YRC Public Data Repository - Protein Structure Prediction

Protein:	ACRE_ECOLI
Organism:	Escherichia coli
Length:	385 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACRE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|190905871, gi... - gi\|75237874\|ref\|ZP_00721885.1\| COG0845: Membrane-fusion protein [Escherichia coli F11], gi\|191173821...	299.0	[0..1]	[385..1]
gi\|110345102, gi... - gi\|110643510\|ref\|YP_671240.1\| acriflavine resistance protein E precursor [Escherichia coli 536], gi\|...	298.0	[0..1]	[385..1]
gi\|36787147, gi\|... - gi\|37527711\|ref\|NP_931056.1\| acriflavin resistance protein A precursor [Photorhabdus luminescens sub...	297.0	[0..1]	[384..1]
gi\|112182847, gi... - gi\|148807119\|gb\|ABR13270.1\| AcrA [Enterobacter cloacae], gi\|112182847\|emb\|CAL18625.1\| AcrA protein [...	295.0	[0..1]	[384..1]
gi\|26246476, gi\|... - gi\|26246476\|ref\|NP_752515.1\| acriflavin resistance protein A [Escherichia coli CFT073], gi\|26106874\|... gi\|170519553, gi... - gi\|170681835\|ref\|YP_001742607.1\| acriflavine resistance protein A [Escherichia coli SMS-3-5], gi\|170... gi\|91209536, gi\|... - gi\|91209536\|ref\|YP_539522.1\| acriflavine resistance protein A precursor [Escherichia coli UTI89], gi... gi\|191173671, gi... - gi\|191173671\|ref\|ZP_03035195.1\| acriflavine resistance protein A [Escherichia coli F11], gi\|19090602...	294.0	[0..1]	[384..13]
gi\|78222029, gi\|... - gi\|78222029\|ref\|YP_383776.1\| secretion protein HlyD [Geobacter metallireducens GS-15], gi\|78193284\|g...	294.0	[0..5]	[384..3]
gi\|56384967 - gi\|56384967\|gb\|AAV85949.1\| AcrA [Morganella morganii]	293.0	[0..1]	[384..1]
gi\|194411708, gi... - gi\|75208485\|ref\|ZP_00708807.1\| COG0845: Membrane-fusion protein [Escherichia coli B171], gi\|19443023...	292.0	[0..1]	[385..1]
gi\|15833391, gi\|... - gi\|15833391\|ref\|NP_312164.1\| transmembrane protein affects septum formation and cell membrane permea... gi\|209757490, gi... - pir\|\|E85991 hypothetical protein acrE [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|217327499, gi... - gi\|217327499\|ref\|ZP_03443582.1\| acriflavine resistance protein E [Escherichia coli O157:H7 str. TW14... gi\|209160435, gi... - gi\|209399035\|ref\|YP_002272727.1\| acriflavine resistance protein E [Escherichia coli O157:H7 str. EC4... gi\|15803799, gi\|... - gi\|15803799\|ref\|NP_289833.1\| transmembrane protein affects septum formation and cell membrane permea... gi\|208818713, gi... - gi\|208818713\|ref\|ZP_03259033.1\| acriflavine resistance protein E [Escherichia coli O157:H7 str. EC40... gi\|15833391, gi\|... - gi\|15833391\|ref\|NP_312164.1\| transmembrane protein affects septum formation and cell membrane permea... gi\|208734521, gi... - gi\|208813244\|ref\|ZP_03254573.1\| acriflavine resistance protein E [Escherichia coli O157:H7 str. EC40... gi\|168783834, gi... - gi\|188998868\|gb\|EDU67854.1\| acriflavine resistance protein E [Escherichia coli O157:H7 str. EC4076],... gi\|187767125, gi... - gi\|187767125\|gb\|EDU30969.1\| acriflavine resistance protein E [Escherichia coli O157:H7 str. EC4196],... gi\|189361837, gi... - gi\|189361837\|gb\|EDU80256.1\| acriflavine resistance protein E [Escherichia coli O157:H7 str. EC4486],... gi\|189365194, gi... - gi\|189365194\|gb\|EDU83610.1\| acriflavine resistance protein E [Escherichia coli O157:H7 str. EC4501],... gi\|208729482, gi... - gi\|208809681\|ref\|ZP_03252018.1\| acriflavine resistance protein E [Escherichia coli O157:H7 str. EC42... gi\|195940009 - gi\|195940009\|ref\|ZP_03085391.1\| transmembrane protein affects septum formation and cell membrane per... gi\|189375425, gi... - gi\|189375425\|gb\|EDU93841.1\| acriflavine resistance protein E [Escherichia coli O157:H7 str. EC508], ... gi\|168786158, gi... - gi\|189373891\|gb\|EDU92307.1\| acriflavine resistance protein E [Escherichia coli O157:H7 str. EC869], ... gi\|254594608, gi... - gi\|254795208\|ref\|YP_003080045.1\| cytoplasmic membrane lipoprotein [Escherichia coli O157:H7 str. TW1... gi\|168758495, gi... - gi\|189354669\|gb\|EDU73088.1\| acriflavine resistance protein E [Escherichia coli O157:H7 str. EC4401],... gi\|168752400, gi... - gi\|188013754\|gb\|EDU51876.1\| acriflavine resistance protein E [Escherichia coli O157:H7 str. EC4113],...	292.0	[0..1]	[385..1]
gi\|75176272, gi\|... - gi\|75176272\|ref\|ZP_00696424.1\| COG0845: Membrane-fusion protein [Shigella boydii BS512], gi\|18773011...	292.0	[0..1]	[385..1]

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Predicted Domain #1

Region A:
Residues: [1-385]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKHARFFLL PSFILISAAL IAGCNDKGEE KAHVGEPQVT VHIVKTAPLE VKTELPGRTN  60
   61 AYRIAEVRPQ VSGIVLNRNF TEGSDVQAGQ SLYQIDPATY QANYDSAKGE LAKSEAAAAI 120
  121 AHLTVKRYVP LVGTKYISQQ EYDQAIADAR QADAAVIAAK ATVESARINL AYTKVTAPIS 180
  181 GRIGKSTVTE GALVTNGQTT ELATVQQLDP IYVDVTQSSN DFMRLKQSVE QGNLHKENAT 240
  241 SNVELVMENG QTYPLKGTLQ FSDVTVDEST GSITLRAVFP NPQHTLLPGM FVRARIDEGV 300
  301 QPDAILIPQQ GVSRTPRGDA TVLIVNDKSQ VEARPVVASQ AIGDKWLISE GLKSGDQVIV 360
  361 SGLQKARPGE QVKATTDTPA DTASK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.522879
Match:	1t5eA
Description:	The structure of MexA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
drug transmembrane transporter activity	6.72943251269963	bayes_pls_golite062009
	6.35210689530056	bayes_pls_golite062009
	6.27508108329198	bayes_pls_golite062009
transporter activity	4.64829294279324	bayes_pls_golite062009
transmembrane transporter activity	3.3430410220484	bayes_pls_golite062009
protein transporter activity	2.78337364594901	bayes_pls_golite062009
substrate-specific transporter activity	2.32388774487807	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.892013812755237	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.729251657794536	bayes_pls_golite062009
ion transmembrane transporter activity	0.696350598512404	bayes_pls_golite062009
cation transmembrane transporter activity	0.560994844134224	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: