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View Structure Prediction Details

Protein: dab-1
Organism: Caenorhabditis elegans
Length: 474 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dab-1.

Description E-value Query
Range
Subject
Range
dab-1 - disabled-like protein status:Confirmed UniProt:Q8I4H0 protein_id:CAB54270.3
277.0 [0..9] [474..25]

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Predicted Domain #1
Region A:
Residues: [1-178]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKTQLGRSF SKSFKQKKAR ASNASSDPFR FQNNGISYKG KLIGEQDVDK ARGDAMCAEA  60
   61 MRTAKSIIKA AGAHKTRITL QINIDGIKVL DEKSGAVLHN FPVSRISFIA RDSSDARAFG 120
  121 LVYGEPGGKY KFYGIKTAQA ADQAVLAIRD MFQVVFEMKK KQIEQVKQQQ IQDGGAEI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.0
Match: 1oqnA
Description: Crystal structure of the phosphotyrosine binding domain (PTB) of mouse Disabled 1 (Dab1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.75270183218429 bayes_pls_golite062009
protein binding 1.30337811957526 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [179-393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSKKEGGVAV ADLLDLESEL QQIERGVQQL STVPTNCDAF GASPFGDPFV DSFNSTATSN  60
   61 GTANMSGTQV PFGGLQLPQV QQMQMPMVQI PQQSHQNWPT SGAGSFDAWG QQQQQQQMHH 120
  121 AHSTPAFGTN GFSDTNPFAS AFNTQARPPP LPTVAPTQYR DPFSVHSSAI PNSNIDWTGT 180
  181 GTTKENMAPS TNIQQQQSSL HHASTFANFG DNKAE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [394-474]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TWSEKKVTSL EEAFTKLVDM DALVGGQGIK ETKKNPFEHI LNPPKASLNS MSTTCSAAQM  60
   61 AATQQHTTSS HADPFGDDFF R

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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