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View Structure Prediction Details

Protein: CE36601
Organism: Caenorhabditis elegans
Length: 532 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE36601.

Description E-value Query
Range
Subject
Range
gi|30584247, gi|... - gi|60653005|gb|AAX29197.1| general transcription factor IIH polypeptide 1 62kDa [synthetic construct...
566.0 [0..2] [531..3]

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Predicted Domain #1
Region A:
Residues: [1-121]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDESEALLR VDHVKYRKAG DGKSPIGRLA LFTDFIEWRD NASPEVFTCK FIRINGQRVS  60
   61 PPHKSKVQLQ LILKNEDQAT FVFLNPSASK EDLVKERDAV KEALQSALVK HRHRVNELAK 120
  121 S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.69897
Match: 1pfjA
Description: Solution structure of the N-terminal PH/PTB domain of the TFIIH P62 subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 6.19860786133833 bayes_pls_golite062009
binding 3.29080729281876 bayes_pls_golite062009
protein binding 3.17213698546013 bayes_pls_golite062009
transcription regulator activity 2.10584700564436 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.05456820914801 bayes_pls_golite062009
nucleic acid binding 1.85794418941003 bayes_pls_golite062009
DNA binding 1.77960272183811 bayes_pls_golite062009
transcription elongation regulator activity 1.38051627844132 bayes_pls_golite062009
enzyme binding 0.977337620102034 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.704949129344961 bayes_pls_golite062009
protein kinase activity 0.565124275151513 bayes_pls_golite062009
structure-specific DNA binding 0.361321073558889 bayes_pls_golite062009
hydrolase activity 0.354215977182915 bayes_pls_golite062009
cytoskeletal protein binding 0.268141992393579 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.242734483980252 bayes_pls_golite062009
protein domain specific binding 0.236765394237244 bayes_pls_golite062009
kinase activity 0.206532566781865 bayes_pls_golite062009
kinase binding 0.144753921529348 bayes_pls_golite062009
protein serine/threonine kinase activity 0.0735802149531289 bayes_pls_golite062009
actin binding 0.0485598963526399 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [122-171]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VESQSKQVEL QAKQKILQED RNLEKLYQNL VATKLITPDD FWSDYYQKEG 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.08
Match: 2diiA
Description: No description for 2diiA was found.

Predicted Domain #3
Region A:
Residues: [172-302]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSEDKIGING AFLANIVQQE GTNGVRLNLN PEIIQAIYST YPAVQKKNLE LVPHEMSEEN  60
   61 FWKKFFQSHY FHREREVLPN PKDPFAECVR DDEEEMTKMT AEKIQRKRFD LEHIDDNGLR 120
  121 DFIHKSESQQ K

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 17.39794
Match: PF03909.8
Description: No description for PF03909.8 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.340 0.922 regulation of cyclin-dependent protein kinase activity a.74.1 Cyclin-like

Predicted Domain #4
Region A:
Residues: [303-443]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAKTTLIKRC NYLSEKILAT SWRSGEAAPT TSAAANQKKG FGVLDRLVAE TETRLESEDL  60
   61 ATKEAEDEVQ IVRISSSAKA SQAKYSKPDM TRYKALVTDY FQNSSVEDIL HRNEMLLDQQ 120
  121 EMETWEMEEA METDNNEVPP P

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [444-532]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENWCQSAGDL AKVRDVHSAV REICRQFWKS FPPIDKASEE KLNRMAGTLS KYRDDIRNSD  60
   61 ISKENLTHCI QMIDLAVDKF EAYEMKKMK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle