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View Structure Prediction Details

Protein: COFA_DICDI, COFB...
Organism: Dictyostelium discoideum
Length: 137 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COFA_DICDI, COFB....

Description E-value Query
Range
Subject
Range
gi|48374972 - gi|48374972|gb|AAT42170.1| putative actin depolymerizing factor [Sorghum bicolor]
170.0 [0..2] [134..329]
gi|84028521 - gi|84028521|gb|ABC49719.1| actin depolymerizing factor-like protein [Arachis hypogaea]
160.0 [0..2] [135..5]
ADF2_PETHY - Actin-depolymerizing factor 2 OS=Petunia hybrida GN=ADF2 PE=2 SV=1
159.0 [0..2] [137..5]
gi|21554405 - gi|21554405|gb|AAM63510.1| Actin-depolymerizing factor ADF-6 [Arabidopsis thaliana]
158.0 [0..3] [135..13]
gi|68166241 - gi|68166241|gb|AAY88048.1| actin depolymerizing factor [Gossypium hirsutum]
158.0 [0..2] [135..5]

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Predicted Domain #1
Region A:
Residues: [1-137]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSGIALAPN CVSTFNDLKL GRKYGGIIYR ISDDSKEIIV DSTLPAGCSF DEFTKCLPEN  60
   61 ECRYVVLDYQ YKEEGAQKSK ICFVAWCPDT ANIKKKMMAT SSKDSLRKAC VGIQVEIQGT 120
  121 DASEVKDSCF YEKCTKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.154902
Match: 1f7sA
Description: Cofilin (actin depolymerizing factor, ADF)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 7.52071741004022 bayes_pls_golite062009
cytoskeletal protein binding 6.04859625643932 bayes_pls_golite062009
actin filament binding 5.45532510538573 bayes_pls_golite062009
protein binding 2.93027234013365 bayes_pls_golite062009
binding 2.84811181543046 bayes_pls_golite062009
protein kinase activity 2.04816578082974 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.67227267699496 bayes_pls_golite062009
kinase activity 1.55883505515498 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.47782133980448 bayes_pls_golite062009
protein tyrosine kinase activity 1.4161727833926 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 1.3406661967545 bayes_pls_golite062009
molecular transducer activity 0.693981553634544 bayes_pls_golite062009
signal transducer activity 0.693981553634544 bayes_pls_golite062009
transferase activity 0.591259446255369 bayes_pls_golite062009
structural constituent of cytoskeleton 0.482954032096802 bayes_pls_golite062009
structural molecule activity 0.391701411061931 bayes_pls_golite062009
enzyme regulator activity 0.270847057375333 bayes_pls_golite062009
actin monomer binding 0.224304003054399 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle