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View Structure Prediction Details

Protein: pab-1
Organism: Caenorhabditis elegans
Length: 586 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pab-1.

Description E-value Query
Range
Subject
Range
gi|76689281 - gi|76689281|ref|XP_881384.1| PREDICTED: similar to Polyadenylate-binding protein 4 (Poly(A)-binding ...
428.0 [0..1] [586..72]

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Predicted Domain #1
Region A:
Residues: [1-245]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEMNVAAPAA AVAGAAAPQP GQNQTGSSYT MASLYVGDLH PDVNESILFE KFSAAGPVLS  60
   61 IRVCRDNATR LSLGYAYVNF QQPADAERAM DTMNFEALHG KPMRIMWSQR DPAMRRSGAG 120
  121 NIFIKNLDKV FVGKFQPRAQ RNRELGETAK QFTNVYVKNF GDHYNKETLE KLFAKFGNIT 180
  181 SCEVMTVEGK SKGFGFVAFA NPEEAETAVQ ALHDSTIEGT DLKLHVCRAQ KKSERHAELK 240
  241 KKHEQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.0
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.60920363363072 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
poly-pyrimidine tract binding 1.36691748240059 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [246-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKAERMQKYQ GVNLYVKNLD ETVDDDGLKK QFESYGNITS AKVMTDENGR SKGFGFVCFE  60
   61 KPEEATSAVT EMNSKMVCSK PLYVAIAQRK EDRRAQLASQ YMQRL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.42
Match: 2f3jA
Description: No description for 2f3jA was found.

Predicted Domain #3
Region A:
Residues: [351-447]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASMRMHGNVP GAAMYNPTQP GPGYYVANPM QQQRNFAGGQ QMVRPGGRWG MQNQYPVQNQ  60
   61 YMMAQGPGVY QNRMGRPQNQ QGGPRGPPQQ YNQVAQG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [448-586]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVRMQGPPRT QNPGVQQQNV PRPPQQQQQQ RPAPTGPKAP PQPYQAYQQR PQGIVIGGQE  60
   61 PLTSAMLAAA APQEQKQLLG ERIYALIEKL YPGHKDAGKI TGMMLEIDNS ELIMMLQDSE 120
  121 LFRSKVDEAA SVLVSAQKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.0
Match: 1g9lA
Description: poly(A) binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.11788426448287 bayes_pls_golite062009
mRNA binding 4.06818972936809 bayes_pls_golite062009
nucleic acid binding 3.78909647605682 bayes_pls_golite062009
eukaryotic initiation factor 4G binding 3.4111148675327 bayes_pls_golite062009
single-stranded RNA binding 3.03728178586535 bayes_pls_golite062009
binding 2.76167454154417 bayes_pls_golite062009
poly(A) RNA binding 2.66269581586161 bayes_pls_golite062009
poly-purine tract binding 2.20136693536924 bayes_pls_golite062009
protein binding 0.856075580719879 bayes_pls_golite062009
catalytic activity 0.287695754348243 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle