YRC Public Data Repository - Protein Structure Prediction

Protein:	AEGA_ECOLI
Organism:	Escherichia coli
Length:	659 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AEGA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|192958397, gi... - gi\|75237789\|ref\|ZP_00721805.1\| COG0493: NADPH-dependent glutamate synthase beta chain and related ox...	525.0	[0..1]	[659..1]
gi\|110642640, gi... - gi\|110642640\|ref\|YP_670370.1\| putative oxidoreductase Fe-S binding subunit [Escherichia coli 536], g... gi\|215487769, gi... - gi\|215487769\|ref\|YP_002330200.1\| putative oxidoreductase Fe-S binding subunit [Escherichia coli O127... gi\|218428158, gi... - gi\|218690594\|ref\|YP_002398806.1\| putative oxidoreductase Fe-S binding subunit [Escherichia coli ED1a...	525.0	[0..1]	[659..1]
gi\|75257271, gi\|... - gi\|75257271\|ref\|ZP_00728795.1\| COG0493: NADPH-dependent glutamate synthase beta chain and related ox... gi\|75229210, gi\|... - gi\|75229210\|ref\|ZP_00715778.1\| COG0493: NADPH-dependent glutamate synthase beta chain and related ox... gi\|194427362, gi... - gi\|75211429\|ref\|ZP_00711519.1\| COG0493: NADPH-dependent glutamate synthase beta chain and related ox... gi\|157077121, gi... - gi\|75187212\|ref\|ZP_00700479.1\| COG0493: NADPH-dependent glutamate synthase beta chain and related ox... gi\|218361759, gi... - gi\|218554991\|ref\|YP_002387904.1\| putative oxidoreductase Fe-S binding subunit [Escherichia coli IAI1... gi\|209919940, gi... - gi\|209919940\|ref\|YP_002294024.1\| putative oxidoreductase Fe-S binding subunit [Escherichia coli SE11...	525.0	[0..1]	[659..1]
gi\|81246327, gi\|... - gi\|82544916\|ref\|YP_408863.1\| putative oxidoreductase Fe-S binding subunit [Shigella boydii Sb227], g...	525.0	[0..1]	[659..1]
gi\|81241992, gi\|... - gi\|82777844\|ref\|YP_404193.1\| putative oxidoreductase Fe-S binding subunit [Shigella dysenteriae Sd19...	524.0	[0..1]	[659..1]
gi\|191172939, gi... - gi\|75240117\|ref\|ZP_00724076.1\| COG0493: NADPH-dependent glutamate synthase beta chain and related ox...	524.0	[0..1]	[659..1]
gi\|25387633, gi\|... - pir\|\|B91045 probable oxidoreductase Fe-S subunit ECs3330 [imported] - Escherichia coli (strain O157:... gi\|209396864, gi... - gi\|209396864\|ref\|YP_002271936.1\| protein aegA [Escherichia coli O157:H7 str. EC4115], gi\|209158264\|g... gi\|217327657, gi... - gi\|217327657\|ref\|ZP_03443740.1\| protein aegA [Escherichia coli O157:H7 str. TW14588], gi\|217320024\|g... gi\|15802990, gi\|... - gi\|15802990\|ref\|NP_289020.1\| putative oxidoreductase Fe-S binding subunit [Escherichia coli O157:H7 ... gi\|15832584, gi\|... - gi\|15832584\|ref\|NP_311357.1\| putative oxidoreductase Fe-S subunit [Escherichia coli O157:H7], gi\|133... gi\|195936609 - gi\|195936609\|ref\|ZP_03081991.1\| putative oxidoreductase Fe-S binding subunit [Escherichia coli O157:... gi\|208726086, gi... - gi\|208806285\|ref\|ZP_03248622.1\| protein aegA [Escherichia coli O157:H7 str. EC4206], gi\|208726086\|gb... gi\|208813183, gi... - gi\|208813183\|ref\|ZP_03254512.1\| protein aegA [Escherichia coli O157:H7 str. EC4045], gi\|208734460\|gb... gi\|208739983, gi... - gi\|208819860\|ref\|ZP_03260180.1\| protein aegA [Escherichia coli O157:H7 str. EC4042], gi\|208739983\|gb... gi\|168773627, gi... - gi\|187770732\|gb\|EDU34576.1\| protein aegA [Escherichia coli O157:H7 str. EC4196], gi\|168773627\|ref\|ZP... gi\|168778426, gi... - gi\|189003194\|gb\|EDU72180.1\| protein aegA [Escherichia coli O157:H7 str. EC4076], gi\|168778426\|ref\|ZP... gi\|189372387, gi... - gi\|189372387\|gb\|EDU90803.1\| protein aegA [Escherichia coli O157:H7 str. EC869], gi\|168787806\|ref\|ZP_... gi\|189378607, gi... - gi\|189378607\|gb\|EDU97023.1\| protein aegA [Escherichia coli O157:H7 str. EC508], gi\|168798831\|ref\|ZP_... gi\|188017016, gi... - gi\|188017016\|gb\|EDU55138.1\| protein aegA [Escherichia coli O157:H7 str. EC4113], gi\|168748482\|ref\|ZP... gi\|189356550, gi... - gi\|189356550\|gb\|EDU74969.1\| protein aegA [Escherichia coli O157:H7 str. EC4401], gi\|168756232\|ref\|ZP... gi\|254593812, gi... - gi\|254794412\|ref\|YP_003079249.1\| fused predicted oxidoreductase: FeS binding subunit, NAD [Escherich... gi\|168761069, gi... - gi\|189368496\|gb\|EDU86912.1\| protein aegA [Escherichia coli O157:H7 str. EC4501], gi\|168761069\|ref\|ZP... gi\|189362302, gi... - gi\|189362302\|gb\|EDU80721.1\| protein aegA [Escherichia coli O157:H7 str. EC4486], gi\|168768552\|ref\|ZP... gi\|15832584, gi\|... - gi\|15832584\|ref\|NP_311357.1\| putative oxidoreductase Fe-S binding subunit [Escherichia coli O157:H7 ...	524.0	[0..1]	[659..1]
gi\|26109243, gi\|... - gi\|26248837\|ref\|NP_754877.1\| putative oxidoreductase Fe-S binding subunit [Escherichia coli CFT073],... gi\|227835854, gi... - gi\|227887504\|ref\|ZP_04005309.1\| Fe-S center and glutamate synthase (GltD) protein [Escherichia coli ...	523.0	[0..1]	[659..1]
gi\|91073373, gi\|... - gi\|91211799\|ref\|YP_541785.1\| putative oxidoreductase Fe-S binding subunit [Escherichia coli UTI89], ... gi\|218559403, gi... - gi\|218559403\|ref\|YP_002392316.1\| putative oxidoreductase Fe-S binding subunit [Escherichia coli S88]... gi\|117624664, gi... - gi\|117624664\|ref\|YP_853577.1\| putative oxidoreductase Fe-S binding subunit [Escherichia coli APEC O1... gi\|237704983, gi... - gi\|237704983\|ref\|ZP_04535464.1\| AegA protein [Escherichia sp. 3_2_53FAA], gi\|226901349\|gb\|EEH87608.1...	522.0	[0..1]	[659..1]
gi\|24113797, gi\|... - gi\|24113797\|ref\|NP_708307.1\| putative oxidoreductase Fe-S binding subunit [Shigella flexneri 2a str.... gi\|30042103, gi\|... - gi\|30063848\|ref\|NP_838019.1\| putative oxidoreductase Fe-S binding subunit [Shigella flexneri 2a str....	522.0	[0..1]	[659..1]

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Predicted Domain #1

Region A:
Residues: [1-178]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRFIMANSQ QCLGCHACEI ACVMAHNDEQ HVLSQHHFHP RITVIKHQQQ RSAVTCHHCE  60
   61 DAPCARSCPN GAISHVDDSI QVNQQKCIGC KSCVVACPFG TMQIVLTPVA AGKVKATAHK 120
  121 CDLCAGRENG PACVENCPAD ALQLVTDVAL SGMAKSRRLR TARQEHQPWH ASTAAQEM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.221849
Match:	1kqfB
Description:	Formate dehydrogenase N, iron-sulfur (beta) subunit; Iron-sulfur subunit of formate dehydrogenase N, transmembrane anchor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	0.660370448422897	bayes_pls_golite062009
catalytic activity	0.488483980994331	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [179-659]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVMSKVEQMQ ATPARGEPDK LAIEARKTGF DEIYLPFRAD QAQREASRCL KCGEHSVCEW  60
   61 TCPLHNHIPQ WIELVKAGNI DAAVELSHQT NTLPEITGRV CPQDRLCEGA CTIRDEHGAV 120
  121 TIGNIERYIS DQALAKGWRP DLSHVTKVDK RVAIIGAGPA GLACADVLTR NGVGVTVYDR 180
  181 HPEIGGLLTF GIPSFKLDKS LLARRREIFS AMGIHFELNC EVGKDVSLDS LLEQYDAVFV 240
  241 GVGTYRSMKA GLPNEDAPGV YDALPFLIAN TKQVMGLEEL PEEPFINTAG LNVVVLGGGD 300
  301 TAMDCVRTAL RHGASNVTCA YRRDEANMPG SKKEVKNARE EGANFEFNVQ PVALELNEQG 360
  361 HVCGIRFLRT RLGEPDAQGR RRPVPVEGSE FVMPADAVIM AFGFNPHGMP WLESHGVTVD 420
  421 KWGRIIADVE SQYRYQTTNP KIFAGGDAVR GADLVVTAMA EGRHAAQGII DWLGVKSVKS 480
  481 H

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	61.09691
Match:	1h7xA
Description:	Dihydropyrimidine dehydrogenase, N-terminal domain; Dihydropyrimidine dehydrogenase, domain 4; Dihydropyrimidine dehydrogenase, domain 3; Dihydropyrimidine dehydrogenase, domain 2; Dihydropyrimidine dehydrogenase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glutamate synthase activity	8.25305391467034	bayes_pls_golite062009
glutamate synthase activity, NADH or NADPH as acceptor	8.23578981764913	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	7.02480361242491	bayes_pls_golite062009
glutamate synthase (NADPH) activity	6.79992270958953	bayes_pls_golite062009
succinate dehydrogenase activity	1.80846474206463	bayes_pls_golite062009
oxidoreductase activity	1.79641444157516	bayes_pls_golite062009
catalytic activity	1.56773888754354	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	0.384435272305167	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: