... - gi\|20808918\|ref\|NP_624089.1\| sensory transduction histidine kinase [Thermoanaerobacter tengcongensis...	304.0	[0..2]	[471..5]
gi\|187427389, gi... - gi\|75176000\|ref\|ZP_00696179.1\| COG0642: Signal transduction histidine kinase [Shigella boydii BS512]...	292.0	[0..1]	[474..1]
gi\|147251 - gi\|147251\|gb\|AAA24375.1\| phoM [Escherichia coli] tr\|A0A0G3HUI7\|A0... - Sensory histidine kinase OS=Escherichia coli (strain K12) GN=creC PE=4 SV=1	292.0	[0..1]	[474..1]
gi\|115515883, gi... - gi\|117626759\|ref\|YP_860082.1\| sensory histidine kinase CreC [Escherichia coli APEC O1], gi\|115515883... gi\|26251292, gi\|... - gi\|26251292\|ref\|NP_757332.1\| sensory histidine kinase CreC [Escherichia coli CFT073], gi\|26111725\|gb... gi\|91075691, gi\|... - gi\|91214117\|ref\|YP_544103.1\| sensory histidine kinase CreC [Escherichia coli UTI89], gi\|91075691\|gb\|... gi\|227885109, gi... - gi\|227885109\|ref\|ZP_04002914.1\| sensory histidine kinase CreC [Escherichia coli 83972], gi\|227837938... gi\|218368401, gi... - gi\|218561632\|ref\|YP_002394545.1\| sensory histidine kinase CreC [Escherichia coli S88], gi\|218368401\|... gi\|237704135, gi... - gi\|237704135\|ref\|ZP_04534616.1\| sensory histidine kinase CreC [Escherichia sp. 3_2_53FAA], gi\|226902...	291.0	[0..1]	[474..1]
gi\|73858310, gi\|... - gi\|74314833\|ref\|YP_313252.1\| sensory histidine kinase CreC [Shigella sonnei Ss046], gi\|73858310\|gb\|A...	290.0	[0..1]	[474..1]
gi\|110808187, gi... - gi\|110808187\|ref\|YP_691707.1\| sensory histidine kinase CreC [Shigella flexneri 5 str. 8401], gi\|1106...	290.0	[0..1]	[474..1]
gi\|188490249, gi... - gi\|75515590\|ref\|ZP_00737747.1\| COG0642: Signal transduction histidine kinase [Escherichia coli 53638...	290.0	[0..1]	[474..1]
gi\|191167436, gi... - gi\|75229458\|ref\|ZP_00716008.1\| COG0642: Signal transduction histidine kinase [Escherichia coli B7A],... gi\|75209602, gi\|... - gi\|75209602\|ref\|ZP_00709820.1\| COG0642: Signal transduction histidine kinase [Escherichia coli B171]... gi\|157163847, gi... - gi\|75198213\|ref\|ZP_00708283.1\| COG0642: Signal transduction histidine kinase [Escherichia coli HS], ... gi\|157081318, gi... - gi\|75189107\|ref\|ZP_00702374.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E2437... gi\|218556935, gi... - gi\|218556935\|ref\|YP_002389849.1\| sensory histidine kinase CreC [Escherichia coli IAI1], gi\|218363704...	290.0	[0..1]	[474..1]
gi\|192926703, gi... - gi\|75256310\|ref\|ZP_00727982.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E22],...	290.0	[0..1]	[474..1]
gi\|191173164, gi... - gi\|75239537\|ref\|ZP_00723507.1\| COG0642: Signal transduction histidine kinase [Escherichia coli F11],... gi\|110346430, gi... - gi\|110644838\|ref\|YP_672568.1\| sensory histidine kinase CreC [Escherichia coli 536], gi\|110346430\|gb\|...	290.0	[0..1]	[474..1]

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Predicted Domain #1

Region A:
Residues: [1-168]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIGMRLLLG YFLLVAVAAW FVLAIFVKEV KPGVRRATEG TLIDTATLLA ELARPDLLSG  60
   61 DPTHGQLAQA FNQLQHRPFR ANIGGINKVR NEYHVYMTDA QGKVLFDSAN KAVGQDYSRW 120
  121 NDVWLTLRGQ YGARSTLQNP ADPESSVMYV AAPIMDGSRL IGVLSVGK

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.04
Match:	1ojgA
Description:	Sensory domain of the membraneous two-component fumarate sensor DcuS of E. Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
two-component sensor activity	2.88093868237858	bayes_pls_golite062009
protein histidine kinase activity	2.86151216540335	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.80671328721504	bayes_pls_golite062009
protein kinase activity	1.74105675066805	bayes_pls_golite062009
two-component response regulator activity	1.62873572477094	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.58981311381645	bayes_pls_golite062009
kinase activity	1.5133458700147	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.31628115739307	bayes_pls_golite062009
signal transducer activity	1.10204821596482	bayes_pls_golite062009
molecular transducer activity	1.10204821596482	bayes_pls_golite062009
catalytic activity	0.970922685016416	bayes_pls_golite062009
transferase activity	0.839270468560673	bayes_pls_golite062009
binding	0.704248066961418	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [169-231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNAAMAPVIK RSERRILWAS AILLGIALVI GAGMVWWINR SIARLTRYAD SVTDNKPVPL  60
   61 PDL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.14
Match:	2f95B
Description:	M intermediate structure of sensory rhodopsin II/transducer complex in combination with the ground state structure
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [232-474]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSSELRKLAQ ALESMRVKLE GKNYIEQYVY ALTHELKSPL AAIRGAAEIL REGPPPEVVA  60
   61 RFTDNILTQN ARMQALVETL LRQARLENRQ EVVLTAVDVA ALFRRVSEAR TVQLAEKKIT 120
  121 LHVTPTEVNV AAEPALLEQA LGNLLDNAID FTPESGCITL SAEVDQEHVT LKVLDTGSGI 180
  181 PDYALSRIFE RFYSLPRANG QKSSGLGLAF VSEVARLFNG EVTLRNVQEG GVLASLRLHR 240
  241 HFT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.045757
Match:	2c2aA
Description:	Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: