YRC Public Data Repository - Protein Structure Prediction

Protein:	CLPP_ECOLI
Organism:	Escherichia coli
Length:	207 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CLPP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77974303 - gi\|77974303\|ref\|ZP_00829844.1\| COG0740: Protease subunit of ATP-dependent Clp proteases [Yersinia fr... gi\|238710696, gi... - gi\|238751006\|ref\|ZP_04612502.1\| ATP-dependent Clp protease proteolytic subunit [Yersinia rohdei ATCC...	290.0	[0..1]	[207..1]
CLPP_YERE8 - ATP-dependent Clp protease proteolytic subunit OS=Yersinia enterocolitica serotype O:8 / biotype 1B ... CLPP_YEREN - ATP-dependent Clp protease proteolytic subunit OS=Yersinia enterocolitica GN=clpP PE=3 SV=1	290.0	[0..1]	[207..1]
gi\|62179060, gi\|... - gi\|62179060\|ref\|YP_215477.1\| ATP-dependent Clp protease proteolytic subunit [Salmonella enterica sub...	288.0	[0..1]	[207..40]
gi\|77979391 - gi\|77979391\|ref\|ZP_00834810.1\| COG0740: Protease subunit of ATP-dependent Clp proteases [Yersinia in...	287.0	[0..1]	[207..1]
gi\|162419837, gi... - gi\|77635225\|ref\|ZP_00797312.1\| COG0740: Protease subunit of ATP-dependent Clp proteases [Yersinia pe... CLPP_YERP3 - ATP-dependent Clp protease proteolytic subunit OS=Yersinia pseudotuberculosis serotype O:1b (strain ... gi\|89103165, gi\|... - gi\|89103165\|ref\|ZP_01175755.1\| COG0740: Protease subunit of ATP-dependent Clp proteases [Yersinia pe... gi\|167421692, gi... - gi\|167421692\|ref\|ZP_02313445.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Yersinia pesti... CLPP_YERPA - ATP-dependent Clp protease proteolytic subunit OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=cl... gi\|167051461, gi... - gi\|167398957\|ref\|ZP_02304481.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Yersinia pesti... CLPP_YERPN - ATP-dependent Clp protease proteolytic subunit OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=c... gi\|170025451, gi... - gi\|170025451\|ref\|YP_001721956.1\| ATP-dependent Clp protease proteolytic subunit [Yersinia pseudotube... gi\|167423463, gi... - gi\|167423463\|ref\|ZP_02315216.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Yersinia pesti... gi\|22124934, gi\|... - gi\|22124934\|ref\|NP_668357.1\| ATP-dependent Clp protease proteolytic subunit [Yersinia pestis KIM], g... gi\|186697352, gi... - gi\|186894326\|ref\|YP_001871438.1\| ATP-dependent Clp protease proteolytic subunit [Yersinia pseudotube... CLPP_YERPE - ATP-dependent Clp protease proteolytic subunit OS=Yersinia pestis GN=clpP PE=3 SV=1 CLPP_YERPS - ATP-dependent Clp protease proteolytic subunit OS=Yersinia pseudotuberculosis serotype I (strain IP3... gi\|45435480, gi\|... - gi\|45440623\|ref\|NP_992162.1\| ATP-dependent Clp protease proteolytic subunit [Yersinia pestis biovar ... CLPP_YERPS - ATP-dependent Clp protease proteolytic subunit OS=Yersinia pseudotuberculosis GN=clpP PE=3 SV=1 gi\|16123319, gi\|... - gi\|218930187\|ref\|YP_002348062.1\| ATP-dependent Clp protease proteolytic subunit [Yersinia pestis CO9... gi\|165921541, gi... - gi\|165926613\|ref\|ZP_02222445.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Yersinia pesti... gi\|166212961, gi... - gi\|166212961\|ref\|ZP_02238996.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Yersinia pesti... gi\|166010967, gi... - gi\|166010967\|ref\|ZP_02231865.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Yersinia pesti... gi\|229695127, gi... - gi\|229838761\|ref\|ZP_04458920.1\| proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine ... gi\|229701008, gi... - gi\|229896085\|ref\|ZP_04511255.1\| proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine ... gi\|229899329, gi... - gi\|229899329\|ref\|ZP_04514472.1\| proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine ... gi\|149364997, gi... - gi\|149364997\|ref\|ZP_01887032.1\| ATP-dependent Clp protease proteolytic subunit ClpP [Yersinia pestis... CLPP_YERPP - ATP-dependent Clp protease proteolytic subunit OS=Yersinia pestis (strain Pestoides F) GN=clpP PE=3 ...	287.0	[0..1]	[207..1]
CLPP_PHOLL - ATP-dependent Clp protease proteolytic subunit OS=Photorhabdus luminescens subsp. laumondii GN=clpP ... CLPP_PHOLL - ATP-dependent Clp protease proteolytic subunit OS=Photorhabdus luminescens subsp. laumondii (strain ...	286.0	[0..1]	[207..1]
gi\|238715487, gi... - gi\|77956937\|ref\|ZP_00821009.1\| COG0740: Protease subunit of ATP-dependent Clp proteases [Yersinia be...	286.0	[0..1]	[207..1]
CLPP_SALNS - ATP-dependent Clp protease proteolytic subunit OS=Salmonella newport (strain SL254) GN=clpP PE=3 SV=... gi\|195631923, gi... - gi\|195631923\|gb\|EDX50443.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Salmonella enteric... gi\|168261116, gi... - gi\|205350070\|gb\|EDZ36701.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Salmonella enteric... gi\|197289522, gi... - gi\|197289522\|gb\|EDY28885.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Salmonella enteric... CLPP_SALCH - ATP-dependent Clp protease proteolytic subunit OS=Salmonella choleraesuis GN=clpP PE=3 SV=2 CLPP_SALTI - ATP-dependent Clp protease proteolytic subunit OS=Salmonella typhi GN=clpP PE=3 SV=1 CLPP_SALEP - ATP-dependent Clp protease proteolytic subunit OS=Salmonella enteritidis PT4 (strain P125109) GN=clp... CLPP_SALTY - ATP-dependent Clp protease proteolytic subunit OS=Salmonella typhimurium GN=clpP PE=3 SV=1 CLPP_SALTY - ATP-dependent Clp protease proteolytic subunit OS=Salmonella typhimurium (strain LT2 / SGSC1412 / AT... gi\|204930575, gi... - gi\|204930575\|ref\|ZP_03221505.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Salmonella ent... CLPP_SALTY - ATP-dependent Clp protease proteolytic subunit OS=Salmonella typhimurium GN=clpP PE=3 SV=1 CLPP_SALSV - ATP-dependent Clp protease proteolytic subunit OS=Salmonella schwarzengrund (strain CVM19633) GN=clp... CLPP_SALTI - ATP-dependent Clp protease proteolytic subunit OS=Salmonella typhi GN=clpP PE=3 SV=1 CLPP_SALHS - ATP-dependent Clp protease proteolytic subunit OS=Salmonella heidelberg (strain SL476) GN=clpP PE=3 ... gi\|29142800, gi\|... - gi\|29142800\|ref\|NP_806142.1\| ATP-dependent Clp protease proteolytic subunit [Salmonella enterica sub... gi\|16759428 - gi\|16759428\|ref\|NP_455045.1\| ATP-dependent Clp protease proteolytic subunit [Salmonella enterica sub... CLPP_SALCH - ATP-dependent Clp protease proteolytic subunit OS=Salmonella choleraesuis (strain SC-B67) GN=clpP PE... gi\|213646005 - gi\|213646005\|ref\|ZP_03376058.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Salmonella ent... gi\|213425858 - gi\|213425858\|ref\|ZP_03358608.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Salmonella ent... gi\|213419494 - gi\|213419494\|ref\|ZP_03352560.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Salmonella ent... lcl\|NC_016856.1_... - [gene=clpP] [protein=ATP-dependent Clp protease proteolytic subunit] [protein_id=YP_005236144.1] [lo... gi\|213025962 - gi\|213025962\|ref\|ZP_03340409.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Salmonella ent... gi\|214001925 - gi\|214001925\|ref\|ZP_03412660.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Salmonella ent... gi\|213853068 - gi\|213853068\|ref\|ZP_03382600.1\| ATP-dependent Clp protease, proteolytic subunit ClpP [Salmonella ent... gi\|238911421 - gi\|238911421\|ref\|ZP_04655258.1\| ATP-dependent Clp protease proteolytic subunit [Salmonella enterica ... CLPP_SALCH - ATP-dependent Clp protease proteolytic subunit OS=Salmonella choleraesuis GN=clpP PE=3 SV=2	285.0	[0..1]	[207..1]
CLPP_SALPA - ATP-dependent Clp protease proteolytic subunit OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42)... CLPP_SALPK - ATP-dependent Clp protease proteolytic subunit OS=Salmonella paratyphi A (strain AKU_12601) GN=clpP ... CLPP_SALPA - ATP-dependent Clp protease proteolytic subunit OS=Salmonella paratyphi A GN=clpP PE=3 SV=1	284.0	[0..1]	[207..1]
CLPP_ERWCT - ATP-dependent Clp protease proteolytic subunit OS=Erwinia carotovora subsp. atroseptica GN=clpP PE=3... CLPP_PECAS - ATP-dependent Clp protease proteolytic subunit OS=Pectobacterium atrosepticum (strain SCRI 1043 / AT...	283.0	[0..1]	[206..1]

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Predicted Domain #1

Region A:
Residues: [1-207]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYSGERDNF APHMALVPMV IEQTSRGERS FDIYSRLLKE RVIFLTGQVE DHMANLIVAQ  60
   61 MLFLEAENPE KDIYLYINSP GGVITAGMSI YDTMQFIKPD VSTICMGQAA SMGAFLLTAG 120
  121 AKGKRFCLPN SRVMIHQPLG GYQGQATDIE IHAREILKVK GRMNELMALH TGQSLEQIER 180
  181 DTERDRFLSA PEAVEYGLVD SILTHRN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.221849
Match:	1tyfA
Description:	Clp protease, ClpP subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.46154163027498	bayes_pls_golite062009
CoA carboxylase activity	0.939626895227199	bayes_pls_golite062009
acetyl-CoA carboxylase activity	0.764444938444292	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	0.621229080200493	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.620657548610719	bayes_pls_golite062009
hydrolase activity	0.534319520590169	bayes_pls_golite062009
binding	0.367666848528835	bayes_pls_golite062009
ligase activity	0.32092496884003	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: