YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: nhr-25
Organism: Caenorhabditis elegans
Length: 492 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-25.

Description E-value Query
Range
Subject
Range
gi|68396885 - gi|68396885|ref|XP_683221.1| PREDICTED: similar to retinoid X receptor-alpha [Danio rerio]
275.0 [0..45] [465..110]

Back

Predicted Domain #1
Region A:
Residues: [1-135]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGMKMEAVRA DRMRGGRNKF GSFYKKDRAH RMQRNAMRVS TVQVPAVLGA QSQAQTFYQP  60
   61 PEHQVSSSTT DQNNQINYFD QTKIKTEYIK TEYDAHLQSP TLSSSTNQQL SVSDFIMRPG 120
  121 YLVDPQDSLA VLLGS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [136-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TIDDPLLRHT FPAAYQLNEV KQEPFDYSEQ FIHHSLHDYP TYTSNTTNYA TMMPMTTVSS  60
   61 TQSLVTSTSS TTTGRMTEAS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 1ynwB
Description: Crystal Structure of Vitmain D Receptor and 9-cis Retinoic Acid Receptor DNA-Binding Domains Bound to a DR3 Response Element
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [216-492]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STSPILPLCP APTEKTVDHF YNSSIAEMCK TLPDDAQIAR IFTSVKGTSK PEKHAFSIQV  60
   61 AEENLKDIVI WAKNDQLFSK LSLDDQMILL QTSWTTVHIV DITNAMVHGN LLSQYKMSNG 120
  121 DEVPVGLVAL LGNQTFVSSW NDVVIRLRNM GFTNFDYCAF RFLALFDQSM DSFPAVSTAR 180
  181 SRVLQSWREV RCTTAFLEIF EQIRRLAYDS LRYLWNLHSN CPTNWEQFFP EASLVLEMIR 240
  241 TTVNRSASSS VTAITQVPAI QLPTPQATYT AVPYMAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.09691
Match: 1lbdA
Description: LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.31508164334985 bayes_pls_golite062009
transcription regulator activity 2.02157665604796 bayes_pls_golite062009
DNA binding 1.47175550190876 bayes_pls_golite062009
signal transducer activity 1.430912689846 bayes_pls_golite062009
molecular transducer activity 1.430912689846 bayes_pls_golite062009
protein binding 1.34648900580465 bayes_pls_golite062009
nucleic acid binding 1.29377568150934 bayes_pls_golite062009
receptor activity 1.17902442273252 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.16718542519809 bayes_pls_golite062009
transcription activator activity 0.96843436755116 bayes_pls_golite062009
transcription factor activity 0.92060883178562 bayes_pls_golite062009
sequence-specific DNA binding 0.67007540744134 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle