YRC Public Data Repository - Protein Structure Prediction

Protein:	CN16_ECOLI
Organism:	Escherichia coli
Length:	647 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CN16_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|83569418 - gi\|83569418\|ref\|ZP_00920872.1\| COG0737: 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related e...	600.0	[0..1]	[647..4]
gi\|75212229 - gi\|75212229\|ref\|ZP_00712269.1\| COG0737: 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related e...	600.0	[0..1]	[647..4]
gi\|117626565, gi... - gi\|117626565\|ref\|YP_859888.1\| bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotid...	600.0	[0..1]	[647..4]
gi\|75229590 - gi\|75229590\|ref\|ZP_00716129.1\| COG0737: 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related e... gi\|75188930 - gi\|75188930\|ref\|ZP_00702197.1\| COG0737: 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related e...	600.0	[0..1]	[647..4]
gi\|75258318 - gi\|75258318\|ref\|ZP_00729749.1\| COG0737: 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related e...	600.0	[0..1]	[647..4]
gi\|75198067 - gi\|75198067\|ref\|ZP_00708137.1\| COG0737: 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related e...	599.0	[0..1]	[647..4]
gi\|75242393 - gi\|75242393\|ref\|ZP_00726155.1\| COG0737: 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related e...	599.0	[0..1]	[647..4]
gi\|75515456 - gi\|75515456\|ref\|ZP_00737613.1\| COG0737: 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related e... gi\|83586752 - gi\|83586752\|ref\|ZP_00925384.1\| COG0737: 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related e...	598.0	[0..1]	[647..4]
gi\|110644579, gi... - gi\|110644579\|ref\|YP_672309.1\| bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotid... gi\|190908877, gi... - gi\|191170653\|ref\|ZP_03032205.1\| 2',3'-cyclic-nucleotide 2'-phosphodiesterase [Escherichia coli F11],...	598.0	[0..1]	[647..1]
gi\|74314694, gi\|... - gi\|74314694\|ref\|YP_313113.1\| bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotida...	597.0	[0..1]	[647..1]

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Predicted Domain #1

Region A:
Residues: [1-647]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKFSATLLA TLIAASVNAA TVDLRIMETT DLHSNMMDFD YYKDTATEKF GLVRTASLIN  60
   61 DARNEVKNSV LVDNGDLIQG SPLADYMSAK GLKAGDIHPV YKALNTLDYT VGTLGNHEFN 120
  121 YGLDYLKNAL AGAKFPYVNA NVIDARTKQP MFTPYLIKDT EVVDKDGKKQ TLKIGYIGVV 180
  181 PPQIMGWDKA NLSGKVTVND ITETVRKYVP EMREKGADVV VVLAHSGLSA DPYKVMAENS 240
  241 VYYLSEIPGV NAIMFGHAHA VFPGKDFADI EGADIAKGTL NGVPAVMPGM WGDHLGVVDL 300
  301 QLSNDSGKWQ VTQAKAEARP IYDIANKKSL AAEDSKLVET LKADHDATRQ FVSKPIGKSA 360
  361 DNMYSYLALV QDDPTVQVVN NAQKAYVEHY IQGDPDLAKL PVLSAAAPFK VGGRKNDPAS 420
  421 YVEVEKGQLT FRNAADLYLY PNTLIVVKAS GKEVKEWLEC SAGQFNQIDP NSTKPQSLIN 480
  481 WDGFRTYNFD VIDGVNYQID VTQPARYDGE CQMINANAER IKNLTFNGKP IDPNAMFLVA 540
  541 TNNYRAYGGK FAGTGDSHIA FASPDENRSV LAAWIADESK RAGEIHPAAD NNWRLAPIAG 600
  601 DKKLDIRFET SPSDKAAAFI KEKGQYPMNK VATDDIGFAI YQVDLSK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.39794
Match:	1ushA
Description:	5'-NUCLEOTIDASE FROM E. COLI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	6.90309911517124	bayes_pls_golite062009
phosphatase activity	6.28072946025083	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.26557024307779	bayes_pls_golite062009
hydrolase activity	6.0929339222298	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.57883033400437	bayes_pls_golite062009
protein serine/threonine phosphatase activity	5.11265802430394	bayes_pls_golite062009
catalytic activity	1.39852585255405	bayes_pls_golite062009
acid phosphatase activity	0.760085320241561	bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase activity	0.598330833036731	bayes_pls_golite062009
protein binding	0.420944017984634	bayes_pls_golite062009
binding	0.212656263179037	bayes_pls_golite062009
protein kinase activity	0.0890836633759679	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0524929216559791	bayes_pls_golite062009
kinase activity	0.0430043477913548	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.39246790349923E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: