YRC Public Data Repository - Protein Structure Prediction

Protein:	CAN_ECOLI
Organism:	Escherichia coli
Length:	220 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CAN_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|81239563, gi\|... - gi\|82775415\|ref\|YP_401762.1\| carbonic anhydrase [Shigella dysenteriae Sd197], gi\|81239563\|gb\|ABB6027...	275.0	[0..1]	[220..1]
gi\|82542729, gi\|... - gi\|82542729\|ref\|YP_406676.1\| carbonic anhydrase [Shigella boydii Sb227], gi\|81244140\|gb\|ABB64848.1\| ... gi\|187731778, gi... - gi\|187731778\|ref\|YP_001878933.1\| carbonic anhydrase [Shigella boydii CDC 3083-94], gi\|187428770\|gb\|A...	274.0	[0..1]	[220..1]
gi\|13359586, gi\|... - gi\|15829384\|ref\|NP_308157.1\| carbonic anhydrase [Escherichia coli O157:H7 str. Sakai], gi\|13359586\|d... gi\|25291479, gi\|... - pir\|\|B90645 probable carbonic anhdrase [imported] - Escherichia coli (strain O157:H7, substrain RIM... gi\|15799810, gi\|... - gi\|15799810\|ref\|NP_285822.1\| carbonic anhydrase [Escherichia coli O157:H7 EDL933], gi\|12512841\|gb\|AA... gi\|208739699, gi... - gi\|208819576\|ref\|ZP_03259896.1\| carbonic anhydrase [Escherichia coli O157:H7 str. EC4042], gi\|208739... gi\|13359586, gi\|... - gi\|15829384\|ref\|NP_308157.1\| putative carbonic anhdrase [Escherichia coli O157:H7], gi\|13359586\|dbj\|... gi\|209160914, gi... - gi\|209399514\|ref\|YP_002268734.1\| carbonic anhydrase [Escherichia coli O157:H7 str. EC4115], gi\|20916... gi\|217324823, gi... - gi\|217324823\|ref\|ZP_03440907.1\| carbonic anhydrase [Escherichia coli O157:H7 str. TW14588], gi\|21732... gi\|189376389, gi... - gi\|189376389\|gb\|EDU94805.1\| carbonic anhydrase [Escherichia coli O157:H7 str. EC508], gi\|168801463\|r... gi\|195938192 - gi\|195938192\|ref\|ZP_03083574.1\| carbonic anhydrase [Escherichia coli O157:H7 str. EC4024] gi\|208807227, gi... - gi\|208807227\|ref\|ZP_03249564.1\| carbonic anhydrase [Escherichia coli O157:H7 str. EC4206], gi\|208727... gi\|208813460, gi... - gi\|208813460\|ref\|ZP_03254789.1\| carbonic anhydrase [Escherichia coli O157:H7 str. EC4045], gi\|208734... gi\|168770404, gi... - gi\|189360665\|gb\|EDU79084.1\| carbonic anhydrase [Escherichia coli O157:H7 str. EC4486], gi\|168770404\|... gi\|187767815, gi... - gi\|187767815\|gb\|EDU31659.1\| carbonic anhydrase [Escherichia coli O157:H7 str. EC4196], gi\|168776836\|... gi\|189000475, gi... - gi\|189000475\|gb\|EDU69461.1\| carbonic anhydrase [Escherichia coli O157:H7 str. EC4076], gi\|168782016\|... gi\|189371071, gi... - gi\|189371071\|gb\|EDU89487.1\| carbonic anhydrase [Escherichia coli O157:H7 str. EC869], gi\|168789233\|r... gi\|168752444, gi... - gi\|188013714\|gb\|EDU51836.1\| carbonic anhydrase [Escherichia coli O157:H7 str. EC4113], gi\|168752444\|... gi\|168755737, gi... - gi\|189357028\|gb\|EDU75447.1\| carbonic anhydrase [Escherichia coli O157:H7 str. EC4401], gi\|168755737\|... gi\|168764731, gi... - gi\|189365325\|gb\|EDU83741.1\| carbonic anhydrase [Escherichia coli O157:H7 str. EC4501], gi\|168764731\|... gi\|254590661, gi... - gi\|254791261\|ref\|YP_003076098.1\| carbonic anhydrase [Escherichia coli O157:H7 str. TW14359], gi\|2545...	274.0	[0..1]	[220..1]
gi\|62178741, gi\|... - gi\|62178741\|ref\|YP_215158.1\| putative carbonic anhydrase [Salmonella enterica subsp. enterica serova... gi\|205347482, gi... - gi\|205360728\|ref\|ZP_02685949.2\| carbonate dehydratase [Salmonella enterica subsp. enterica serovar H...	272.0	[0..1]	[220..18]
gi\|26246066, gi\|... - gi\|26246066\|ref\|NP_752105.1\| carbonic anhydrase [Escherichia coli CFT073], gi\|26106463\|gb\|AAN78649.1... gi\|117622413, gi... - gi\|117622413\|ref\|YP_851326.1\| carbonic anhydrase [Escherichia coli APEC O1], gi\|115511537\|gb\|ABI9961... gi\|218557069, gi... - gi\|218557069\|ref\|YP_002389982.1\| carbonic anhydrase [Escherichia coli S88], gi\|218363838\|emb\|CAR0150... gi\|218425568, gi... - gi\|218688004\|ref\|YP_002396216.1\| carbonic anhydrase [Escherichia coli ED1a], gi\|218425568\|emb\|CAR063... gi\|110341937, gi... - gi\|110640345\|ref\|YP_668073.1\| carbonic anhydrase [Escherichia coli 536], gi\|110341937\|gb\|ABG68174.1\|... gi\|191172807, gi... - gi\|191172807\|ref\|ZP_03034344.1\| carbonic anhydrase [Escherichia coli F11], gi\|190906957\|gb\|EDV66559.... gi\|91070768, gi\|... - gi\|91209194\|ref\|YP_539180.1\| carbonic anhydrase [Escherichia coli UTI89], gi\|91070768\|gb\|ABE05649.1\|... gi\|237704282, gi... - gi\|237704282\|ref\|ZP_04534763.1\| yadF [Escherichia sp. 3_2_53FAA], gi\|226902194\|gb\|EEH88453.1\| yadF [... gi\|227838101, gi... - gi\|227884963\|ref\|ZP_04002768.1\| carbonate dehydratase [Escherichia coli 83972], gi\|227838101\|gb\|EEJ4...	271.0	[0..1]	[220..1]
gi\|255055897, gi... - gi\|255055897\|ref\|ZP_05308122.1\| Carbonate dehydratase [Pectobacterium wasabiae WPP163], gi\|254988268... gi\|50122249, gi\|... - gi\|50122249\|ref\|YP_051416.1\| carbonic anhydrase [Pectobacterium atrosepticum SCRI1043], gi\|49612775\|...	271.0	[0..1]	[213..1]
gi\|194448935, gi... - gi\|194448935\|ref\|YP_002044148.1\| carbonic anhydrase [Salmonella enterica subsp. enterica serovar Hei... gi\|238911231 - gi\|238911231\|ref\|ZP_04655068.1\| carbonic anhydrase [Salmonella enterica subsp. enterica serovar Tenn... gi\|197215082, gi... - gi\|197251379\|ref\|YP_002145170.1\| carbonate dehydratase [Salmonella enterica subsp. enterica serovar ... gi\|195632738, gi... - gi\|195632738\|gb\|EDX51192.1\| carbonate dehydratase [Salmonella enterica subsp. enterica serovar Newpo... gi\|194445260, gi... - gi\|194445260\|ref\|YP_002039406.1\| carbonate dehydratase [Salmonella enterica subsp. enterica serovar ... gi\|168230463, gi... - gi\|205335031\|gb\|EDZ21795.1\| carbonate dehydratase [Salmonella enterica subsp. enterica serovar Kentu... lcl\|NC_016856.1_... - [gene=yadF] [protein=carbonic anhydrase] [protein_id=YP_005235834.1] [location=complement(202115..20... gi\|205337446, gi... - gi\|205337446\|gb\|EDZ24210.1\| carbonate dehydratase [Salmonella enterica subsp. enterica serovar Heide... gi\|167550631, gi... - gi\|205324392\|gb\|EDZ12231.1\| carbonate dehydratase [Salmonella enterica subsp. enterica serovar Saint... gi\|167990050, gi... - gi\|205331331\|gb\|EDZ18095.1\| carbonate dehydratase [Salmonella enterica subsp. enterica serovar 4,[5]... gi\|16763561, gi\|... - gi\|16763561\|ref\|NP_459176.1\| carbonic anhydrase [Salmonella typhimurium LT2], gi\|16418673\|gb\|AAL1913... gi\|162139620 - gi\|162139620\|ref\|YP_215158.2\| carbonic anhydrase [Salmonella enterica subsp. enterica serovar Choler... gi\|206707490, gi... - gi\|207855687\|ref\|YP_002242338.1\| carbonic anhydrase [Salmonella enterica subsp. enterica serovar Ent... gi\|213053559 - gi\|213053559\|ref\|ZP_03346437.1\| carbonic anhydrase [Salmonella enterica subsp. enterica serovar Typh... gi\|200389129, gi... - gi\|200389129\|ref\|ZP_03215741.1\| carbonate dehydratase [Salmonella enterica subsp. enterica serovar V... gi\|205351512, gi... - gi\|205351512\|ref\|YP_002225313.1\| carbonic anhydrase [Salmonella enterica subsp. enterica serovar Gal... gi\|197240280, gi... - gi\|197262025\|ref\|ZP_03162099.1\| carbonate dehydratase [Salmonella enterica subsp. enterica serovar S... gi\|198245647, gi... - gi\|198245647\|ref\|YP_002214127.1\| carbonate dehydratase [Salmonella enterica subsp. enterica serovar ...	269.0	[0..1]	[220..1]
gi\|85058461, gi\|... - gi\|85058461\|ref\|YP_454163.1\| carbonic anhydrase [Sodalis glossinidius str. 'morsitans'], gi\|84778981...	269.0	[0..1]	[217..1]
gi\|14277937, gi\|... - gi\|14277937\|pdb\|1I6O\|B Chain B, Crystal Structure Of E. Coli Beta Carbonic Anhydrase (Ecca), gi\|1427...	269.0	[0..2]	[220..2]
gi\|36784287, gi\|... - gi\|37524862\|ref\|NP_928206.1\| hypothetical protein plu0867 [Photorhabdus luminescens subsp. laumondii...	269.0	[0..1]	[215..2]

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Predicted Domain #1

Region A:
Residues: [1-220]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDIDTLISN NALWSKMLVE EDPGFFEKLA QAQKPRFLWI GCSDSRVPAE RLTGLEPGEL  60
   61 FVHRNVANLV IHTDLNCLSV VQYAVDVLEV EHIIICGHYG CGGVQAAVEN PELGLINNWL 120
  121 LHIRDIWFKH SSLLGEMPQE RRLDTLCELN VMEQVYNLGH STIMQSAWKR GQKVTIHGWA 180
  181 YGIHDGLLRD LDVTATNRET LEQRYRHGIS NLKLKHANHK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.69897
Match:	1i6oA
Description:	beta-carbonic anhydrase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbonate dehydratase activity	2.96380803089124	bayes_pls_golite062009
catalytic activity	1.85658156053797	bayes_pls_golite062009
binding	1.32962036184517	bayes_pls_golite062009
carbon-oxygen lyase activity	0.678762427493332	bayes_pls_golite062009
hydro-lyase activity	0.661217808517883	bayes_pls_golite062009
lyase activity	0.656288524484184	bayes_pls_golite062009
protein binding	0.132818074687599	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: