YRC Public Data Repository - Protein Structure Prediction

Protein:	ACRA_ECOLI
Organism:	Escherichia coli
Length:	397 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACRA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|26246476, gi\|... - gi\|26246476\|ref\|NP_752515.1\| acriflavin resistance protein A [Escherichia coli CFT073], gi\|26106874\|... gi\|170519553, gi... - gi\|170681835\|ref\|YP_001742607.1\| acriflavine resistance protein A [Escherichia coli SMS-3-5], gi\|170... gi\|91209536, gi\|... - gi\|91209536\|ref\|YP_539522.1\| acriflavine resistance protein A precursor [Escherichia coli UTI89], gi... gi\|191173671, gi... - gi\|191173671\|ref\|ZP_03035195.1\| acriflavine resistance protein A [Escherichia coli F11], gi\|19090602...	315.0	[0..1]	[397..13]
gi\|112182847, gi... - gi\|148807119\|gb\|ABR13270.1\| AcrA [Enterobacter cloacae], gi\|112182847\|emb\|CAL18625.1\| AcrA protein [...	313.0	[0..1]	[397..1]
gi\|110804490, gi... - gi\|110804490\|ref\|YP_688010.1\| acriflavin resistance protein A [Shigella flexneri 5 str. 8401], gi\|11...	312.0	[0..1]	[397..13]
gi\|117622721, gi... - gi\|117622721\|ref\|YP_851634.1\| acriflavine resistance protein A precursor [Escherichia coli APEC O1],... gi\|222355825 - gi\|222355825\|gb\|ACM48570.1\| acriflavine resistance protein A [Escherichia coli] gi\|218698625, gi... - gi\|218698625\|ref\|YP_002406254.1\| multidrug efflux system [Escherichia coli IAI39], gi\|218368611\|emb\|... gi\|237707541, gi... - gi\|237707541\|ref\|ZP_04538022.1\| acriflavine resistance protein A [Escherichia sp. 3_2_53FAA], gi\|226... gi\|75238215 - gi\|75238215\|ref\|ZP_00722216.1\| COG0845: Membrane-fusion protein [Escherichia coli F11] gi\|218703746, gi... - gi\|218703746\|ref\|YP_002411265.1\| multidrug efflux system [Escherichia coli UMN026], gi\|218430843\|emb... gi\|227884525, gi... - gi\|227884525\|ref\|ZP_04002330.1\| acridine efflux pump [Escherichia coli 83972], gi\|227838611\|gb\|EEJ49... gi\|215263615, gi... - gi\|215485543\|ref\|YP_002327974.1\| multidrug efflux system [Escherichia coli O127:H6 str. E2348/69], g... gi\|218557373, gi... - gi\|218557373\|ref\|YP_002390286.1\| multidrug efflux system [Escherichia coli S88], gi\|218364142\|emb\|CA...	312.0	[0..1]	[397..1]
gi\|82775806, gi\|... - gi\|82775806\|ref\|YP_402153.1\| acridine efflux pump [Shigella dysenteriae Sd197], gi\|81239954\|gb\|ABB60...	311.0	[0..1]	[397..1]
gi\|75177593 - gi\|75177593\|ref\|ZP_00697674.1\| COG0845: Membrane-fusion protein [Shigella boydii BS512]	311.0	[0..1]	[397..1]
gi\|73854519, gi\|... - gi\|74311042\|ref\|YP_309461.1\| acridine efflux pump [Shigella sonnei Ss046], gi\|73854519\|gb\|AAZ87226.1...	311.0	[0..1]	[397..1]
gi\|81244367, gi\|... - gi\|82542956\|ref\|YP_406903.1\| acridine efflux pump [Shigella boydii Sb227], gi\|81244367\|gb\|ABB65075.1...	311.0	[0..1]	[397..1]
gi\|30040207, gi\|... - gi\|30061963\|ref\|NP_836134.1\| acriflavin resistance protein AcrA precursor [Shigella flexneri 2a str.... gi\|56479668, gi\|... - gi\|56479668\|ref\|NP_706356.2\| acriflavin resistance protein AcrA precursor [Shigella flexneri 2a str....	309.0	[0..1]	[397..1]
gi\|36787147, gi\|... - gi\|37527711\|ref\|NP_931056.1\| acriflavin resistance protein A precursor [Photorhabdus luminescens sub...	308.0	[0..1]	[395..1]

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Predicted Domain #1

Region A:
Residues: [1-303]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKNRGFTPL AVVLMLSGSL ALTGCDDKQA QQGGQQMPAV GVVTVKTEPL QITTELPGRT  60
   61 SAYRIAEVRP QVSGIILKRN FKEGSDIEAG VSLYQIDPAT YQATYDSAKG DLAKAQAAAN 120
  121 IAQLTVNRYQ KLLGTQYISK QEYDQALADA QQANAAVTAA KAAVETARIN LAYTKVTSPI 180
  181 SGRIGKSNVT EGALVQNGQA TALATVQQLD PIYVDVTQSS NDFLRLKQEL ANGTLKQENG 240
  241 KAKVSLITSD GIKFPQDGTL EFSDVTVDQT TGSITLRAIF PNPDHTLLPG MFVRARLEEG 300
  301 LNP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.0
Match:	2f1mA
Description:	No description for 2f1mA was found.

Predicted Domain #2

Region A:
Residues: [304-397]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAILVPQQGV TRTPRGDATV LVVGADDKVE TRPIVASQAI GDKWLVTEGL KAGDRVVISG  60
   61 LQKVRPGVQV KAQEVTADNN QQAASGAQPE QSKS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.79
Match:	1vf7A
Description:	Crystal structure of the membrane fusion protein, MexA of the multidrug transporter
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
drug transmembrane transporter activity	2.50835594243865	bayes_pls_golite062009
	2.3735050675934	bayes_pls_golite062009
	2.14104517121	bayes_pls_golite062009
transporter activity	1.61298431156112	bayes_pls_golite062009
transmembrane transporter activity	0.376968105599516	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: