YRC Public Data Repository - Protein Structure Prediction

Protein:	BCSC_ECOLI
Organism:	Escherichia coli
Length:	1140 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BCSC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|115514937, gi... - gi\|117625813\|ref\|YP_859136.1\| cellulose synthase subunit BcsC [Escherichia coli APEC O1], gi\|1155149... gi\|218560606, gi... - gi\|218560606\|ref\|YP_002393519.1\| cellulose synthase subunit BcsC [Escherichia coli S88], gi\|21836737... gi\|237703300, gi... - gi\|237703300\|ref\|ZP_04533781.1\| cellulose synthase subunit BcsC [Escherichia sp. 3_2_53FAA], gi\|2269... gi\|218691814, gi... - gi\|218691814\|ref\|YP_002400026.1\| cellulose synthase subunit BcsC [Escherichia coli ED1a], gi\|2184293... gi\|91213036, gi\|... - gi\|91213036\|ref\|YP_543022.1\| cellulose synthase subunit BcsC [Escherichia coli UTI89], gi\|91074610\|g...	779.0	[0..1]	[1140..18]
gi\|75188295 - gi\|75188295\|ref\|ZP_00701562.1\| COG0457: FOG: TPR repeat [Escherichia coli E24377A]	777.0	[0..1]	[1140..18]
gi\|193061654, gi... - gi\|75260185\|ref\|ZP_00731453.1\| COG0457: FOG: TPR repeat [Escherichia coli E22], gi\|193061654\|ref\|ZP_... gi\|75210075, gi\|... - gi\|75210075\|ref\|ZP_00710254.1\| COG0457: FOG: TPR repeat [Escherichia coli B171], gi\|194428684\|ref\|ZP... gi\|218556081, gi... - gi\|218556081\|ref\|YP_002388994.1\| cellulose synthase subunit BcsC [Escherichia coli IAI1], gi\|2183628...	777.0	[0..1]	[1140..18]
gi\|193068462, gi... - gi\|75237468\|ref\|ZP_00721501.1\| COG0457: FOG: TPR repeat [Escherichia coli E110019], gi\|193068462\|ref...	777.0	[0..1]	[1140..18]
gi\|227839271, gi... - gi\|227883691\|ref\|ZP_04001496.1\| cellulose synthase subunit BcsC [Escherichia coli 83972], gi\|2278392... gi\|26110593, gi\|... - gi\|26250164\|ref\|NP_756204.1\| cellulose synthase subunit BcsC [Escherichia coli CFT073], gi\|26110593\|...	777.0	[0..1]	[1140..18]
gi\|83588615, gi\|... - gi\|83588615\|ref\|ZP_00927239.1\| COG0457: FOG: TPR repeat [Escherichia coli 101-1], gi\|194435786\|ref\|Z... gi\|253979509, gi... - gi\|254290202\|ref\|YP_003055950.1\| cellulose synthase subunit [Escherichia coli BL21(DE3)], gi\|2539795... gi\|242379048, gi... - gi\|251786775\|ref\|YP_003001079.1\| hypothetical protein B21_03331 [Escherichia coli BL21], gi\|24237904... gi\|254163452, gi... - gi\|254163452\|ref\|YP_003046560.1\| cellulose synthase subunit [Escherichia coli B str. REL606], gi\|253...	777.0	[0..1]	[1140..18]
gi\|191165276, gi... - gi\|75231624\|ref\|ZP_00717982.1\| COG0457: FOG: TPR repeat [Escherichia coli B7A], gi\|191165276\|ref\|ZP_...	775.0	[0..1]	[1140..18]
gi\|75242678, gi\|... - gi\|75242678\|ref\|ZP_00726422.1\| COG0457: FOG: TPR repeat [Escherichia coli F11], gi\|191170612\|ref\|ZP_...	774.0	[0..1]	[1140..18]
gi\|170083040, gi... - gi\|170083040\|ref\|YP_001732360.1\| cellulose synthase subunit [Escherichia coli str. K-12 substr. DH10... gi\|75516009, gi\|... - gi\|75516009\|ref\|ZP_00738127.1\| COG0457: FOG: TPR repeat [Escherichia coli 53638], gi\|188494263\|ref\|Z... gi\|85676514, gi\|... - gi\|89110483\|ref\|AP_004263.1\| cellulose synthase subunit [Escherichia coli str. K-12 substr. W3110], ... sp\|P37650\|BCSC_ECOLI - Cellulose synthase operon protein C OS=Escherichia coli (strain K12) GN=bcsC PE=1 SV=3 EG12257 - cellulose synthase subunit / Oxidase involved in cellulose production, contains TPR repeats EG12257 - cellulose synthase subunit / Oxidase involved in cellulose production, contains TPR repeats	772.0	[0..1]	[1140..18]
gi\|110643777, gi... - gi\|110643777\|ref\|YP_671507.1\| cellulose synthase subunit BcsC [Escherichia coli 536], gi\|110345369\|g...	771.0	[0..1]	[1140..18]

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Predicted Domain #1

Region A:
Residues: [1-474]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPMVEAAPTA QQQLLEQVRL GEATHREDLV QQSLYRLELI DPNNPDVVAA RFRSLLRQGD  60
   61 IDGAQKQLDR LSQLAPSSNA YKSSRTTMLL STPDGRQALQ QARLQATTGH AEEAVASYNK 120
  121 LFNGAPPEGD IAVEYWSTVA KIPARRGEAI NQLKRINADA PGNTGLQNNL ALLLFSSDRR 180
  181 DEGFAVLEQM AKSNAGREGA SKIWYGQIKD MPVSDASVSA LKKYLSIFSD GDSVAAAQSQ 240
  241 LAEQQKQLAD PAFRARAQGL AAVDSGMAGK AIPELQQAVR ANPKDSEALG ALGQAYSQKG 300
  301 DRANAVANLE KALALDPHSS NNDKWNSLLK VNRYWLAIQQ GDAALKANNP DRAERLFQQA 360
  361 RNVDNTDSYA VLGLGDVAMA RKDYPAAERY YQQTLRMDSG NTNAVRGLAN IYRQQSPEKA 420
  421 EAFIASLSAS QRRSIDDIER SLQNDRLAQQ AEALENQGKW AQAAALQRQR LALD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	12.522879
Match:	2ooeA
Description:	No description for 2ooeA was found.

Predicted functions:

Term	Confidence	Notes
binding	0.02652482814057	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [475-575]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGSVWITYRL SQDLWQAGQR SQADTLMRNL AQQKSNDPEQ VYAYGLYLSG HDQDRAALAH  60
   61 INSLPRAQWN SNIQELVNRL QSDQVLETAN RLRESGKEAE A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.0
Match:	1w3bA
Description:	The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [576-844]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAMLRQQPPS TRIDLTLADW AQQRRDYTAA RAAYQNVLTR EPANADAILG LTEVDIAAGD  60
   61 KAAARSQLAK LPATDNASLN TQRRVALAQA QLGDTAAAQR TFNKLIPQAK SQPPSMESAM 120
  121 VLRDGAKFEA QAGDPTQALE TYKDAMVASG VTTTRPQDND TFTRLTRNDE KDDWLKRGVR 180
  181 SDAADLYRQQ DLNVTLEHDY WGSSGTGGYS DLKAHTTMLQ VDAPYSDGRM FFRSDFVNMN 240
  241 VGSFSTNADG KWDDNWGTCT LQDCSGNRS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.69897
Match:	1o1rA
Description:	Protein farnesyltransferase alpha-subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.344141518329695	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [845-916]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSDSGASVAV GWRNDVWSWD IGTTPMGFNV VDVVGGISYS DDIGPLGYTV NAHRRPISSS  60
   61 LLAFGGQKDS PS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [917-1140]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTGKKWGGVR ADGVGLSLSY DKGEANGVWA SLSGDQLTGK NVEDNWRVRW MTGYYYKVIN  60
   61 QNNRRVTIGL NNMIWHYDKD LSGYSLGQGG YYSPQEYLSF AIPVMWRERT ENWSWELGAS 120
  121 GSWSHSRTKT MPRYPLMNLI PTDWQEEAAR QSNDGGSSQG FGYTARALLE RRVTSNWFVG 180
  181 TAIDIQQAKD YAPSHFLLYV RYSAAGWQGD MDLPPQPLIP YADW

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: