YRC Public Data Repository - Protein Structure Prediction

Protein:	CHEB_ECOLI
Organism:	Escherichia coli
Length:	349 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CHEB_ECOLI.

Description	E-value	Query Range	Subject Range
CHEB_ERWCT - Chemotaxis response regulator protein-glutamate methylesterase OS=Erwinia carotovora subsp. atrosept... CHEB_PECAS - Chemotaxis response regulator protein-glutamate methylesterase OS=Pectobacterium atrosepticum (strai...	315.0	[0..1]	[349..1]
CHEB_SALPA - Chemotaxis response regulator protein-glutamate methylesterase OS=Salmonella paratyphi A (strain ATC... gi\|197262842, gi... - gi\|197262842\|ref\|ZP_03162916.1\| chemotaxis response regulator protein-glutamate methylesterase CheB ... gi\|197214906, gi... - gi\|197251203\|ref\|YP_002146104.1\| chemotaxis response regulator protein-glutamate methylesterase CheB... gi\|238912506 - gi\|238912506\|ref\|ZP_04656343.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. enter... gi\|194455783, gi... - gi\|194469419\|ref\|ZP_03075403.1\| chemotaxis response regulator protein-glutamate methylesterase CheB ... gi\|205342675, gi... - gi\|205342675\|gb\|EDZ29439.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Sal... gi\|213582760 - gi\|213582760\|ref\|ZP_03364586.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. enter... lcl\|NC_016856.1_... - [gene=cheB] [protein=chemotaxis-specific methylesterase] [protein_id=YP_005237885.1] [location=compl... gi\|213426382 - gi\|213426382\|ref\|ZP_03359132.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. enter... gi\|213163282 - gi\|213163282\|ref\|ZP_03348992.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. enter... gi\|197093566, gi... - gi\|197362089\|ref\|YP_002141726.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. ente... gi\|168259804, gi... - gi\|205350818\|gb\|EDZ37449.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Sal... gi\|168234017, gi... - gi\|205331961\|gb\|EDZ18725.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Sal... gi\|205327867, gi... - gi\|205327867\|gb\|EDZ14631.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Sal... gi\|167552443, gi... - gi\|205322874\|gb\|EDZ10713.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Sal... CHEB_SALTY - Chemotaxis response regulator protein-glutamate methylesterase OS=Salmonella typhimurium GN=cheB PE=... gi\|213976912 - gi\|213976912\|ref\|ZP_03404171.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. enter... gi\|213855166 - gi\|213855166\|ref\|ZP_03383406.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. enter... gi\|213647158 - gi\|213647158\|ref\|ZP_03377211.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. enter... gi\|213613010 - gi\|213613010\|ref\|ZP_03370836.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. enter... gi\|213999611 - gi\|213999611\|ref\|ZP_03410346.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. enter... CHEB_SALPA - Chemotaxis response regulator protein-glutamate methylesterase OS=Salmonella paratyphi A GN=cheB PE=... CHEB_SALTY - Chemotaxis response regulator protein-glutamate methylesterase OS=Salmonella typhimurium GN=cheB PE=... gi\|29137069, gi\|... - gi\|29141442\|ref\|NP_804784.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. enterica... CHEB_SALTY - Chemotaxis response regulator protein-glutamate methylesterase OS=Salmonella typhimurium (strain LT2...	312.0	[0..1]	[349..1]
CHEB_SALTI - Chemotaxis response regulator protein-glutamate methylesterase OS=Salmonella typhi GN=cheB PE=3 SV=1 CHEB_SALTI - Chemotaxis response regulator protein-glutamate methylesterase OS=Salmonella typhi GN=cheB PE=3 SV=1 gi\|16760866 - gi\|16760866\|ref\|NP_456483.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. enterica...	311.0	[0..1]	[349..1]
gi\|193065466, gi... - gi\|75256491\|ref\|ZP_00728137.1\| COG2201: Chemotaxis response regulator containing a CheY-like receive... gi\|190901873, gi... - gi\|75228736\|ref\|ZP_00715349.1\| COG2201: Chemotaxis response regulator containing a CheY-like receive... gi\|75209440, gi\|... - gi\|75209440\|ref\|ZP_00709668.1\| COG2201: Chemotaxis response regulator containing a CheY-like receive... gi\|209919309, gi... - gi\|209919309\|ref\|YP_002293393.1\| chemotaxis-specific methylesterase [Escherichia coli SE11], gi\|2099... gi\|75190911, gi\|... - gi\|75190911\|ref\|ZP_00704178.1\| COG2201: Chemotaxis response regulator containing a CheY-like receive... gi\|218554471, gi... - gi\|218554471\|ref\|YP_002387384.1\| chemotaxis-specific methylesterase [Escherichia coli IAI1], gi\|2183...	311.0	[0..1]	[349..1]
CHEB_SALCH - Chemotaxis response regulator protein-glutamate methylesterase OS=Salmonella choleraesuis GN=cheB PE... gi\|206708365, gi... - gi\|207856562\|ref\|YP_002243213.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. ente... CHEB_SALCH - Chemotaxis response regulator protein-glutamate methylesterase OS=Salmonella choleraesuis GN=cheB PE... CHEB_SALCH - Chemotaxis response regulator protein-glutamate methylesterase OS=Salmonella choleraesuis (strain SC... gi\|205352379, gi... - gi\|205352379\|ref\|YP_002226180.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. ente... gi\|194406852, gi... - gi\|194448548\|ref\|YP_002045971.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. ente... gi\|194401501, gi... - gi\|194442838\|ref\|YP_002041183.1\| chemotaxis response regulator protein-glutamate methylesterase CheB... gi\|204930964, gi... - gi\|204930964\|ref\|ZP_03221790.1\| chemotaxis response regulator protein-glutamate methylesterase CheB ... gi\|199602609, gi... - gi\|200390164\|ref\|ZP_03216775.1\| chemotaxis response regulator protein-glutamate methylesterase CheB ... gi\|161362887, gi... - gi\|161613523\|ref\|YP_001587488.1\| chemotaxis-specific methylesterase [Salmonella enterica subsp. ente... gi\|195634431, gi... - gi\|195634431\|gb\|EDX52783.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Sal... gi\|205339141, gi... - gi\|205339141\|gb\|EDZ25905.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Sal...	311.0	[0..1]	[349..1]
gi\|117624034, gi... - gi\|117624034\|ref\|YP_852947.1\| chemotaxis-specific methylesterase [Escherichia coli APEC O1], gi\|1155... CHEB_ECOL5 - Chemotaxis response regulator protein-glutamate methylesterase OS=Escherichia coli O6:K15:H31 (strai... CHEB_ECOUT - Chemotaxis response regulator protein-glutamate methylesterase OS=Escherichia coli (strain UTI89 / U... gi\|218689880, gi... - gi\|218689880\|ref\|YP_002398092.1\| chemotaxis-specific methylesterase [Escherichia coli ED1a], gi\|2184... gi\|218365516, gi... - gi\|218558747\|ref\|YP_002391660.1\| chemotaxis-specific methylesterase [Escherichia coli S88], gi\|21836... gi\|191173013, gi... - gi\|75239697\|ref\|ZP_00723660.1\| COG2201: Chemotaxis response regulator containing a CheY-like receive... gi\|226900596, gi... - gi\|237705839\|ref\|ZP_04536320.1\| chemotaxis-specific methylesterase [Escherichia sp. 3_2_53FAA], gi\|2...	310.0	[0..1]	[349..1]
gi\|75235313, gi\|... - gi\|75235313\|ref\|ZP_00719539.1\| COG2201: Chemotaxis response regulator containing a CheY-like receive...	310.0	[0..1]	[349..1]
gi\|13362061, gi\|... - gi\|15831847\|ref\|NP_310620.1\| chemotaxis-specific methylesterase [Escherichia coli O157:H7 str. Sakai... CHEB_ECO57 - Chemotaxis response regulator protein-glutamate methylesterase OS=Escherichia coli O157:H7 GN=cheB P... gi\|208816980, gi... - gi\|208816980\|ref\|ZP_03258100.1\| chemotaxis response regulator protein-glutamate methylesterase CheB ... gi\|208739294, gi... - gi\|208819171\|ref\|ZP_03259491.1\| chemotaxis response regulator protein-glutamate methylesterase CheB ... gi\|254592907, gi... - gi\|254793507\|ref\|YP_003078344.1\| response regulator for chemotaxis (cheA sensor); protein methyleste... gi\|209395819, gi... - gi\|209395819\|ref\|YP_002270967.1\| chemotaxis response regulator protein-glutamate methylesterase CheB... gi\|217318153, gi... - gi\|217328806\|ref\|ZP_03444887.1\| chemotaxis response regulator protein-glutamate methylesterase CheB ... gi\|189370691, gi... - gi\|189370691\|gb\|EDU89107.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Esc... gi\|168801877, gi... - gi\|189376023\|gb\|EDU94439.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Esc... gi\|195939587 - gi\|195939587\|ref\|ZP_03084969.1\| chemotaxis-specific methylesterase [Escherichia coli O157:H7 str. EC... gi\|208810390, gi... - gi\|208810390\|ref\|ZP_03252266.1\| chemotaxis response regulator protein-glutamate methylesterase CheB ... gi\|189367344, gi... - gi\|189367344\|gb\|EDU85760.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Esc... gi\|189360257, gi... - gi\|189360257\|gb\|EDU78676.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Esc... gi\|25288891, gi\|... - pir\|\|A90953 response regulator for chemotaxis CheA sensor [imported] - Escherichia coli (strain O157... gi\|187768072, gi... - gi\|187768072\|gb\|EDU31916.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Esc... gi\|168783187, gi... - gi\|188999416\|gb\|EDU68402.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Esc... gi\|168747914, gi... - gi\|188017504\|gb\|EDU55626.1\| chemotaxis response regulator protein-glutamate methylesterase CheB [Esc...	310.0	[0..1]	[349..1]
CHEB_ECOL6 - Chemotaxis response regulator protein-glutamate methylesterase OS=Escherichia coli O6 GN=cheB PE=3 S... CHEB_ECOL6 - Chemotaxis response regulator protein-glutamate methylesterase OS=Escherichia coli O6:H1 (strain CFT... gi\|124531089, gi... - gi\|124531089\|ref\|ZP_01701474.1\| response regulator receiver modulated CheB methylesterase [Escherich... gi\|169754700, gi... - gi\|170019772\|ref\|YP_001724726.1\| chemotaxis-specific methylesterase [Escherichia coli ATCC 8739], gi... gi\|215265167, gi... - gi\|215487095\|ref\|YP_002329526.1\| chemotaxis-specific methylesterase [Escherichia coli O127:H6 str. E... gi\|218699546, gi... - gi\|218699546\|ref\|YP_002407175.1\| chemotaxis-specific methylesterase [Escherichia coli IAI39], gi\|218... gi\|218705383, gi... - gi\|218705383\|ref\|YP_002412902.1\| chemotaxis-specific methylesterase [Escherichia coli UMN026], gi\|21... CHEB_SHISS - Chemotaxis response regulator protein-glutamate methylesterase OS=Shigella sonnei (strain Ss046) GN=... gi\|227885689, gi... - gi\|227885689\|ref\|ZP_04003494.1\| chemotaxis response regulator protein-glutamate methylesterase CheB ... gi\|75513029, gi\|... - gi\|75513029\|ref\|ZP_00735491.1\| COG2201: Chemotaxis response regulator containing a CheY-like receive... gi\|242377604, gi... - gi\|251785331\|ref\|YP_002999635.1\| hypothetical protein B21_01843 [Escherichia coli BL21], gi\|24237760... gi\|157161355, gi... - gi\|75195947\|ref\|ZP_00706017.1\| COG2201: Chemotaxis response regulator containing a CheY-like receive... gi\|254288731, gi... - gi\|254288731\|ref\|YP_003054479.1\| chemotaxis-specific methylesterase [Escherichia coli BL21(DE3)], gi... gi\|254161943, gi... - gi\|254161943\|ref\|YP_003045051.1\| chemotaxis-specific methylesterase [Escherichia coli B str. REL606]...	310.0	[0..1]	[349..1]
gi\|145524 - gi\|145524\|gb\|AAA23569.1\| cheB protein [Escherichia coli]	310.0	[0..1]	[349..1]

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Predicted Domain #1

Region A:
Residues: [1-349]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKIRVLSVD DSALMRQIMT EIINSHSDME MVATAPDPLV ARDLIKKFNP DVLTLDVEMP  60
   61 RMDGLDFLEK LMRLRPMPVV MVSSLTGKGS EVTLRALELG AIDFVTKPQL GIREGMLAYN 120
  121 EMIAEKVRTA AKASLAAHKP LSAPTTLKAG PLLSSEKLIA IGASTGGTEA IRHVLQPLPL 180
  181 SSPALLITQH MPPGFTRSFA DRLNKLCQIG VKEAEDGERV LPGHAYIAPG DRHMELSRSG 240
  241 ANYQIKIHDG PAVNRHRPSV DVLFHSVAKQ AGRNAVGVIL TGMGNDGAAG MLAMRQAGAW 300
  301 TLAQNEASCV VFGMPREAIN MGGVCEVVDL SQVSQQMLAK ISAGQAIRI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	85.0
Match:	1a2oA
Description:	Methylesterase CheB, N-terminal domain; Methylesterase CheB, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein-glutamate methylesterase activity	4.76725156113043	bayes_pls_golite062009
protein methylesterase activity	4.76725156113043	bayes_pls_golite062009
protein histidine kinase activity	2.35011582062573	bayes_pls_golite062009
carboxylesterase activity	2.33136193064185	bayes_pls_golite062009
two-component sensor activity	2.32303301074957	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.28838869071567	bayes_pls_golite062009
hydrolase activity	1.38910925240185	bayes_pls_golite062009
two-component response regulator activity	1.36590668894754	bayes_pls_golite062009
binding	1.22427537074115	bayes_pls_golite062009
DNA binding	1.11037597107903	bayes_pls_golite062009
nucleic acid binding	0.93151849951839	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.880545826023013	bayes_pls_golite062009
transcription factor activity	0.62886970109503	bayes_pls_golite062009
catalytic activity	0.389119219295877	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: