YRC Public Data Repository - Protein Structure Prediction

Protein:	ACON2_ECOLI, ACO...
Organism:	Escherichia coli
Length:	865 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACON2_ECOLI, ACO....

Description	E-value	Query Range	Subject Range
gi\|25517479 - pir\|\|AI0414 aconitate hydratase (EC 4.2.1.3) [imported] - Yersinia pestis (strain CO92) gi\|45440130, gi\|... - gi\|45440130\|ref\|NP_991669.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [Yers... gi\|21957496, gi\|... - gi\|22124684\|ref\|NP_668107.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [Yers... gi\|153997542, gi... - gi\|153997542\|ref\|ZP_02022642.1\| aconitate hydratase 2 [Yersinia pestis CA88-4125], gi\|149289179\|gb\|E... gi\|15981342, gi\|... - gi\|218930432\|ref\|YP_002348307.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [... gi\|77634820, gi\|... - gi\|77634820\|ref\|ZP_00796913.1\| COG1049: Aconitase B [Yersinia pestis Angola], gi\|162421710\|ref\|YP_00... gi\|165991075, gi... - gi\|166010168\|ref\|ZP_02231066.1\| aconitate hydratase 2 [Yersinia pestis biovar Antiqua str. E1979001]... gi\|51595066, gi\|... - gi\|51595066\|ref\|YP_069257.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [Yers... gi\|153950127, gi... - gi\|77631694\|ref\|ZP_00794280.1\| COG1049: Aconitase B [Yersinia pseudotuberculosis IP 31758], gi\|15395... gi\|165922367, gi... - gi\|165925755\|ref\|ZP_02221587.1\| aconitate hydratase 2 [Yersinia pestis biovar Orientalis str. F19910... Q66EH7\|Q66EH7_YERPS - Aconitate hydratase 2 - Yersinia pseudotuberculosis gi\|229695422, gi... - gi\|229839056\|ref\|ZP_04459215.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [Y... gi\|229896535, gi... - gi\|229896535\|ref\|ZP_04511703.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [Y... gi\|229687112, gi... - gi\|229899620\|ref\|ZP_04514761.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [Y... gi\|167399671, gi... - gi\|167399671\|ref\|ZP_02305195.1\| aconitate hydratase 2 [Yersinia pestis biovar Antiqua str. UG05-0454... gi\|166214101, gi... - gi\|166214101\|ref\|ZP_02240136.1\| aconitate hydratase 2 [Yersinia pestis biovar Antiqua str. B42003004... gi\|167057706, gi... - gi\|167423536\|ref\|ZP_02315289.1\| aconitate hydratase 2 [Yersinia pestis biovar Mediaevalis str. K1973... gi\|167420702, gi... - gi\|167420702\|ref\|ZP_02312455.1\| aconitate hydratase 2 [Yersinia pestis biovar Orientalis str. MG05-1... gi\|89104443, gi\|... - gi\|89104443\|ref\|ZP_01176986.1\| COG1049: Aconitase B [Yersinia pestis biovar Orientalis str. IP275], ... gi\|170025702, gi... - gi\|170025702\|ref\|YP_001722207.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [... gi\|108808908, gi... - gi\|108808908\|ref\|YP_652824.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [Yer... gi\|167470689 - gi\|167470689\|ref\|ZP_02335393.1\| aconitate hydratase 2 [Yersinia pestis FV-1] gi\|229901044, gi... - gi\|229901044\|ref\|ZP_04516167.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [Y... gi\|186894075, gi... - gi\|186894075\|ref\|YP_001871187.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [...	1246.0	[0..1]	[865..1]
gi\|77976069, gi\|... - gi\|77976069\|ref\|ZP_00831602.1\| COG1049: Aconitase B [Yersinia frederiksenii ATCC 33641], gi\|23878675...	1244.0	[0..1]	[865..1]
gi\|75258889 - gi\|75258889\|ref\|ZP_00730279.1\| COG1049: Aconitase B [Escherichia coli E22]	1243.0	[0..1]	[865..1]
gi\|28807493, gi\|... - gi\|28899269\|ref\|NP_798874.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [Vibr... gi\|28807493 - gi\|28807493\|dbj\|BAC60758.1\| aconitate hydratase 2 [Vibrio parahaemolyticus RIMD 2210633]	1240.0	[0..1]	[863..1]
gi\|77977272 - gi\|77977272\|ref\|ZP_00832725.1\| COG1049: Aconitase B [Yersinia intermedia ATCC 29909]	1239.0	[0..1]	[865..14]
gi\|238797677, gi... - gi\|77962127\|ref\|ZP_00825952.1\| COG1049: Aconitase B [Yersinia mollaretii ATCC 43969], gi\|238797677\|r...	1237.0	[0..1]	[865..1]
gi\|91187549, gi\|... - gi\|91228900\|ref\|ZP_01262801.1\| aconitate hydratase [Vibrio alginolyticus 12G01], gi\|91187549\|gb\|EAS7...	1235.0	[0..1]	[863..1]
gi\|238785078, gi... - gi\|77957554\|ref\|ZP_00821607.1\| COG1049: Aconitase B [Yersinia bercovieri ATCC 43970], gi\|238785078\|r...	1233.0	[0..1]	[865..1]
gi\|227080785, gi... - gi\|227080785\|ref\|YP_002809336.1\| aconitate hydratase 2 [Vibrio cholerae M66-2], gi\|227008673\|gb\|ACP0... gi\|229505772, gi... - gi\|229505772\|ref\|ZP_04395282.1\| aconitate hydratase 2 [Vibrio cholerae BX 330286], gi\|229357995\|gb\|E... gi\|254846541, gi... - gi\|75828888\|ref\|ZP_00758219.1\| COG1049: Aconitase B [Vibrio cholerae MO10], gi\|254850836\|ref\|ZP_0524... gi\|229512867, gi... - gi\|229512867\|ref\|ZP_04402334.1\| aconitate hydratase 2 [Vibrio cholerae TMA 21], gi\|229350116\|gb\|EEO1... gi\|227116979, gi... - gi\|75825968\|ref\|ZP_00755403.1\| COG1049: Aconitase B [Vibrio cholerae O395], gi\|227116979\|ref\|YP_0028... gi\|229519596, gi... - gi\|229519596\|ref\|ZP_04409039.1\| aconitate hydratase 2 [Vibrio cholerae RC9], gi\|229344285\|gb\|EEO0926... gi\|9655036, gi\|1... - gi\|9655036\|gb\|AAF93771.1\| aconitate hydratase 2 [Vibrio cholerae O1 biovar El Tor str. N16961], gi\|1... gi\|75822539, gi\|... - gi\|75822539\|ref\|ZP_00752146.1\| COG1049: Aconitase B [Vibrio cholerae RC385], gi\|254224245\|ref\|ZP_049... gi\|229520894, gi... - gi\|229520894\|ref\|ZP_04410316.1\| aconitate hydratase 2 [Vibrio cholerae TM 11079-80], gi\|229342127\|gb... gi\|11354383 - pir\|\|C82303 aconitate hydratase 2 VC0604 [imported] - Vibrio cholerae (strain N16961 serogroup O1) gi\|229338839, gi... - gi\|229525258\|ref\|ZP_04414663.1\| aconitate hydratase 2 [Vibrio cholerae bv. albensis VL426], gi\|22933... gi\|229371538, gi... - gi\|229608883\|ref\|YP_002879531.1\| 2-methylisocitrate dehydratase [Vibrio cholerae MJ-1236], gi\|229371... gi\|254291258, gi... - gi\|254291258\|ref\|ZP_04962053.1\| aconitate hydratase 2 [Vibrio cholerae AM-19226], gi\|197751397\|ref\|Y... gi\|148875390, gi... - gi\|153829132\|ref\|ZP_01981799.1\| aconitate hydratase 2 [Vibrio cholerae 623-39], gi\|148875390\|gb\|EDL7... gi\|149740635, gi... - gi\|153825698\|ref\|ZP_01978365.1\| aconitate hydratase 2 [Vibrio cholerae MZO-2], gi\|149740635\|gb\|EDM54... gi\|125620608, gi... - gi\|254226857\|ref\|ZP_04920427.1\| aconitate hydratase 2 [Vibrio cholerae V51], gi\|225354468\|ref\|YP_002... gi\|121591125, gi... - gi\|121591125\|ref\|ZP_01678433.1\| aconitate hydratase 2 [Vibrio cholerae 2740-80], gi\|121547021\|gb\|EAX... gi\|124121162, gi... - gi\|153803304\|ref\|ZP_01957890.1\| aconitate hydratase 2 [Vibrio cholerae MZO-3], gi\|124121162\|gb\|EAY39... gi\|153819855, gi... - gi\|153819855\|ref\|ZP_01972522.1\| aconitate hydratase 2 [Vibrio cholerae NCTC 8457], gi\|126509601\|gb\|E... gi\|229509194, gi... - gi\|229509194\|ref\|ZP_04398679.1\| aconitate hydratase 2 [Vibrio cholerae B33], gi\|229353766\|gb\|EEO1870...	1226.0	[0..1]	[863..1]
gi\|190905486, gi... - gi\|191174253\|ref\|ZP_03035763.1\| aconitate hydratase 2 [Escherichia coli F11], gi\|190905486\|gb\|EDV651... gi\|237704274, gi... - gi\|237704274\|ref\|ZP_04534755.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [E... gi\|117622405, gi... - gi\|117622405\|ref\|YP_851318.1\| bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [Esc... gi\|91209186, gi\|... - gi\|91209186\|ref\|YP_539172.1\| aconitate hydratase 2 [Escherichia coli UTI89], gi\|91070760\|gb\|ABE05641... gi\|26246058, gi\|... - gi\|26246058\|ref\|NP_752097.1\| aconitate hydratase [Escherichia coli CFT073], gi\|26106455\|gb\|AAN78641....	1226.0	[0..1]	[865..52]

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Predicted Domain #1

Region A:
Residues: [1-865]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEEYRKHVA ERAAEGIAPK PLDANQMAAL VELLKNPPAG EEEFLLDLLT NRVPPGVDEA  60
   61 AYVKAGFLAA IAKGEAKSPL LTPEKAIELL GTMQGGYNIH PLIDALDDAK LAPIAAKALS 120
  121 HTLLMFDNFY DVEEKAKAGN EYAKQVMQSW ADAEWFLNRP ALAEKLTVTV FKVTGETNTD 180
  181 DLSPAPDAWS RPDIPLHALA MLKNAREGIE PDQPGVVGPI KQIEALQQKG FPLAYVGDVV 240
  241 GTGSSRKSAT NSVLWFMGDD IPHVPNKRGG GLCLGGKIAP IFFNTMEDAG ALPIEVDVSN 300
  301 LNMGDVIDVY PYKGEVRNHE TGELLATFEL KTDVLIDEVR AGGRIPLIIG RGLTTKAREA 360
  361 LGLPHSDVFR QAKDVAESDR GFSLAQKMVG RACGVKGIRP GAYCEPKMTS VGSQDTTGPM 420
  421 TRDELKDLAC LGFSADLVMQ SFCHTAAYPK PVDVNTHHTL PDFIMNRGGV SLRPGDGVIH 480
  481 SWLNRMLLPD TVGTGGDSHT RFPIGISFPA GSGLVAFAAA TGVMPLDMPE SVLVRFKGKM 540
  541 QPGITLRDLV HAIPLYAIKQ GLLTVEKKGK KNIFSGRILE IEGLPDLKVE QAFELTDASA 600
  601 ERSAAGCTIK LNKEPIIEYL NSNIVLLKWM IAEGYGDRRT LERRIQGMEK WLANPELLEA 660
  661 DADAEYAAVI DIDLADIKEP ILCAPNDPDD ARPLSAVQGE KIDEVFIGSC MTNIGHFRAA 720
  721 GKLLDAHKGQ LPTRLWVAPP TRMDAAQLTE EGYYSVFGKS GARIEIPGCS LCMGNQARVA 780
  781 DGATVVSTST RNFPNRLGTG ANVFLASAEL AAVAALIGKL PTPEEYQTYV AQVDKTAVDT 840
  841 YRYLNFNQLS QYTEKADGVI FQTAV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1l5jA
Description:	Aconitase B, N-terminal domain; Aconitase B, second N-terminal domain; Aconitase B, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-isopropylmalate dehydratase activity	11.6597692115322	bayes_pls_golite062009
aconitate hydratase activity	4.71920913892019	bayes_pls_golite062009
structural constituent of ribosome	2.93956285477489	bayes_pls_golite062009
catalytic activity	2.4040324437254	bayes_pls_golite062009
2-methylisocitrate dehydratase activity	2.10696868158801	bayes_pls_golite062009
carbon-oxygen lyase activity	2.08349115784849	bayes_pls_golite062009
hydro-lyase activity	2.04845291489052	bayes_pls_golite062009
lyase activity	2.0080619912194	bayes_pls_golite062009
nucleic acid binding	1.38665120581594	bayes_pls_golite062009
binding	1.03925793375799	bayes_pls_golite062009
structural molecule activity	0.870913754566634	bayes_pls_golite062009
DNA binding	0.682819555450327	bayes_pls_golite062009
mRNA binding	0.52321922280827	bayes_pls_golite062009
RNA binding	0.41480744631042	bayes_pls_golite062009
protein binding	0.232638130896339	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: