YRC Public Data Repository - Protein Structure Prediction

Protein:	ACRD_ECOLI
Organism:	Escherichia coli
Length:	1037 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACRD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|75229208, gi\|... - gi\|75229208\|ref\|ZP_00715776.1\| COG0841: Cation/multidrug efflux pump [Escherichia coli B7A], gi\|1911... gi\|209919942, gi... - gi\|209919942\|ref\|YP_002294026.1\| aminoglycoside/multidrug efflux system [Escherichia coli SE11], gi\|...	894.0	[0..1]	[1037..1]
gi\|157080537, gi... - gi\|75187214\|ref\|ZP_00700481.1\| COG0841: Cation/multidrug efflux pump [Escherichia coli E24377A], gi\|...	893.0	[0..1]	[1037..1]
gi\|26109245, gi\|... - gi\|26248839\|ref\|NP_754879.1\| aminoglycoside/multidrug efflux system [Escherichia coli CFT073], gi\|26...	893.0	[0..1]	[1037..1]
gi\|191172943, gi... - gi\|75240119\|ref\|ZP_00724078.1\| COG0841: Cation/multidrug efflux pump [Escherichia coli F11], gi\|1911...	892.0	[0..1]	[1037..1]
gi\|218559405, gi... - gi\|218559405\|ref\|YP_002392318.1\| aminoglycoside/multidrug efflux system [Escherichia coli S88], gi\|2... gi\|91211801, gi\|... - gi\|91211801\|ref\|YP_541787.1\| aminoglycoside/multidrug efflux system [Escherichia coli UTI89], gi\|910... gi\|218696096, gi... - gi\|218696096\|ref\|YP_002403763.1\| aminoglycoside/multidrug efflux system [Escherichia coli 55989], gi... gi\|226901351, gi... - gi\|237704985\|ref\|ZP_04535466.1\| aminoglycoside/multidrug efflux system [Escherichia sp. 3_2_53FAA], ... gi\|218361761, gi... - gi\|218554993\|ref\|YP_002387906.1\| aminoglycoside/multidrug efflux system [Escherichia coli IAI1], gi\|... gi\|218700926, gi... - gi\|218700926\|ref\|YP_002408555.1\| aminoglycoside/multidrug efflux system [Escherichia coli IAI39], gi... gi\|192927659, gi... - gi\|75257273\|ref\|ZP_00728797.1\| COG0841: Cation/multidrug efflux pump [Escherichia coli E22], gi\|1930... gi\|115513790, gi... - gi\|117624666\|ref\|YP_853579.1\| aminoglycoside/multidrug efflux system [Escherichia coli APEC O1], gi\|...	892.0	[0..1]	[1037..1]
gi\|192958289, gi... - gi\|75237787\|ref\|ZP_00721803.1\| COG0841: Cation/multidrug efflux pump [Escherichia coli E110019], gi\|...	892.0	[0..1]	[1037..1]
gi\|24113798, gi\|... - gi\|24113798\|ref\|NP_708308.1\| aminoglycoside/multidrug efflux system [Shigella flexneri 2a str. 301],... gi\|30042104, gi\|... - gi\|30063849\|ref\|NP_838020.1\| aminoglycoside/multidrug efflux system [Shigella flexneri 2a str. 2457T...	892.0	[0..1]	[1037..1]
gi\|953226 - gi\|953226\|gb\|AAA74741.1\| 1037 amino acids, 113 kDa protein	891.0	[0..1]	[1037..1]
gi\|110344234, gi... - gi\|110642642\|ref\|YP_670372.1\| aminoglycoside/multidrug efflux system [Escherichia coli 536], gi\|1103...	891.0	[0..1]	[1037..1]
gi\|74312995, gi\|... - gi\|74312995\|ref\|YP_311414.1\| aminoglycoside/multidrug efflux system [Shigella sonnei Ss046], gi\|7385...	891.0	[0..1]	[1037..1]

Back

Predicted Domain #1

Region A:
Residues: [1-1037]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANFFIDRPI FAWVLAILLC LTGTLAIFSL PVEQYPDLAP PNVRVTANYP GASAQTLENT  60
   61 VTQVIEQNMT GLDNLMYMSS QSSGTGQASV TLSFKAGTDP DEAVQQVQNQ LQSAMRKLPQ 120
  121 AVQNQGVTVR KTGDTNILTI AFVSTDGSMD KQDIADYVAS NIQDPLSRVN GVGDIDAYGS 180
  181 QYSMRIWLDP AKLNSFQMTA KDVTDAIESQ NAQIAVGQLG GTPSVDKQAL NATINAQSLL 240
  241 QTPEQFRDIT LRVNQDGSEV RLGDVATVEM GAEKYDYLSR FNGKPASGLG VKLASGANEM 300
  301 ATAELVLNRL DELAQYFPHG LEYKVAYETT SFVKASIEDV VKTLLEAIAL VFLVMYLFLQ 360
  361 NFRATLIPTI AVPVVLMGTF SVLYAFGYSV NTLTMFAMVL AIGLLVDDAI VVVENVERIM 420
  421 SEEGLTPREA TRKSMGQIQG ALVGIAMVLS AVFVPMAFFG GTTGAIYRQF SITIVAAMVL 480
  481 SVLVAMILTP ALCATLLKPL KKGEHHGQKG FFAWFNQMFN RNAERYEKGV AKILHRSLRW 540
  541 IVIYVLLLGG MVFLFLRLPT SFLPLEDRGM FTTSVQLPSG STQQQTLKVV EQIEKYYFTH 600
  601 EKDNIMSVFA TVGSGPGGNG QNVARMFIRL KDWSERDSKT GTSFAIIERA TKAFNQIKEA 660
  661 RVIASSPPAI SGLGSSAGFD MELQDHAGAG HDALMAARNQ LLALAAENPE LTRVRHNGLD 720
  721 DSPQLQIDID QRKAQALGVA IDDINDTLQT AWGSSYVNDF MDRGRVKKVY VQAAAPYRML 780
  781 PDDINLWYVR NKDGGMVPFS AFATSRWETG SPRLERYNGY SAVEIVGEAA PGVSTGTAMD 840
  841 IMESLVKQLP NGFGLEWTAM SYQERLSGAQ APALYAISLL VVFLCLAALY ESWSVPFSVM 900
  901 LVVPLGVIGA LLATWMRGLE NDVYFQVGLL TVIGLSAKNA ILIVEFANEM NQKGHDLFEA 960
  961 TLHACRQRLR PILMTSLAFI FGVLPMATST GAGSGGQHAV GTGVMGGMIS ATILAIYFVP1020
 1021 LFFVLVRRRF PLKPRPE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1oy6A
Description:	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
	5.76635084475529	bayes_pls_golite062009
drug transmembrane transporter activity	5.26216058720248	bayes_pls_golite062009
	4.79371622943198	bayes_pls_golite062009
transporter activity	1.3820077421337	bayes_pls_golite062009
transmembrane transporter activity	1.24821957412828	bayes_pls_golite062009
substrate-specific transporter activity	0.12397386858091	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: