YRC Public Data Repository - Protein Structure Prediction

Protein:	ASGX_ECOLI
Organism:	Escherichia coli
Length:	321 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ASGX_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|24051038, gi\|... - gi\|24112195\|ref\|NP_706705.1\| L-asparaginase [Shigella flexneri 2a str. 301], gi\|24051038\|gb\|AAN42412... gi\|30062311, gi\|... - gi\|30062311\|ref\|NP_836482.1\| L-asparaginase [Shigella flexneri 2a str. 2457T], gi\|30040556\|gb\|AAP162... gi\|170681222, gi... - gi\|170681222\|ref\|YP_001742933.1\| L-asparaginase [Escherichia coli SMS-3-5], gi\|170518940\|gb\|ACB17118... gi\|75512833, gi\|... - gi\|75512833\|ref\|ZP_00735325.1\| COG1446: Asparaginase [Escherichia coli 53638], gi\|188492956\|ref\|ZP_0...	419.0	[0..1]	[321..1]
gi\|157065987, gi... - gi\|75194979\|ref\|ZP_00705049.1\| COG1446: Asparaginase [Escherichia coli HS], gi\|157160307\|ref\|YP_0014...	419.0	[0..1]	[321..1]
gi\|253972806, gi... - gi\|254160905\|ref\|YP_003044013.1\| L-asparaginase [Escherichia coli B str. REL606], gi\|253972806\|gb\|AC... gi\|192928945, gi... - gi\|75257574\|ref\|ZP_00729071.1\| COG1446: Asparaginase [Escherichia coli E22], gi\|193064483\|ref\|ZP_030... gi\|218351034, gi... - gi\|218694302\|ref\|YP_002401969.1\| L-asparaginase [Escherichia coli 55989], gi\|218351034\|emb\|CAU96738.... gi\|75230676, gi\|... - gi\|75230676\|ref\|ZP_00717147.1\| COG1446: Asparaginase [Escherichia coli B7A], gi\|191166193\|ref\|ZP_030... gi\|75210576, gi\|... - gi\|75210576\|ref\|ZP_00710724.1\| COG1446: Asparaginase [Escherichia coli B171], gi\|194428244\|ref\|ZP_03... gi\|75189869, gi\|... - gi\|75189869\|ref\|ZP_00703136.1\| COG1446: Asparaginase [Escherichia coli E24377A], gi\|157155936\|ref\|YP... gi\|83586132, gi\|... - gi\|83586132\|ref\|ZP_00924769.1\| COG1446: Asparaginase [Escherichia coli 101-1], gi\|194438398\|ref\|ZP_0... gi\|209918077, gi... - gi\|209918077\|ref\|YP_002292161.1\| L-asparaginase [Escherichia coli SE11], gi\|209911336\|dbj\|BAG76410.1... gi\|218553414, gi... - gi\|218553414\|ref\|YP_002386327.1\| L-asparaginase [Escherichia coli IAI1], gi\|218360182\|emb\|CAQ97732.1... gi\|253325213, gi... - gi\|254287719\|ref\|YP_003053467.1\| L-asparaginase [Escherichia coli BL21(DE3)], gi\|253977026\|gb\|ACT426... gi\|251784347, gi... - gi\|251784347\|ref\|YP_002998651.1\| hypothetical protein B21_00812 [Escherichia coli BL21], gi\|24237662...	419.0	[0..1]	[321..1]
gi\|218364501, gi... - gi\|218557732\|ref\|YP_002390645.1\| L-asparaginase [Escherichia coli S88], gi\|218364501\|emb\|CAR02183.1\|... gi\|91209862, gi\|... - gi\|91209862\|ref\|YP_539848.1\| L-asparaginase [Escherichia coli UTI89], gi\|91071436\|gb\|ABE06317.1\| put... gi\|237707209, gi... - gi\|237707209\|ref\|ZP_04537690.1\| L-asparaginase [Escherichia sp. 3_2_53FAA], gi\|226898419\|gb\|EEH84678... gi\|115512131, gi... - gi\|117623007\|ref\|YP_851920.1\| L-asparaginase [Escherichia coli APEC O1], gi\|115512131\|gb\|ABJ00206.1\|...	418.0	[0..1]	[321..1]
gi\|192957299, gi... - gi\|75236115\|ref\|ZP_00720239.1\| COG1446: Asparaginase [Escherichia coli E110019], gi\|193069346\|ref\|ZP...	417.0	[0..1]	[321..1]
gi\|82776085, gi\|... - gi\|82776085\|ref\|YP_402432.1\| L-asparaginase [Shigella dysenteriae Sd197], gi\|81240233\|gb\|ABB60943.1\|...	417.0	[0..1]	[321..1]
gi\|26107202, gi\|... - gi\|26246803\|ref\|NP_752843.1\| L-asparaginase [Escherichia coli CFT073], gi\|26107202\|gb\|AAN79386.1\|AE0... gi\|227838960, gi... - gi\|227884208\|ref\|ZP_04002013.1\| beta-aspartyl-peptidase [Escherichia coli 83972], gi\|227838960\|gb\|EE...	416.0	[0..1]	[321..1]
gi\|15804993 - gi\|15804993\|ref\|NP_286592.1\| L-asparaginase [Escherichia coli O157:H7 EDL933]	416.0	[0..1]	[321..1]
gi\|73854850, gi\|... - gi\|74311373\|ref\|YP_309792.1\| L-asparaginase [Shigella sonnei Ss046], gi\|73854850\|gb\|AAZ87557.1\| puta...	416.0	[0..1]	[321..1]
gi\|75178380, gi\|... - gi\|75178380\|ref\|ZP_00698434.1\| COG1446: Asparaginase [Shigella boydii BS512], gi\|187730680\|ref\|YP_00...	415.0	[0..1]	[321..1]

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Predicted Domain #1

Region A:
Residues: [1-178]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKAVIAIHG GAGAISRAQM SLQQELRYIE ALSAIVETGQ KMLEAGESAL DVVTEAVRLL  60
   61 EECPLFNAGI GAVFTRDETH ELDACVMDGN TLKAGAVAGV SHLRNPVLAA RLVMEQSPHV 120
  121 MMIGEGAENF AFARGMERVS PEIFSTSLRY EQLLAARKEG ATVLDHSGAP LDEKQKMG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.09691
Match:	1jn9A
Description:	Structure of Putative Asparaginase Encoded by Escherichia coli ybiK Gene
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
asparaginase activity	3.10491949780814	bayes_pls_golite062009
asparagine synthase (glutamine-hydrolyzing) activity	2.61991450279532	bayes_pls_golite062009
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	1.99899040362632	bayes_pls_golite062009
catalytic activity	1.56707079610396	bayes_pls_golite062009
peptidase activity	1.27405104505201	bayes_pls_golite062009
endopeptidase activity	1.04371669517656	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	1.03378122370412	bayes_pls_golite062009
hydrolase activity	0.94100613918089	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	0.63543941804592	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [179-321]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVGAVALDLD GNLAAATSTG GMTNKLPGRV GDSPLVGAGC YANNASVAVS CTGTGEVFIR  60
   61 ALAAYDIAAL MDYGGLSLAE ACERVVMEKL PALGGSGGLI AIDHEGNVAL PFNTEGMYRA 120
  121 WGYAGDTPTT GIYREKGDTV ATQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.154902
Match:	1t3mB
Description:	Structure of the isoaspartyl peptidase with L-asparaginase activity from E. coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
asparaginase activity	3.10491949780814	bayes_pls_golite062009
asparagine synthase (glutamine-hydrolyzing) activity	2.61991450279532	bayes_pls_golite062009
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	1.99899040362632	bayes_pls_golite062009
catalytic activity	1.56707079610396	bayes_pls_golite062009
peptidase activity	1.27405104505201	bayes_pls_golite062009
endopeptidase activity	1.04371669517656	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	1.03378122370412	bayes_pls_golite062009
hydrolase activity	0.94100613918089	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	0.63543941804592	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: