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View Structure Prediction Details

Protein: sym-2
Organism: Caenorhabditis elegans
Length: 618 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sym-2.

Description E-value Query
Range
Subject
Range
gi|73974158 - gi|73974158|ref|XP_848864.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
334.0 [0..90] [618..13]

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Predicted Domain #1
Region A:
Residues: [1-87]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRQTSHPEQ RLLLIRVSDG NYDENTKLVV TSFYPRRQED ANNNSTSPSS ASSSGSEIST  60
   61 RLVNITPEDV VKFFDEHPTS SYIFTKG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [88-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEPIRHVLIP LFARNELCVP HPLHHYYDIK HLYYGNQEED GMEQEEIEDD VAIARAILDM  60
   61 DDELLEKTHQ FVNIEYQPAP ILEDQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.221849
Match: 1fjeB
Description: Nucleolin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.30587477666777 bayes_pls_golite062009
nucleic acid binding 1.2660519582186 bayes_pls_golite062009
protein binding 0.88951142240317 bayes_pls_golite062009
RNA binding 0.498012521772139 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [174-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGADGDNVVC RARGLPWQAS DHHVAQFFAG LDIVPGGIAL CLSSEGRRNG EVLVQFSSQE  60
   61 SRDLALKRHR NFLLSRYIEV YKAGLDEFMH VATGSSTEAM EFVSANAIIV RMRGLPYDCT 120
  121 DAQIRTFFEP LKLTDKILFI TRTDGRPTGD AFVQFETEED AQQGLLKHRQ VIGQRYIELF 180
  181 KSTAAEVQQV VKRCNLI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.30103
Match: 1pgzA
Description: Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.30587477666777 bayes_pls_golite062009
nucleic acid binding 1.2660519582186 bayes_pls_golite062009
protein binding 0.88951142240317 bayes_pls_golite062009
RNA binding 0.498012521772139 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [371-511]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSPAVANAV EAPEEKKKDC VRLRGLPYEA TVQHIVTFLG DFATMVKFQG VHMVYNNQGH  60
   61 PSGEAFIQMI NEQAASACAA GVHNNFMSVG KKKRYIEVFQ ASAEELNLHH LVGQQHQVPP 120
  121 PAPLGFMGQL PPQAPQPQQF W

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.221849
Match: 2adbA
Description: Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [512-618]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSYPSPPISP IVPGQVTQLI IYGIHMSIGV PELVANFTTP EHTVDNVLFT RWPTHLCPGE  60
   61 AILTLRNRGA PPPQTSPLSQ ISQLSAPNFA AYSHHPQNFP LQPILME

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 1u6fA
Description: NMR solution structure of TcUBP1, a single RBD-unit from Trypanosoma cruzi
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.30587477666777 bayes_pls_golite062009
nucleic acid binding 1.2660519582186 bayes_pls_golite062009
protein binding 0.88951142240317 bayes_pls_golite062009
RNA binding 0.498012521772139 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle